Search Results - "Petrova, Zaritza O."
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Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma
Published in Nature communications (05-05-2023)“…Activating point mutations in Anaplastic Lymphoma Kinase (ALK ) have positioned ALK as the only mutated oncogene tractable for targeted therapy in…”
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On the nature of mycobacteriophage diversity and host preference
Published in Virology (New York, N.Y.) (20-12-2012)“…Abstract The complete genome sequences of over 220 mycobacteriophages reveal them to be highly diverse, with numerous types sharing little or no nucleotide…”
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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
Published in Cell reports (Cambridge) (23-01-2024)“…The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other…”
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A destabilizing Y891D mutation in activated EGFR impairs sensitivity to kinase inhibition
Published in NPJ precision oncology (05-01-2024)“…EGFR tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutated non-small cell lung carcinoma (NSCLC); however, therapeutic resistance…”
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Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography
Published in Proceedings of the National Academy of Sciences - PNAS (05-09-2017)“…Development of resistance remains a major challenge for drugs to treat HIV-1 infections, including those targeting the essential viral polymerase, HIV-1…”
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Mycobacteriophage-repressor-mediated immunity as a selectable genetic marker: Adephagia and BPs repressor selection
Published in Microbiology (Society for General Microbiology) (01-08-2015)“…Mycobacteriophages provide an abundance of systems for use in mycobacterial genetics, including manipulation of Mycobacterium tuberculosis. Because of the…”
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