Childhood central nervous system tumours – incidence and survival in Europe (1978–1997): Report from Automated Childhood Cancer Information System project

This paper describes the incidence and survival of childhood central nervous system (CNS) tumours in Europe for the period 1978–1997. A total of 19,531 cases, aged 0–14 years, from the ACCIS database were analysed by five regions: the British Isles, East, North, South, and West. Overall age-standard...

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Bibliographic Details
Published in:	European journal of cancer (1990) Vol. 42; no. 13; pp. 2064 - 2080
Main Authors:	Peris-Bonet, Rafael, Martínez-García, Carmen, Lacour, Brigitte, Petrovich, Svetlana, Giner-Ripoll, Begoña, Navajas, Aurora, Steliarova-Foucher, Eva
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2006
Subjects:	Adolescent Central Nervous System Neoplasms - epidemiology Central Nervous System Neoplasms - mortality Central nervous system tumours Child Child, Preschool Childhood cancer Databases, Factual - statistics & numerical data Europe Europe - epidemiology Female Humans Incidence Infant Infant, Newborn Male Population-based cancer registries Registries - statistics & numerical data Survival Survival Analysis Trends Europe Population-based cancer registries Europe Central nervous system tumours Trends Survival Childhood cancer Incidence
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Summary:	This paper describes the incidence and survival of childhood central nervous system (CNS) tumours in Europe for the period 1978–1997. A total of 19,531 cases, aged 0–14 years, from the ACCIS database were analysed by five regions: the British Isles, East, North, South, and West. Overall age-standardised incidence rate (ASR) of CNS tumours in Europe (1988–1997) was 29.9 per million, with the highest rates in the North. Astrocytoma (ASR = 11.8), primitive neuroectodermal tumours (PNET) (ASR = 6.5) and ependymoma (ASR = 3.4) were the most frequent types. Incidence increased significantly during 1978–1997, on average by 1.7% per year. Diagnostic methods may partially explain incidence rates and trends, although a role of variations in risk factors cannot be excluded. Overall 5-year survival was 64% and varied between 72% in the North and 53% in the East. PNET had the poorest prognosis (49%) and astrocytoma the best (75%). Survival has improved by 29% since late 1970s. The positive trends were seen in all regions, although the interregional differences persisted, as a reflection of the different healthcare systems.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2006.05.009