Search Results - "Petts, Gemma"

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure by Triantafyllou, Evangelos, Pop, Oltin T, Possamai, Lucia A, Wilhelm, Annika, Liaskou, Evaggelia, Singanayagam, Arjuna, Bernsmeier, Christine, Khamri, Wafa, Petts, Gemma, Dargue, Rebecca, Davies, Scott P, Tickle, Joseph, Yuksel, Muhammed, Patel, Vishal C, Abeles, Robin D, Stamataki, Zania, Curbishley, Stuart M, Ma, Yun, Wilson, Ian D, Coen, Muireann, Woollard, Kevin J, Quaglia, Alberto, Wendon, Julia, Thursz, Mark R, Adams, David H, Weston, Chris J, Antoniades, Charalambos G

“…Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic…”
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De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma by Abbassi-Ghadi, Nima, Antonowicz, Stefan S, McKenzie, James S, Kumar, Sacheen, Huang, Juzheng, Jones, Emrys A, Strittmatter, Nicole, Petts, Gemma, Kudo, Hiromi, Court, Stephen, Hoare, Jonathan M, Veselkov, Kirill, Goldin, Robert, Takáts, Zoltán, Hanna, George B

“…The incidence of esophageal adenocarcinoma is rising, survival remains poor, and new tools to improve early diagnosis and precise treatment are needed. Cancer…”
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Enzyme replacement therapy and hematopoietic stem cell transplant: a new paradigm of treatment in Wolman disease by Potter, Jane E, Petts, Gemma, Ghosh, Arunabha, White, Fiona J, Kinsella, Jane L, Hughes, Stephen, Roberts, Jane, Hodgkinson, Adam, Brammeier, Kathryn, Church, Heather, Merrigan, Christine, Hughes, Joanne, Evans, Pamela, Campbell, Helen, Bonney, Denise, Newman, William G, Bigger, Brian W, Broomfield, Alexander, Jones, Simon A, Wynn, Robert F

“…Wolman disease is a rare, lysosomal storage disorder in which biallelic variants in the LIPA gene result in reduced or complete lack of lysosomal acid lipase…”
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Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells by O'Brien, Eleanor, Tse, Carmen, Tracy, Ian, Reddin, Ian, Selfe, Joanna, Gibson, Jane, Tapper, William, Pengelly, Reuben J, Gao, Jinhui, Aladowicz, Ewa, Petts, Gemma, Thway, Khin, Popov, Sergey, Kelsey, Anna, Underwood, Timothy J, Shipley, Janet, Walters, Zoë S

“…Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic…”
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Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis by Alazawi, William, Heath, Helen, Waters, Jennifer A., Woodfin, Abigail, O'Brien, Alastair J., Scarzello, Anthony J., Ma, Bin, Lopez-Otalora, Yolanda, Jacobs, Michael, Petts, Gemma, Goldin, Robert D., Nourshargh, Sussan, Gamero, Ana M., Foster, Graham R.

“…Deregulated Toll-like receptor (TLR)-triggered inflammatory responses that depend on NF-κB are detrimental to the host via excessive production of…”
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Achieving uterine auto-transplantation in a sheep model using iliac vessel anastomosis: a short-term viability study by Saso, Srdjan, Petts, Gemma, Thum, Meen-Yau, Corless, David, Boyd, Michael, Noakes, David, Del Priore, Giuseppe, Ghaem-Maghami, Sadaf, Smith, James Richard

“…To investigate, develop and evaluate anatomical, surgical and anastomotic aspects necessary for a successful uterine transplant in a large-animal model. Sheep…”
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Uterine allotransplantation in a rabbit model using aorto-caval anastomosis: a long-term viability study by Saso, Srdjan, Petts, Gemma, Chatterjee, Jayanta, Thum, Meen-Yau, David, Anna L, Corless, David, Boyd, Michael, Noakes, David, Lindsay, Iain, Del Priore, Giuseppe, Ghaem-Maghami, Sadaf, Smith, J Richard

“…Abstract Objective Uterine transplantation (UTx) has been proposed as a treatment option for women diagnosed with absolute uterine factor infertility…”
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Achieving an early pregnancy following allogeneic uterine transplantation in a rabbit model by Saso, Srdjan, Petts, Gemma, David, Anna L, Thum, Meen-Yau, Chatterjee, Jayanta, Vicente, Jose S, Marco-Jimenez, Francisco, Corless, David, Boyd, Michael, Noakes, David, Lindsay, Iain, Del Priore, Giuseppe, Ghaem-Maghami, Sadaf, Smith, J. Richard

“…Abstract Objective Uterine transplantation (UTx) has been proposed as a treatment option for women diagnosed with absolute uterine factor infertility (AUFI)…”
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Rhabdomyosarcoma and undifferentiated round cell tumours of soft tissue in children, adolescents and young adults by Keir, Heather, Cheesman, Edmund, Staunton, Michael, Petts, Gemma, Kelsey, Anna

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Spindle cell and fibrohistiocytic soft tissue tumours of infancy and childhood by Petts, Gemma, Keir, Heather, Staunton, Michael, Kelsey, Anna, Cheesman, Edmund

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The diagnostic and prognostic significance of liver histology in alcoholic hepatitis by Forrest, Ewan, Petts, Gemma, Austin, Andrew, Lloyd, Kirsty, Wright, Mark, Vergis, Nikhil, Atkinson, Stephen, Masson, Steven, Patch, David, Quaglia, Alberto, Thursz, Mark, Goldin, Robert

“…Summary Background Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. Aim To assess the…”
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Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death by Ommer, Johannes, Selfe, Joanna L, Wachtel, Marco, O'Brien, Eleanor M, Laubscher, Dominik, Roemmele, Michaela, Kasper, Stephanie, Delattre, Olivier, Surdez, Didier, Petts, Gemma, Kelsey, Anna, Shipley, Janet, Schäfer, Beat W

“…The clinically aggressive alveolar rhabdomyosarcoma (RMS) subtype is characterized by expression of the oncogenic fusion protein PAX3-FOXO1, which is critical…”
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Prisoners as Living Kidney Donors: Unlocking the Potential by McLachlan, Charlotte, Petts, Gemma

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Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase by Vergis, Nikhil, Khamri, Wafa, Beale, Kylie, Sadiq, Fouzia, Aletrari, Mina O, Moore, Celia, Atkinson, Stephen R, Bernsmeier, Christine, Possamai, Lucia A, Petts, Gemma, Ryan, Jennifer M, Abeles, Robin D, James, Sarah, Foxton, Matthew, Hogan, Brian, Foster, Graham R, O'Brien, Alastair J, Ma, Yun, Shawcross, Debbie L, Wendon, Julia A, Antoniades, Charalambos G, Thursz, Mark R

“…In order to explain the increased susceptibility to serious infection in alcoholic hepatitis, we evaluated monocyte phagocytosis, aberrations of associated…”
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Biallelic TMEM260 variants cause truncus arteriosus, with or without renal defects by Pagnamenta, Alistair T., Jackson, Adam, Perveen, Rahat, Beaman, Glenda, Petts, Gemma, Gupta, Asheeta, Hyder, Zerin, Chung, Brian Hon‐Yin, Kan, Anita Sik‐Yau, Cheung, Ka Wang, Kerstjens‐Frederikse, Wilhelmina S., Abbott, Kristin M., Elpeleg, Orly, Taylor, Jenny C., Banka, Siddharth, Ta‐Shma, Asaf

“…Only two families have been reported with biallelic TMEM260 variants segregating with structural heart defects and renal anomalies syndrome (SHDRA). With a…”
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Emergency department management of undifferentiated abdominal pain with hyoscine butylbromide and paracetamol: a randomised control trial by Remington-Hobbs, Jennifer, Petts, Gemma, Harris, Tim

“…To compare the effectiveness of paracetamol, hyoscine butylbromide and the combination of paracetamol plus hyoscine butylbromide (paracetamol + hyoscine…”
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Fatty liver disease by Petts, Gemma, Lloyd, Kirsty, Goldin, Robert

“…Abstract It is now widely accepted that fatty liver disease is one of the commonest causes of cirrhosis and liver cell cancer (even in the absence of…”
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Pancreatic adenocarcinoma presenting with sudden onset bilateral deafness secondary to metastatic leptomeningeal infiltration by Blows, Samuel Joseph, Morgan, Richard, Dhariwal, Umeet, Petts, Gemma, Roncaroli, Frederico

“…Deafness is a very common problem in older persons. We present a case of metastatic adenocarcinoma of the pancreas with deafness being the patient's only…”
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Histopathological and immunohistochemical features of early hydatidiform mole in relation to subsequent development of persistent gestational trophoblastic disease by Petts, Gemma, Fisher, Rosemary A, Short, Dee, Lindsay, Ian, Seckl, Michael J, Sebire, Neil J

“…To examine histomorphological and immunohistochemical findings in hydatidiform moles to determine whether any features can reliably predict clinical behavior…”
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The role of the coagulation cascade in liver injury by Petts, Gemma Susan

“…Liver disease affects approximately 600,000 people in England and Wales and is the third biggest cause of premature death. Acute and chronic liver injury occur…”
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