Search Results - "Petullo, David"

An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes by SOARS, Matthew G, PETULLO, David M, ECKSTEIN, James A, KASPER, Steve C, WRIGHTON, Steven A

“…Uridine diphosphate glucuronosyltransferases (UGTs) catalyze the glucuronidation of a wide range of xenobiotics and endogenous substrates. However, there is a…”
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Application of hypothetical strategies in acute pain by Zhong, Jinglin, Petullo, David

“…Since the publication of ICH E9 (R1), “Addendum to statistical principles for clinical trials: on choosing appropriate estimands and defining sensitivity…”
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Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome by Sauer, John-Michael, Long, Amanda J, Ring, Barbara, Gillespie, Jennifer S, Sanburn, Nathan P, DeSante, Karl A, Petullo, David, VandenBranden, Mark R, Jensen, Charles B, Wrighton, Steven A, Smith, Brian P, Read, Holly A, Witcher, Jennifer W

“…In the studies reported here, the ability of atomoxetine hydrochloride (Strattera) to inhibit or induce the metabolic capabilities of selected human isoforms…”
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THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES by MOHUTSKY, Michael A, PETULLO, David M, WRIGHTON, Steven A

“…The gold standard for estimating the ability of a new chemical entity to induce the human cytochromes P450 (P450s) is to determine the increase in catalytic…”
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Clinical pharmacology considerations for the approval of belimumab for the treatment of adult patients with active lupus nephritis: A regulatory perspective by Liu, Tao, Neuner, Rosemarie, Thompson, Aliza, Pottackal, Ginto, Petullo, David, Liu, Jiang, Nikolov, Nikolay, Sahajwalla, Chandrahas, Doddapaneni, Suresh, Chen, Jianmeng

“…On 16 December 2020, FDA approved Benlysta® (belimumab) for both the intravenous (IV) and subcutaneous (SC) administration routes for the treatment of adult…”
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A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro by Fayer, Jessica L, Petullo, David M, Ring, Barbara J, Wrighton, Steven A, Ruterbories, Kenneth J

“…Introduction: In order to examine CYP3A-mediated metabolism in vitro, a unique analytical assay was developed to detect the formation of 6β-hydroxytestosterone…”
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LOCALIZATION OF OXYTETRACYCLINE IN CHLAMYDOMONAS REINHARDTII (CHLOROPHYCEAE) by Garcia, Roberta J, Kane, Andrew S, Petullo, David, Reimschuessel, Renate

“…Oxytetracycline (OTC) is an important antimicrobial used in aquaculture. However, residues of OTC have been isolated from nontarget aquatic organisms,…”
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LOCALIZATION OF OXYTETRACYCLINE IN CHLAMYDOMONAS REINHARDTII (CHLOROPHYCEAE)1 by Garcia, Roberta J., Kane, Andrew S., Petullo, David, Reimschuessel, Renate

“…Oxytetracycline (OTC) is an important antimicrobial used in aquaculture. However, residues of OTC have been isolated from nontarget aquatic organisms,…”
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Model development and behavioral assessment of focal cerebral ischemia in rats by Petullo, David, Masonic, Kelly, Lincoln, Clint, Wibberley, Lizbeth, Teliska, Maggie, Yao, Da-Lin

“…Stroke in humans is usually focal and occurs in the Middle Cerebral Artery (MCA) distribution. There are several rat models that mimic strokes clinically seen…”
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Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats by Yao, Da-Lin, Masonic, Kelly, Petullo, David, Ling Li, Yu, Lincoln, Clint, Wibberley, Lizbeth, Alderson, Ralph F, Antonaccio, Michael

“…Fibroblast growth factor-13 (FGF-13), novel member of FGF family has recently been molecularly cloned as a result of high throughput sequencing of a ovarian…”
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