Search Results - "Petukhova, Galina"
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Genetic recombination is directed away from functional genomic elements in mice
Published in Nature (London) (31-05-2012)“…Comparison of Prdm9 −/− and wild-type mice reveals a role for the PRDM9 protein in directing the recombination machinery away from important genomic regions…”
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The evolutionary turnover of recombination hot spots contributes to speciation in mice
Published in Genes & development (01-02-2016)“…Meiotic recombination is required for the segregation of homologous chromosomes and is essential for fertility. In most mammals, the DNA double-strand breaks…”
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Recombination initiation maps of individual human genomes
Published in Science (American Association for the Advancement of Science) (14-11-2014)“…DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and generate crossovers, the reciprocal exchanges of genetic material…”
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Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice
Published in Genes & development (01-06-2024)Get full text
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5
Extensive sex differences at the initiation of genetic recombination
Published in Nature (London) (01-09-2018)“…Meiotic recombination differs between males and females; however, when and how these differences are established is unknown. Here we identify extensive sex…”
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Genome-wide analysis reveals novel molecular features of mouse recombination hotspots
Published in Nature (London) (21-04-2011)“…Hot spots for meiotic recombination To initiate the recombination process that guides accurate chromosome segregation during meiosis, programmed double-strand…”
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Protein and Peptide Substances in the Treatment of Respiratory Syncytial Infection: Current State
Published in Molecules (Basel, Switzerland) (31-03-2022)“…Respiratory syncytial virus infection (RSVI) is an acute medical and social problem in many countries globally. Infection is most dangerous for infants under…”
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Interrogating the Functions of PRDM9 Domains in Meiosis
Published in Genetics (Austin) (01-06-2018)“…Homologous recombination is required for proper segregation of homologous chromosomes during meiosis. It occurs predominantly at recombination hotspots that…”
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Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA
Published in Genome research (01-05-2012)“…Meiotic DNA double-stranded breaks (DSBs) initiate genetic recombination in discrete areas of the genome called recombination hotspots. DSBs can be directly…”
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Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
Published in Molecules (Basel, Switzerland) (10-12-2021)“…Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for…”
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Heavy Metal Migration in Soil-Plant System in Conditions of Urban Environmental Pollution
Published in Air, soil and water research (01-06-2023)“…This study is devoted to heavy metal soil migration to coltsfoot in urban pollution of Tyumen city. Soil and plant samples were collected in the summer of 2017…”
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Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2
Published in Natural product research (18-06-2023)“…A set of 12 abietane diterpene derivatives have been synthesised by the Ugi-four component reaction (Ugi-4CR) and tested for cytotoxicity and activity against…”
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Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
Published in BMC biology (28-04-2021)“…Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of…”
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Biochemical Responses of Medicinal Plant Tussilago farfara L. to Elevated Heavy Metal Concentrations in Soils of Urban Areas
Published in Toxics (Basel) (17-07-2021)“…This study was conducted in Tyumen (Russian Federation) to establish the effects of heavy metals’ (Cu, Zn, Fe, Mn, Pb, and Cd) accumulation in soil and…”
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Analysis of Meiotic Double-Strand Break Initiation in Mammals
Published in Methods in enzymology (2018)“…The repair of programmed DNA double-strand breaks (DSBs) physically tethers homologous chromosomes in meiosis to allow for accurate segregation through meiotic…”
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Discovery of N-Containing (-)-Borneol Esters as Respiratory Syncytial Virus Fusion Inhibitors
Published in Pharmaceuticals (Basel, Switzerland) (01-11-2022)“…Respiratory syncytial virus (RSV) causes acute respiratory infections, thus, posing a serious threat to the health of infants, children, and elderly people. In…”
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Silver ion-assisted substitutive fluorination of chlorofullerenes
Published in Journal of fluorine chemistry (01-09-2020)“…[Display omitted] •Silver monofluoride fluorinates chlorofullerenes yielding novel fullerene halides.•Cl/F exchange pathway preserves the initial addition…”
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Synthesis and evaluation of diterpenic Mannich bases as antiviral agents against influenza A and SARS-CoV-2
Published in Phytochemistry letters (01-10-2022)“…A chemical library was constructed based on the resin acids (abietic, dehydroabietic, and 12-formylabietic) and its diene adducts (maleopimaric and…”
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Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase
Published in Genes & development (15-07-2007)“…The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds…”
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Erratum: The evolutionary turnover of recombination hot spots contributes to speciation in mice
Published in Genes & development (01-04-2016)“…Due to a technical error in processing the figures in the above-mentioned article, Figures 3, A and B; 4B; 5B; and 6, A and C contained errors or missing…”
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