Search Results - "Pettigrew, Gavin"

T cell Allorecognition Pathways in Solid Organ Transplantation by Siu, Jacqueline H Y, Surendrakumar, Veena, Richards, James A, Pettigrew, Gavin J

“…Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells…”
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Kidney donation after circulatory death (DCD): state of the art by Summers, Dominic M, Watson, Christopher J E, Pettigrew, Gavin J, Johnson, Rachel J, Collett, David, Neuberger, James M, Bradley, J Andrew

“…The use of kidneys from controlled donation after circulatory death (DCD) donors has the potential to markedly increase kidney transplants performed. However,…”
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Defining Delayed Graft Function after Renal Transplantation: Simplest Is Best by Mallon, Dermot H, Summers, Dominic M, Bradley, J Andrew, Pettigrew, Gavin J

“…BACKGROUNDDelayed graft function (DGF) after renal transplantation can be diagnosed according to several different definitions, complicating comparison between…”
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Allorecognition Unveiled: Integrating Recent Breakthroughs Into the Current Paradigm by Charmetant, Xavier, Pettigrew, Gavin J., Thaunat, Olivier

“…In transplantation, genetic differences between donor and recipient trigger immune responses that cause graft rejection. Allorecognition, the process by which…”
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Survival advantage for patients accepting the offer of a circulatory death liver transplant by Taylor, Rhiannon, Allen, Elisa, Richards, James A., Goh, Mingzheng A., Neuberger, James, Collett, David, Pettigrew, Gavin J.

“…[Display omitted] •Outcomes for DCD are inferior to DBD liver transplantation in the UK experience.•There is a survival advantage in accepting a DCD offer…”
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Real-world Effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S Vaccines Against SARS-CoV-2 in Solid Organ and Islet Transplant Recipients by Callaghan, Chris J., Mumford, Lisa, Curtis, Rebecca M. K., Williams, Sarah V., Whitaker, Heather, Andrews, Nick, Lopez Bernal, Jamie, Ushiro-Lumb, Ines, Pettigrew, Gavin J., Thorburn, Douglas, Forsythe, John L. R., Ravanan, Rommel

“…The clinical effectiveness of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunosuppressed solid organ and islet…”
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A Systematic Review of Opt-out Versus Opt-in Consent on Deceased Organ Donation and Transplantation (2006–2016) by Ahmad, M. Usman, Hanna, Afif, Mohamed, Ahmed-Zayn, Schlindwein, Alex, Pley, Caitlin, Bahner, Ingrid, Mhaskar, Rahul, Pettigrew, Gavin J., Jarmi, Tambi

“…Background Significant numbers of patients in the USA and UK die while waiting for solid organ transplant. Only 1–2% of deaths are eligible as donors with a…”
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Preoperative Assessment of the Deceased-Donor Kidney: From Macroscopic Appearance to Molecular Biomarkers by Dare, Anna J, Pettigrew, Gavin J, Saeb-Parsy, Kourosh

“…Variation in deceased-donor kidney quality can significantly affect outcomes after kidney transplantation. Suboptimal organ selection for a given recipient can…”
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Passenger donor lymphocytes: To affinity and beyond by Manook, Miriam, Motallebzadeh, Reza, Pettigrew, Gavin J

“…Graft-versus-host recognition by passenger donor lymphocytes within organ transplants can trigger host alloantibody production (Charmetant .)…”
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Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation by Alsughayyir, Jawaher, Pettigrew, Gavin J, Motallebzadeh, Reza

“…Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs…”
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Allorecognition Pathways in Transplant Rejection and Tolerance by Ali, Jason M, Bolton, Eleanor M, Bradley, J Andrew, Pettigrew, Gavin J

“…With the advent of cellular therapies, it has become clear that the success of future therapies in prolonging allograft survival will require an intimate…”
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Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ by Dare, Anna J, Bolton, Eleanor A, Pettigrew, Gavin J, Bradley, J Andrew, Saeb-Parsy, Kourosh, Murphy, Michael P

“…Ischemia-reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension, sepsis and in surgical procedures…”
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The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model by Dare, Anna J., MBBCh, PhD, Logan, Angela, PhD, Prime, Tracy A., BSc, Rogatti, Sebastian, BSc, Goddard, Martin, MBBCh, FRCPath, Bolton, Eleanor M., PhD, Bradley, J. Andrew, MBBCh, PhD, FRCS, Pettigrew, Gavin J., MBBCh, MD, FRCS, Murphy, Michael P., PhD, Saeb-Parsy, Kourosh, MBBCh, PhD, FRCS

“…Background Free radical production and mitochondrial dysfunction during cardiac graft reperfusion is a major factor in post-transplant ischemia-reperfusion…”
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Kidney transplantation following uncontrolled donation after circulatory death by Summers, Dominic M., Pettigrew, Gavin J.

“…The identification and utilization of kidneys from uncontrolled donation after circulatory death (uDCD) donors for transplantation may increase transplantation…”
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Artificial Intelligence You Can Trust: What Matters Beyond Performance When Applying Artificial Intelligence to Renal Histopathology? by Ayorinde, John O O, Citterio, Federica, Landrò, Matteo, Peruzzo, Elia, Islam, Tuba, Tilley, Simon, Taylor, Geoffrey, Bardsley, Victoria, Liò, Pietro, Samoshkin, Alex, Pettigrew, Gavin J

“…Although still in its infancy, artificial intelligence (AI) analysis of kidney biopsy images is anticipated to become an integral aspect of renal…”
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Analysis of ischemia/reperfusion injury in time‐zero biopsies predicts liver allograft outcomes by Ali, Jason M., Davies, Susan E., Brais, Rebecca J., Randle, Lucy V., Klinck, John R., Allison, Michael E. D., Chen, Yining, Pasea, Laura, Harper, Simon F. J., Pettigrew, Gavin J.

“…Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long‐term graft survival, but it remains poorly understood. Here we…”
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Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural by Siu, Jacqueline H.Y., Motallebzadeh, Reza, Pettigrew, Gavin J.

“…Non-HLA antibody responses following solid organ transplantation have become increasingly emphasised, with several large clinical series suggesting that such…”
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CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection by Harper, Simon J. F., Ali, Jason M., Wlodek, Elizabeth, Negus, Marg C., Harper, Ines G., Chhabra, Manu, Qureshi, M. Saeed, Mallik, Mekhola, Bolton, Eleanor, Bradley, J. Andrew, Pettigrew, Gavin J.

“…Adaptive CD8 T-cell immunity is the principal arm of the cellular alloimmune response, but its development requires help. This can be provided by CD4 T cells…”
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The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation by Malik, Abdullah K., Tingle, Samuel J., Chung, Nicholas, Owen, Ruth, Mahendran, Balaji, Counter, Claire, Sinha, Sanjay, Muthasamy, Anand, Sutherland, Andrew, Casey, John, Drage, Martin, van Dellen, David, Callaghan, Chris J., Elker, Doruk, Manas, Derek M., Pettigrew, Gavin J., Wilson, Colin H., White, Steven A.

“…The time to arrest donors after circulatory death is unpredictable and can vary. This leads to variable periods of warm ischemic damage prior to pancreas…”
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Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant by Harper, Ines G., Ali, Jason M., Harper, Simon J.F., Wlodek, Elizabeth, Alsughayyir, Jawaher, Negus, Margaret C., Qureshi, M. Saeed, Motalleb-Zadeh, Reza, Saeb-Parsy, Kourosh, Bolton, Eleanor M., Bradley, J. Andrew, Clatworthy, Menna R., Conlon, Thomas M., Pettigrew, Gavin J.

“…Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the…”
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