Search Results - "Petzold, Georg"

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN by Sievers, Quinlan L, Petzold, Georg, Bunker, Richard D, Renneville, Aline, Słabicki, Mikołaj, Liddicoat, Brian J, Abdulrahman, Wassim, Mikkelsen, Tarjei, Ebert, Benjamin L, Thomä, Nicolas H

“…The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros…”
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Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of…”
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biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes by Weissmann, Florian, Petzold, Georg, VanderLinden, Ryan, Veld, Pim J. Huis in ’t, Brown, Nicholas G., Lampert, Fabienne, Westermann, Stefan, Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael

“…Analyses of protein complexes are facilitated by methods that enable the generation of recombinant complexes via coexpression of their subunits from multigene…”
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Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly by Brown, Nicholas G., Watson, Edmond R., Weissmann, Florian, Jarvis, Marc A., VanderLinden, Ryan, Grace, Christy R.R., Frye, Jeremiah J., Qiao, Renping, Dube, Prakash, Petzold, Georg, Cho, Shein Ei, Alsharif, Omar, Bao, Ju, Davidson, Iain F., Zheng, Jie J., Nourse, Amanda, Kurinov, Igor, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Polyubiquitination by E2 and E3 enzymes is a predominant mechanism regulating protein function. Some RING E3s, including anaphase-promoting complex/cyclosome…”
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SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs by van der Lelij, Petra, Stocsits, Roman R, Ladurner, Rene, Petzold, Georg, Kreidl, Emanuel, Koch, Birgit, Schmitz, Julia, Neumann, Beate, Ellenberg, Jan, Peters, Jan-Michael

“…Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular…”
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Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Structural basis for the molecular evolution of SRP-GTPase activation by protein by Bange, Gert, Kümmerer, Nico, Grudnik, Przemyslaw, Lindner, Robert, Petzold, Georg, Kressler, Dieter, Hurt, Ed, Wild, Klemens, Sinning, Irmgard

“…SRP-type GTPases deviate from other GTPases in that they are not activated by GTPase-activating proteins (GAPs). New studies show that the MinD-type protein…”
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Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1 by Stark, Holger, Peters, Jan-Michael, Buschhorn, Bettina A, Petzold, Georg, Galova, Marta, Dube, Prakash, Kraft, Claudine, Herzog, Franz

“…The anaphase-promoting complex/cyclosome (APC/C) is key to cell cycle regulation and is an E3 ubiquitin ligase. The overall shape of the substrate-free complex…”
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crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP by Bange, Gert, Petzold, Georg, Wild, Klemens, Parlitz, Richard O, Sinning, Irmgard

“…Flagella are well characterized as the organelles of locomotion and allow bacteria to react to environmental changes. The assembly of flagella is a multistep…”
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Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown by Frye, Jeremiah J, Brown, Nicholas G, Petzold, Georg, Watson, Edmond R, Grace, Christy R R, Nourse, Amanda, Jarvis, Marc A, Kriwacki, Richard W, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A

“…APC/C is an E3 ligase complex of ~1.5 MDa that regulates cell division. APC/C CDH1 is inhibited during interphase by EMI1. Now, NMR spectroscopy, electron…”
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APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex by Uzunova, Kristina, Dye, Billy T, Schutz, Hannelore, Ladurner, Rene, Petzold, Georg, Toyoda, Yusuke, Jarvis, Marc A, Brown, Nicholas G, Poser, Ina, Novatchkova, Maria, Mechtler, Karl, Hyman, Anthony A, Stark, Holger, Schulman, Brenda A, Peters, Jan-Michael

“…Activation of the anaphase-promoting complex/cyclosome (APC/C) depends on disassembly of the mitotic checkpoint complex (MCC), which has been proposed to…”
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Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase by Petzold, Georg, Fischer, Eric S, Thomä, Nicolas H

“…Thalidomide and its derivatives, lenalidomide and pomalidomide, are immune modulatory drugs (IMiDs) used in the treatment of haematologic malignancies. IMiDs…”
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K by Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard D., Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, Fröhling, Stefan, Golub, Todd R., Fischer, Eric S., Thomä, Nicolas H., Ebert, Benjamin L.

“…Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation 1 . Unlike traditional…”
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Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome by Cavadini, Simone, Fischer, Eric S., Bunker, Richard D., Potenza, Alessandro, Lingaraju, Gondichatnahalli M., Goldie, Kenneth N., Mohamed, Weaam I., Faty, Mahamadou, Petzold, Georg, Beckwith, Rohan E. J., Tichkule, Ritesh B., Hassiepen, Ulrich, Abdulrahman, Wassim, Pantelic, Radosav S., Matsumoto, Syota, Sugasawa, Kaoru, Stahlberg, Henning, Thomä, Nicolas H.

“…The cullin–RING ubiquitin E3 ligase (CRL) family comprises over 200 members in humans. The COP9 signalosome complex (CSN) regulates CRLs by removing their…”
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Design principles for cyclin K molecular glue degraders by Kozicka, Zuzanna, Suchyta, Dakota J., Focht, Vivian, Kempf, Georg, Petzold, Georg, Jentzsch, Marius, Zou, Charles, Di Genua, Cristina, Donovan, Katherine A., Coomar, Seemon, Cigler, Marko, Mayor-Ruiz, Cristina, Schmid-Burgk, Jonathan L., Häussinger, Daniel, Winter, Georg E., Fischer, Eric S., Słabicki, Mikołaj, Gillingham, Dennis, Ebert, Benjamin L., Thomä, Nicolas H.

“…Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse…”
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You can glue it too by Walczak, Michal J, Petzold, Georg, Thomä, Nicolas H

“…Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent…”
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Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C by Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Weissmann, Florian, Ordureau, Alban, Wu, Kuen-Phon, Zhang, Wei, Yu, Shanshan, Mercredi, Peter Y., Harrison, Joseph S., Davidson, Iain F., Qiao, Renping, Lu, Ying, Dube, Prakash, Brunner, Michael R., Grace, Christy R.R., Miller, Darcie J., Haselbach, David, Jarvis, Marc A., Yamaguchi, Masaya, Yanishevski, David, Petzold, Georg, Sidhu, Sachdev S., Kuhlman, Brian, Kirschner, Marc W., Harper, J. Wade, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin…”
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Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase by Petzold, Georg, Fischer, Eric S., Thomä, Nicolas H.

“…Thalidomide and its derivative lenalidomide bind the CRL4 CRBN E3 ubiquitin ligase and target protein substrates for degradation; structural and functional…”
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Structural basis of lenalidomide-induced CK1[alpha] degradation by the CRL4^sup CRBN^ ubiquitin ligase by Petzold, Georg, Fischer, Eric S, Thomä, Nicolas H

“…Thalidomide and its derivatives, lenalidomide and pomalidomide, are immune modulatory drugs (IMiDs) used in the treatment of haematologic malignancies1,2…”
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Structural basis of lenalidomide-induced CK1α degradation by the [CRL4.sup.CRBN] ubiquitin ligase by Petzold, Georg, Fischer, Erie S, Thoma, Nicolas H

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