Search Results - "Peyralans, Jérôme"
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Mechanosensitive Self-Replication Driven by Self-Organization
Published in Science (American Association for the Advancement of Science) (19-03-2010)“…Self-replicating molecules are likely to have played an important role in the origin of life, and a small number of fully synthetic self-replicators have…”
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Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates
Published in Applied microbiology and biotechnology (01-11-2008)“…Saturation mutagenesis constitutes a powerful method in the directed evolution of enzymes. Traditional protocols of whole plasmid amplification such as…”
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Uncovering the Selection Criteria for the Emergence of Multi-Building-Block Replicators from Dynamic Combinatorial Libraries
Published in Journal of the American Chemical Society (11-12-2013)“…A family of self-replicating macrocycles was developed using dynamic combinatorial chemistry. Replication is driven by self-assembly of the replicators into…”
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Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein
Published in Chemical communications (Cambridge, England) (04-11-2006)“…The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal-ligand centers anchored to proteins has…”
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Expanding the Substrate Scope of Enzymes: Combining Mutations Obtained by CASTing
Published in Chemistry : a European journal (07-08-2006)“…In a previous paper, the combinatorial active‐site saturation test (CAST) was introduced as an effective strategy for the directed evolution of enzymes toward…”
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Directed evolution of enantioselective hybrid catalysts: a novel concept in asymmetric catalysis
Published in Tetrahedron (09-07-2007)“…The concept of directed evolution of enantioselective hybrid catalysts was proposed in 2001/2002 and implemented experimentally for the first time in a…”
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A general synthesis of five, six and seven-membered silasultones via dehydrative cyclisation
Published in Tetrahedron (25-07-2005)“…Five, six and seven-membered silasultones can be conveniently prepared in good yield by dehydrative cyclisation of siloxane disulphonic acids. The siloxanes…”
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Recent highlights in systems chemistry
Published in Current opinion in chemical biology (01-12-2009)“…Systems chemistry deals with complex systems which exhibit properties that emerge only through the collective behavior of its components. Selected examples of…”
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