Search Results - "Pettie, Deleah"

Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Crawford, Katharine H D, Dingens, Adam S, Eguia, Rachel, Wolf, Caitlin R, Wilcox, Naomi, Logue, Jennifer K, Shuey, Kiel, Casto, Amanda M, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, King, Neil P, Greninger, Alexander L, Chu, Helen Y, Bloom, Jesse D

“…Abstract Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak by Dingens, Adam S., Crawford, Katharine H. D., Adler, Amanda, Steele, Sarah L., Lacombe, Kirsten, Eguia, Rachel, Amanat, Fatima, Walls, Alexandra C., Wolf, Caitlin R., Murphy, Michael, Pettie, Deleah, Carter, Lauren, Qin, Xuan, King, Neil P., Veesler, David, Krammer, Florian, Dickerson, Jane A., Chu, Helen Y., Englund, Janet A., Bloom, Jesse D.

“…Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed…”
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Structure-based design of stabilized recombinant influenza neuraminidase tetramers by Ellis, Daniel, Lederhofer, Julia, Acton, Oliver J., Tsybovsky, Yaroslav, Kephart, Sally, Yap, Christina, Gillespie, Rebecca A., Creanga, Adrian, Olshefsky, Audrey, Stephens, Tyler, Pettie, Deleah, Murphy, Michael, Sydeman, Claire, Ahlrichs, Maggie, Chan, Sidney, Borst, Andrew J., Park, Young-Jun, Lee, Kelly K., Graham, Barney S., Veesler, David, King, Neil P., Kanekiyo, Masaru

“…Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently reemerged as a key target of antibody-mediated protective immunity. Here…”
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In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 by Phan, Isabelle Q., Subramanian, Sandhya, Kim, David, Murphy, Michael, Pettie, Deleah, Carter, Lauren, Anishchenko, Ivan, Barrett, Lynn K., Craig, Justin, Tillery, Logan, Shek, Roger, Harrington, Whitney E., Koelle, David M., Wald, Anna, Veesler, David, King, Neil, Boonyaratanakornkit, Jim, Isoherranen, Nina, Greninger, Alexander L., Jerome, Keith R., Chu, Helen, Staker, Bart, Stewart, Lance, Myler, Peter J., Van Voorhis, Wesley C.

“…Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19…”
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Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice by Grigoryan, Lilit, Lee, Audrey, Walls, Alexandra C., Lai, Lilin, Franco, Benjamin, Arunachalam, Prabhu S., Feng, Yupeng, Luo, Wei, Vanderheiden, Abigail, Floyd, Katharine, Wrenn, Samuel, Pettie, Deleah, Miranda, Marcos C., Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, Coffman, Robert L., Novack, David, Kleanthous, Harry, O’Hagan, Derek T., van der Most, Robbert, McLellan, Jason S., Suthar, Mehul, Veesler, David, King, Neil P., Pulendran, Bali

“…Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the…”
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Antigen spacing on protein nanoparticles influences antibody responses to vaccination by Ellis, Daniel, Dosey, Annie, Boyoglu-Barnum, Seyhan, Park, Young-Jun, Gillespie, Rebecca, Syeda, Hubza, Hutchinson, Geoffrey B., Tsybovsky, Yaroslav, Murphy, Michael, Pettie, Deleah, Matheson, Nick, Chan, Sidney, Ueda, George, Fallas, Jorge A., Carter, Lauren, Graham, Barney S., Veesler, David, Kanekiyo, Masaru, King, Neil P.

“…Immunogen design approaches aim to control the specificity and quality of antibody responses elicited by next-generation vaccines. Here, we use computational…”
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Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design by Ellis, Daniel, Brunette, Natalie, Crawford, Katharine H. D., Walls, Alexandra C., Pham, Minh N., Chen, Chengbo, Herpoldt, Karla-Luise, Fiala, Brooke, Murphy, Michael, Pettie, Deleah, Kraft, John C., Malone, Keara D., Navarro, Mary Jane, Ogohara, Cassandra, Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Ahlrichs, Maggie, Johnson, Max, Blackstone, Alyssa, Carter, Lauren, Starr, Tyler N., Greaney, Allison J., Lee, Kelly K., Veesler, David, Bloom, Jesse D., King, Neil P.

“…The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to…”
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Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination by Cagigi, Alberto, Yu, Meng, Österberg, Björn, Svensson, Julia, Falck-Jones, Sara, Vangeti, Sindhu, Åhlberg, Eric, Azizmohammadi, Lida, Warnqvist, Anna, Falck-Jones, Ryan, Gubisch, Pia C, Ödemis, Mert, Ghafoor, Farangies, Eisele, Mona, Lenart, Klara, Bell, Max, Johansson, Niclas, Albert, Jan, Sälde, Jörgen, Pettie, Deleah D, Murphy, Michael P, Carter, Lauren, King, Neil P, Ols, Sebastian, Normark, Johan, Ahlm, Clas, Forsell, Mattias N, Färnert, Anna, Loré, Karin, Smed-Sörensen, Anna

“…Understanding the presence and durability of antibodies against SARS-CoV-2 in the airways is required to provide insights into the ability of individuals to…”
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Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens by Miranda, Marcos C., Kepl, Elizabeth, Navarro, Mary Jane, Chen, Chengbo, Johnson, Max, Sprouse, Kaitlin R., Stewart, Cameron, Palser, Anne, Valdez, Adian, Pettie, Deleah, Sydeman, Claire, Ogohara, Cassandra, Kraft, John C., Pham, Minh, Murphy, Michael, Wrenn, Sam, Fiala, Brooke, Ravichandran, Rashmi, Ellis, Daniel, Carter, Lauren, Corti, Davide, Kellam, Paul, Lee, Kelly, Walls, Alexandra C., Veesler, David, King, Neil P.

“…We previously described a two-component protein nanoparticle vaccine platform that displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The…”
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Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges by Shetty, Shamitha, Alvarado, Pablo Cordero, Pettie, Deleah, Collier, Joel H

“…Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford…”
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Quadrivalent influenza nanoparticle vaccines induce broad protection by Boyoglu-Barnum, Seyhan, Ellis, Daniel, Gillespie, Rebecca A., Hutchinson, Geoffrey B., Park, Young-Jun, Moin, Syed M., Acton, Oliver J., Ravichandran, Rashmi, Murphy, Mike, Pettie, Deleah, Matheson, Nick, Carter, Lauren, Creanga, Adrian, Watson, Michael J., Kephart, Sally, Ataca, Sila, Vaile, John R., Ueda, George, Crank, Michelle C., Stewart, Lance, Lee, Kelly K., Guttman, Miklos, Baker, David, Mascola, John R., Veesler, David, Graham, Barney S., King, Neil P., Kanekiyo, Masaru

“…Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the…”
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Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 by Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Guerriero, Kathryn, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.

“…A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein…”
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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines by Walls, Alexandra C., Miranda, Marcos C., Schäfer, Alexandra, Pham, Minh N., Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shirreff, Lisa, Ferrell, Douglas E., Bowen, John, Brunette, Natalie, Kepl, Elizabeth, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Sprouse, Kaitlin R., Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, Leist, Sarah R., Martinez, David R., Clark, Matthew, Tisch, Roland, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., Corti, Davide, McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Smith, Kelly D., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph S., King, Neil P., Veesler, David

“…Understanding vaccine-elicited protection against SARS-CoV-2 variants and other sarbecoviruses is key for guiding public health policies. We show that a…”
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Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses by McLeod, Brandon, Mabrouk, Moustafa T, Miura, Kazutoyo, Ravichandran, Rashmi, Kephart, Sally, Hailemariam, Sophia, Pham, Thao P, Semesi, Anthony, Kucharska, Iga, Kundu, Prasun, Huang, Wei-Chiao, Johnson, Max, Blackstone, Alyssa, Pettie, Deleah, Murphy, Michael, Kraft, John C, Leaf, Elizabeth M, Jiao, Yang, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Ramjith, Jordache, King, C Richter, MacGill, Randall S, Wu, Yimin, Lee, Kelly K, Jore, Matthijs M, King, Neil P, Lovell, Jonathan F, Julien, Jean-Philippe

“…Malaria transmission-blocking vaccines (TBVs) aim to elicit human antibodies that inhibit sporogonic development of Plasmodium falciparum in mosquitoes,…”
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Adjuvanting a subunit COVID-19 vaccine to induce protective immunity by Arunachalam, Prabhu S., Walls, Alexandra C., Golden, Nadia, Atyeo, Caroline, Fischinger, Stephanie, Li, Chunfeng, Aye, Pyone, Navarro, Mary Jane, Lai, Lilin, Edara, Venkata Viswanadh, Röltgen, Katharina, Rogers, Kenneth, Shirreff, Lisa, Ferrell, Douglas E., Wrenn, Samuel, Pettie, Deleah, Kraft, John C., Miranda, Marcos C., Kepl, Elizabeth, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, White, Alexander G., Trisal, Meera, Hsieh, Ching-Lin, Russell-Lodrigue, Kasi, Monjure, Christopher, Dufour, Jason, Spencer, Skye, Doyle-Meyers, Lara, Bohm, Rudolph P., Maness, Nicholas J., Roy, Chad, Plante, Jessica A., Plante, Kenneth S., Zhu, Alex, Gorman, Matthew J., Shin, Sally, Shen, Xiaoying, Fontenot, Jane, Gupta, Shakti, O’Hagan, Derek T., Van Der Most, Robbert, Rappuoli, Rino, Coffman, Robert L., Novack, David, McLellan, Jason S., Subramaniam, Shankar, Montefiori, David, Boyd, Scott D., Flynn, JoAnne L., Alter, Galit, Villinger, Francois, Kleanthous, Harry, Rappaport, Jay, Suthar, Mehul S., King, Neil P., Veesler, David, Pulendran, Bali

“…The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative 1 . Here we demonstrate the…”
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Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens by Kraft, John C, Pham, Minh N, Shehata, Laila, Brinkkemper, Mitch, Boyoglu-Barnum, Seyhan, Sprouse, Kaitlin R, Walls, Alexandra C, Cheng, Suna, Murphy, Mike, Pettie, Deleah, Ahlrichs, Maggie, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ellis, Daniel, Ravichandran, Rashmi, Fiala, Brooke, Wrenn, Samuel, Miranda, Marcos, Sliepen, Kwinten, Brouwer, Philip J M, Antanasijevic, Aleksandar, Veesler, David, Ward, Andrew B, Kanekiyo, Masaru, Pepper, Marion, Sanders, Rogier W, King, Neil P

“…Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs, and several have established records of clinical safety and efficacy…”
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Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection by Crawford, Katharine H D, Dingens, Adam S, Eguia, Rachel, Wolf, Caitlin R, Wilcox, Naomi, Logue, Jennifer K, Shuey, Kiel, Casto, Amanda M, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, King, Neil P, Greninger, Alexander L, Chu, Helen Y, Bloom, Jesse D

“…Most individuals infected with SARS-CoV-2 develop neutralizing antibodies that target the viral spike protein. Here we quantify how levels of these antibodies…”
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