Search Results - "Petry, Sabine"

Mechanisms of Mitotic Spindle Assembly by Petry, Sabine

“…Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ∼200…”
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Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation by King, Matthew R., Petry, Sabine

“…Phase separation of substrates and effectors is proposed to enhance biological reaction rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector…”
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Structural analysis of the role of TPX2 in branching microtubule nucleation by Alfaro-Aco, Raymundo, Thawani, Akanksha, Petry, Sabine

“…The mitotic spindle consists of microtubules (MTs), which are nucleated by the γ-tubulin ring complex (γ-TuRC). How the γ-TuRC gets activated at the right time…”
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Building the Microtubule Cytoskeleton Piece by Piece by Alfaro-Aco, Ray, Petry, Sabine

“…The microtubule (MT) cytoskeleton gives cells their shape, organizes the cellular interior, and segregates chromosomes. These functions rely on the precise…”
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Biochemical reconstitution of branching microtubule nucleation by Alfaro-Aco, Raymundo, Thawani, Akanksha, Petry, Sabine

“…Microtubules are nucleated from specific locations at precise times in the cell cycle. However, the factors that constitute these microtubule nucleation…”
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HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2 by Valdez, Venecia Alexandria, Ma, Meisheng, Gouveia, Bernardo, Zhang, Rui, Petry, Sabine

“…In vertebrate spindles, most microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing…”
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Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2 by Petry, Sabine, Groen, Aaron C., Ishihara, Keisuke, Mitchison, Timothy J., Vale, Ronald D.

“…The microtubules that comprise mitotic spindles in animal cells are nucleated at centrosomes and by spindle assembly factors that are activated in the vicinity…”
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Spatiotemporal organization of branched microtubule networks by Thawani, Akanksha, Stone, Howard A, Shaevitz, Joshua W, Petry, Sabine

“…To understand how chromosomes are segregated, it is necessary to explain the precise spatiotemporal organization of microtubules (MTs) in the mitotic spindle…”
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Motorless transport of microtubules along tubulin, RanGTP, and salt gradients by Shim, Suin, Gouveia, Bernardo, Ramm, Beatrice, Valdez, Venecia A., Petry, Sabine, Stone, Howard A.

“…Microtubules are dynamic filaments that assemble spindles for eukaryotic cell division. As the concentration profiles of soluble tubulin and regulatory…”
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Structural basis of protein condensation on microtubules underlying branching microtubule nucleation by Guo, Changmiao, Alfaro-Aco, Raymundo, Zhang, Chunting, Russell, Ryan W., Petry, Sabine, Polenova, Tatyana

“…Targeting protein for Xklp2 (TPX2) is a key factor that stimulates branching microtubule nucleation during cell division. Upon binding to microtubules (MTs),…”
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augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells by Uehara, Ryota, Nozawa, Ryu-suke, Tomioka, Akiko, Petry, Sabine, Vale, Ronald D, Obuse, Chikashi, Goshima, Gohta

“…The mitotic spindle is constructed from microtubules (MTs) nucleated from centrosomes, chromosome proximal regions, and preexisting spindle MTs. Augmin, a…”
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The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy by Thawani, Akanksha, Rale, Michael J, Coudray, Nicolas, Bhabha, Gira, Stone, Howard A, Shaevitz, Joshua W, Petry, Sabine

“…Determining how microtubules (MTs) are nucleated is essential for understanding how the cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex…”
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Integrated model of the vertebrate augmin complex by Travis, Sophie M., Mahon, Brian P., Huang, Wei, Ma, Meisheng, Rale, Michael J., Kraus, Jodi, Taylor, Derek J., Zhang, Rui, Petry, Sabine

“…Accurate segregation of chromosomes is required to maintain genome integrity during cell division. This feat is accomplished by the microtubule-based spindle…”
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Uniform intensity in multifocal microscopy using a spatial light modulator by Amin, M Junaid, Petry, Sabine, Yang, Haw, Shaevitz, Joshua W

“…Multifocal microscopy (MFM) offers high-speed three-dimensional imaging through the simultaneous image capture from multiple focal planes. Conventional MFM…”
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Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract by Gouveia, Bernardo, Setru, Sagar U., King, Matthew R., Hamlin, Aaron, Stone, Howard A., Shaevitz, Joshua W., Petry, Sabine

“…Microtubules are generated at centrosomes, chromosomes, and within spindles during cell division. Whereas microtubule nucleation at the centrosome is well…”
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The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC) by Rale, Michael J, Romer, Brianna, Mahon, Brian P, Travis, Sophie M, Petry, Sabine

“…To establish the microtubule cytoskeleton, the cell must tightly regulate when and where microtubules are nucleated. This regulation involves controlling the…”
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Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts by Petry, Sabine, Pugieux, Céline, Nédélec, François J, Vale, Ronald D

“…Female meiotic spindles in many organisms form in the absence of centrosomes, the organelle typically associated with microtubule (MT) nucleation. Previous…”
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A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches by Setru, Sagar U, Gouveia, Bernardo, Alfaro-Aco, Raymundo, Shaevitz, Joshua W, Stone, Howard A, Petry, Sabine

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Electronic Energy Migration in Microtubules by Kalra, Aarat P., Benny, Alfy, Travis, Sophie M., Zizzi, Eric A., Morales-Sanchez, Austin, Oblinsky, Daniel G., Craddock, Travis J. A., Hameroff, Stuart R., MacIver, M. Bruce, Tuszyński, Jack A., Petry, Sabine, Penrose, Roger, Scholes, Gregory D.

“…The repeating arrangement of tubulin dimers confers great mechanical strength to microtubules, which are used as scaffolds for intracellular macromolecular…”
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Crystal structure of the ribosome recycling factor bound to the ribosome by Ramakrishnan, V, Dunham, Christine M, Kelley, Ann C, Weixlbaumer, Albert, Petry, Sabine, Selmer, Maria

“…In bacteria, disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF), which…”
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