Search Results - "Petruk, Svetlana"

Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation by Petruk, Svetlana, Cai, Jingli, Sussman, Robyn, Sun, Guizhi, Kovermann, Sina K., Mariani, Samanta A., Calabretta, Bruno, McMahon, Steven B., Brock, Hugh W., Iacovitti, Lorraine, Mazo, Alexander

“…Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation…”
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Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference by Petruk, Svetlana, Sedkov, Yurii, Riley, Kristen M., Hodgson, Jacob, Schweisguth, Francois, Hirose, Susumu, Jaynes, James B., Brock, Hugh W., Mazo, Alexander

“…Much of the genome is transcribed into long noncoding RNAs (ncRNAs). Previous data suggested that bithoraxoid ( bxd) ncRNAs of the Drosophila bithorax complex…”
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Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification by Petruk, Svetlana, Mariani, Samanta A., De Dominici, Marco, Porazzi, Patrizia, Minieri, Valentina, Cai, Jingli, Iacovitti, Lorraine, Flomenberg, Neal, Calabretta, Bruno, Mazo, Alexander

“…The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs…”
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Fibrosis-the tale of H3K27 histone methyltransferases and demethylases by Basta, Morgan D, Petruk, Svetlana, Mazo, Alexander, Walker, Janice L

“…Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation…”
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Detection of RNA-DNA association by a proximity ligation-based method by Petruk, Svetlana, Fenstermaker, Tyler K., Black, Kathryn L., Brock, Hugh W., Mazo, Alexander

“…We describe a proximity ligation assay (PLA)-based method of assessing association of DNA and RNA in single cells during the cell cycle. Pulse-labeling of DNA…”
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Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis by Basta, Morgan D., Petruk, Svetlana, Summer, Ross, Rosenbloom, Joel, Wermuth, Peter J., Macarak, Edward, Levin, Alex V., Mazo, Alexander, Walker, Janice L.

“…Cell reprogramming to a myofibroblast responsible for the pathological accumulation of extracellular matrix is fundamental to the onset of fibrosis. Here, we…”
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Transcriptional interference: an unexpected layer of complexity in gene regulation by Mazo, Alexander, Hodgson, Jacob W, Petruk, Svetlana, Sedkov, Yurii, Brock, Hugh W

“…Much of the genome is transcribed into long untranslated RNAs, mostly of unknown function. Growing evidence suggests that transcription of sense and antisense…”
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Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex by Mazo, Alexander, Smith, Sheryl T, Petruk, Svetlana, Sedkov, Yurii, Cho, Elizabeth, Tillib, Sergei, Canaani, Eli

“…Rapid induction of the Drosophila melanogaster heat shock gene hsp70 is achieved through the binding of heat shock factor (HSF) to heat shock elements (HSEs)…”
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Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70 by Li, Taosui, Hodgson, Jacob W, Petruk, Svetlana, Mazo, Alexander, Brock, Hugh W

“…Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and…”
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Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila by Mazo, Alexander, Sedkov, Yurii, Cho, Elizabeth, Petruk, Svetlana, Cherbas, Lucy, Smith, Sheryl T, Jones, Richard S, Cherbas, Peter, Canaani, Eli, Jaynes, James B

“…Steroid hormones fulfil important functions in animal development. In Drosophila, ecdysone triggers moulting and metamorphosis through its effects on gene…”
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Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity by Petruk, Svetlana, Smith, Sheryl T, Sedkov, Yurii, Mazo, Alexander

“…Polycomb group (PcG) and trithorax group (trxG) proteins act in an epigenetic fashion to maintain active and repressive states of expression of the Hox and…”
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A Model for Initiation of Mosaic HOX Gene Expression Patterns by Non-Coding RNAs in Early Embryos by Petruk, Svetlana, Sedkov, Yurii, Brock, Hugh W., Mazo, Alexander

“…There is growing appreciation for the role of non-coding (nc) RNA in regulation of HOX genes of Drosophila. Our data suggest that current models for activation…”
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Trithorax- and Polycomb-Group Response Elements within an Ultrabithorax Transcription Maintenance Unit Consist of Closely Situated but Separable Sequences by Tillib, Sergei, Petruk, Svetlana, Sedkov, Yurii, Kuzin, Alexander, Fujioka, Miki, Goto, Tadaatsu, Mazo, Alexander

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RNA polymerase II associates with active genes during DNA replication by Fenstermaker, Tyler K., Petruk, Svetlana, Kovermann, Sina K., Brock, Hugh W., Mazo, Alexander

“…The transcriptional machinery is thought to dissociate from DNA during replication. Certain proteins, termed epigenetic marks, must be transferred from parent…”
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An emerging paradigm in epigenetic marking: coordination of transcription and replication by Fenstermaker, Tyler K, Petruk, Svetlana, Mazo, Alexander

“…DNA replication and RNA transcription both utilize DNA as a template and therefore need to coordinate their activities. The predominant theory in the field is…”
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Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs by De Dominici, Marco, Porazzi, Patrizia, Xiao, Youcai, Chao, Allen, Tang, Hsin-Yao, Kumar, Gaurav, Fortina, Paolo, Spinelli, Orietta, Rambaldi, Alessandro, Peterson, Luke F., Petruk, Svetlana, Barletta, Camilla, Mazo, Alexander, Cingolani, Gino, Salvino, Joseph M., Calabretta, Bruno

“…Expression of the cell cycle regulatory gene CDK6 is required for Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) cell growth, whereas…”
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TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication by Petruk, Svetlana, Sedkov, Yurii, Johnston, Danika M., Hodgson, Jacob W., Black, Kathryn L., Kovermann, Sina K., Beck, Samantha, Canaani, Eli, Brock, Hugh W., Mazo, Alexander

“…Propagation of gene-expression patterns through the cell cycle requires the existence of an epigenetic mark that re-establishes the chromatin architecture of…”
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Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression by Porazzi, Patrizia, Petruk, Svetlana, Pagliaroli, Luca, De Dominici, Marco, Deming, 2nd, David, Puccetti, Matthew V, Kushinsky, Saul, Kumar, Gaurav, Minieri, Valentina, Barbieri, Elisa, Deliard, Sandra, Grande, Alexis, Trizzino, Marco, Gardini, Alessandro, Canaani, Eli, Palmisiano, Neil, Porcu, Pierluigi, Ertel, Adam, Fortina, Paolo, Eischen, Christine M, Mazo, Alexander, Calabretta, Bruno

“…Despite treatment with intensive chemotherapy, acute myelogenous leukemia (AML) remains an aggressive malignancy with a dismal outcome in most patients. We…”
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A Proximity Ligation-Based Method to Detect RNA-DNA Association by Fenstermaker, Tyler K, Sun, Guizhi, Mazo, Alexander, Petruk, Svetlana

“…We recently developed a method for assessing RNA-DNA interactions using proximity ligation assays (PLA). This technique, termed the "RNA-DNA interaction assay"…”
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Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication by Petruk, Svetlana, Black, Kathryn L., Kovermann, Sina K., Brock, Hugh W., Mazo, Alexander

“…The mechanism of epigenetic inheritance following DNA replication may involve dissociation of chromosomal proteins from parental DNA and reassembly on daughter…”
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