Search Results - "Pettipher, R."

The roles of the prostaglandin D 2 receptors DP 1 and CRTH2 in promoting allergic responses by Pettipher, R

“…Prostaglandin D 2 (PGD 2 ) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of allergic…”
Get full text

Anti‐eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis by Straumann, A., Hoesli, S., Bussmann, Ch, Stuck, M., Perkins, M., Collins, L. P., Payton, M., Pettipher, R., Hunter, M., Steiner, J., Simon, H.‐U.

“…Background Eosinophilic esophagitis (EoE) is a chronic, Th2‐type inflammatory disease. Chemoattractant receptor‐homologous molecule on Th2 cells (CRTH2) is a…”
Get full text

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459 by Pettipher, R., Hunter, M. G., Perkins, C. M., Collins, L. P., Lewis, T., Baillet, M., Steiner, J., Bell, J., Payton, M. A.

“…Background The CRTH2 antagonist OC000459 has previously been demonstrated to reduce airway inflammation and improve lung function in moderate persistent…”
Get full text

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma by Barnes, N., Pavord, I., Chuchalin, A., Bell, J., Hunter, M., Lewis, T., Parker, D., Payton, M., Collins, L. Pearce, Pettipher, R., Steiner, J., Perkins, C. M.

“…Summary Background CRTH2 is a G‐protein‐coupled receptor that mediates the activation of Th2 lymphocytes, eosinophils and basophils in response to…”
Get full text

The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial by Horak, F., Zieglmayer, P., Zieglmayer, R., Lemell, P., Collins, L. P., Hunter, M. G., Steiner, J., Lewis, T., Payton, M. A., Perkins, C. M., Pettipher, R.

“…Background CRTH2 mediates activation of Th2 cells, eosinophils and basophils in response to prostaglandin D2. The CRTH2 antagonist OC000459 has previously been…”
Get full text

The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses by Pettipher, R

“…Prostaglandin D2 (PGD2) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of allergic…”
Get full text

Interaction between prostaglandin D₂ and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells by Xue, L, Barrow, A, Pettipher, R

“…The mechanisms by which immunologically activated mast cells stimulate the production of proinflammatory cytokines by T helper type 2 (Th2) lymphocytes were…”
Get full text

CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue by Pérez-Novo, C A, Holtappels, G, Vinall, S L, Xue, L, Zhang, N, Bachert, C, Pettipher, R

“…Mast cells release mediators upon stimulation that contribute to the pathogenesis of chronic airway disease, including the recruitment and activation of Th2…”
Get full text

Systemic administration of the chemokine macrophage inflammatory protein 1α exacerbates inflammatory bowel disease in a mouse model by Pender, S L-F, Chance, V, Whiting, C V, Buckley, M, Edwards, M, Pettipher, R, MacDonald, T T

“…Introduction: Exacerbations of inflammatory bowel disease are thought to be related to concurrent infections. As infections are associated with elevated local…”
Get full text

CRTH2 mediates the activation of human Th2 cells in response to PGD₂ released from IgE/anti-IgE treated nasal polyp tissue by Pérez-Novo, C.A, Holtappels, G, Vinall, S.L, Xue, L, Zhang, N, Bachert, C, Pettipher, R

“…To cite this article: Pérez- Novo CA, Holtappels G, Vinall SL, Xue L, Zhang N, Bachert C, Pettipher R. CRTH2 mediates the activation of human Th2 cells in…”
Get full text

Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis by Griffiths, R J, Pettipher, E R, Koch, K, Farrell, C A, Breslow, R, Conklyn, M J, Smith, M A, Hackman, B C, Wimberly, D J, Milici, A J

“…Leukotriene B4 (LTB4) is a product of the 5-lipoxygenase pathway of arachidonic acid metabolism. LTB4 is a potent chemotactic factor for neutrophils and has…”
Get full text

Interleukin 1 Induces Leukocyte Infiltration and Cartilage Proteoglycan Degradation in the Synovial Joint by Pettipher, E. Roy, Higgs, Gerald A., Henderson, Brian

“…Interleukin 1 (IL-1) is a polypeptide released by activated macrophages and is thought to be a key mediator of host responses to infection and inflammation…”
Get full text

Arthritogenic actions of recombinant IL-1 and tumour necrosis factor α in the rabbit: evidence for synergistic interactions between cytokines in vivo by HENDERSON, B, PETTIPHER, E. R

“…Intra-articular injection of highly purified or recombinant interleukin 1 (IL-1) into the rabbit knee induces a transient synovitis with leucocytic…”
Get full text

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis by Gladue, R P, Carroll, L A, Milici, A J, Scampoli, D N, Stukenbrok, H A, Pettipher, E R, Salter, E D, Contillo, L, Showell, H J

“…Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple…”
Get full text

Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues:  Implications for a New Active Site Model of PDE4 by Kleinman, Edward F, Campbell, Erin, Giordano, Lisa A, Cohan, Victoria L, Jenkinson, Teresa H, Cheng, John B, Shirley, John T, Pettipher, E. Roy, Salter, Eben D, Hibbs, Tessa A, DiCapua, Frank M, Bordner, John

Get full text

The application of genetics to the discovery of better medicines by Pettipher, Roy, Cardon, Lon R

“…The availability of the human genome sequence and the increasing knowledge of functional polymorphisms will highlight new therapeutic approaches to treat…”
Get more information

2‐Amino‐4‐methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo by Faraci, W. Stephen, Nagel, Arthur A., Verdries, Kimberly A., Vincent, Lawrence A., Xu, Hong, Nichols, Lois E., Labasi, Jeffrey M., Salter, Eben D., Pettipher, E. Roy

“…1 The ability of 2‐amino‐4‐methylpyridine to inhibit the catalytic activity of the inducible NO synthase (NOS II) enzyme was characterized in vitro and in…”
Get full text

The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543 by Showell, H J, Conklyn, M J, Alpert, R, Hingorani, G P, Wright, K F, Smith, M A, Stam, E, Salter, E D, Scampoli, D N, Meltzer, S, Reiter, L A, Koch, K, Piscopio, A D, Cortina, S R, Lopez-Anaya, A, Pettipher, E R, Milici, A J, Griffiths, R J

“…CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor…”
Get more information

The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses by Pettipher, R

“…Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of allergic…”
Get full text

The roles of the prostaglandin D sub(2) receptors DP sub(1) and CRTH2 in promoting allergic responses by Pettipher, R

“…Prostaglandin D sub(2) (PGD sub(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of…”
Get full text