Search Results - "Petzold, Christopher J"
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Viscous control of cellular respiration by membrane lipid composition
Published in Science (American Association for the Advancement of Science) (07-12-2018)“…Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific…”
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Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production
Published in Metabolic engineering (01-09-2013)“…Limonene is a valuable monoterpene used in the production of several commodity chemicals and medicinal compounds. Among them, perillyl alcohol (POH) is a…”
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Synthetic protein scaffolds provide modular control over metabolic flux
Published in Nature biotechnology (01-08-2009)“…Engineered metabolic pathways are usually devoid of the regulatory mechanisms characteristic of natural metabolism. Using pathways not normally found in E…”
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Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer
Published in Nature communications (20-03-2018)“…Flowers of the hop plant provide both bitterness and “hoppy” flavor to beer. Hops are, however, both a water and energy intensive crop and vary considerably in…”
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Local and global structural drivers for the photoactivation of the orange carotenoid protein
Published in Proceedings of the National Academy of Sciences - PNAS (13-10-2015)“…Photoprotective mechanisms are of fundamental importance for the survival of photosynthetic organisms. In cyanobacteria, the orange carotenoid protein (OCP),…”
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Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale
Published in Nature communications (23-10-2020)“…High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-offs between carbon use for growth and production. To achieve…”
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Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2019)“…The rice immune receptor XA21 is activated by the sulfated microbial peptide required for activation of XA21-mediated immunity X (RaxX) produced by Xanthomonas…”
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Enhancing fatty acid production by the expression of the regulatory transcription factor FadR
Published in Metabolic engineering (01-11-2012)“…Fatty acids are important precursors to biofuels. The Escherichia coli FadR is a transcription factor that regulates several processes in fatty acid…”
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Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand-dependent activation of defense responses
Published in PLoS pathogens (01-03-2015)“…Plant plasma membrane localized pattern recognition receptors (PRRs) detect extracellular pathogen-associated molecules. PRRs such as Arabidopsis EFR and rice…”
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Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli
Published in Metabolic engineering (01-05-2018)“…Isopentenyl pyrophosphate (IPP) toxicity presents a challenge in engineered microbial systems since its formation is unavoidable in terpene biosynthesis. In…”
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Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol
Published in Microbial cell factories (03-12-2008)“…Increasing energy costs and environmental concerns have motivated engineering microbes for the production of "second generation" biofuels that have better…”
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Modular Engineering of l-Tyrosine Production in Escherichia coli
Published in Applied and Environmental Microbiology (01-01-2012)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli
Published in Scientific reports (08-06-2015)“…Branched five carbon (C 5 ) alcohols are attractive targets for microbial production due to their desirable fuel properties and importance as platform…”
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Lessons from Two Design–Build–Test–Learn Cycles of Dodecanol Production in Escherichia coli Aided by Machine Learning
Published in ACS synthetic biology (21-06-2019)“…The Design–Build–Test–Learn (DBTL) cycle, facilitated by exponentially improving capabilities in synthetic biology, is an increasingly adopted metabolic…”
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Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering
Published in Metabolic engineering (01-03-2015)“…Targeted proteomics is a convenient method determining enzyme expression levels, but a quantitative analysis of these proteomic data has not been fully…”
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Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization
Published in The Plant cell (01-09-2019)“…The order of enzymatic activity across Golgi cisternae is essential for complex molecule biosynthesis. However, an inability to separate Golgi cisternae has…”
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Heterohexamers Formed by CcmK3 and CcmK4 Increase the Complexity of Beta Carboxysome Shells
Published in Plant physiology (Bethesda) (01-01-2019)“…Bacterial microcompartments (BMCs) encapsulate enzymes within a selectively permeable, proteinaceous shell. Carboxysomes are BMCs containing…”
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Programming mRNA decay to modulate synthetic circuit resource allocation
Published in Nature communications (26-04-2017)“…Synthetic circuits embedded in host cells compete with cellular processes for limited intracellular resources. Here we show how funnelling of cellular…”
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An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors
Published in Molecular plant (01-05-2014)“…The rice XA21 immune receptor kinase and the structurally related XA3 receptor confer immunity to Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of…”
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Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit
Published in Nature communications (14-03-2024)“…Filamentous fungi are critical in the transition to a more sustainable food system. While genetic modification of these organisms has promise for enhancing the…”
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