Complex analysis of prognostic factors in chronic lymphocytic leukemia

Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. The mutation status of the Ig...

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Bibliographic Details
Published in:	Orvosi hetilap Vol. 148; no. 16; p. 737
Main Authors:	Kajtár, Béla, Jáksó, Pál, Kereskai, László, Lacza, Agnes, Méhes, Gábor, Bodnár, Mária Anna, Dombi, J Péter, Gasztonyi, Zoltán, Egyed, Miklós, Iványi, János László, Kovács, Gábor, Marton, Eva, Palaczki, Aranka, Petz, Sándor, Tóth, Péter, Sziládi, Erzsébet, Losonczy, Hajna, Pajor, László
Format:	Journal Article
Language:	Hungarian
Published:	Hungary 22-04-2007
Subjects:	ADP-ribosyl Cyclase 1 - metabolism Aged Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 17 DNA, Neoplasm - analysis Female Flow Cytometry Gene Deletion Gene Rearrangement Genes, Immunoglobulin Heavy Chain - genetics Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Male Middle Aged Mutation Predictive Value of Tests Prognosis Sequence Analysis, DNA Survival Analysis Trisomy ZAP-70 Protein-Tyrosine Kinase - metabolism
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Summary:	Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. The mutation status of the IgH gene was evaluated in 160 cases. In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
ISSN:	0030-6002