Search Results - "Petrova, Tatiana V"
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Biological functions of lymphatic vessels
Published in Science (American Association for the Advancement of Science) (10-07-2020)“…Roles of organ-specific lymphatic vessels Lymphatic vessels are spread throughout the human body and have critical functions in mammalian physiology. Petrova…”
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Organ-specific lymphatic vasculature: From development to pathophysiology
Published in The Journal of experimental medicine (02-01-2018)“…Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally…”
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Lymphatic vascular morphogenesis in development, physiology, and disease
Published in The Journal of cell biology (16-05-2011)“…The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance,…”
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High-resolution 3D analysis of mouse small-intestinal stroma
Published in Nature protocols (01-09-2016)“…This protocol describes how to perform whole-mount immunostaining and imaging on adult mouse small-intestinal villi. All gut cell types can be seen at high…”
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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
Published in Proceedings of the National Academy of Sciences - PNAS (15-12-2015)“…Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these…”
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Pressing the right buttons: signaling in lymphangiogenesis
Published in Blood (24-04-2014)“…Lymphatic vasculature is increasingly recognized as an important factor both in the regulation of normal tissue homeostasis and immune response and in many…”
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Stem-cell-like T cells have a specific entry gate to the tumor
Published in Cancer cell (14-03-2022)“…Tumor-infiltrated T cells with stem-cell-like properties are important for determining the immunotherapy response. In this issue of Cancer Cell, Asrir and…”
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Mechanosensitive mTORC1 signaling maintains lymphatic valves
Published in The Journal of cell biology (05-06-2023)“…Homeostatic maintenance and repair of lymphatic vessels are essential for health. We investigated the dynamics and the molecular mechanisms of lymphatic…”
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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Published in Cell stem cell (07-03-2019)“…It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the…”
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Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43
Published in Circulation research (04-01-2019)“…RATIONALE:Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well…”
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Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation
Published in Developmental cell (14-02-2012)“…Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical…”
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Multiple roles of lymphatic vessels in peripheral lymph node development
Published in The Journal of experimental medicine (05-11-2018)“…The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying…”
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FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature
Published in The Journal of clinical investigation (01-10-2015)“…Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with…”
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Biological Basis of Therapeutic Lymphangiogenesis
Published in Circulation (New York, N.Y.) (29-03-2011)Get full text
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ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
Published in Nature communications (09-07-2022)“…The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy…”
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Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice
Published in The Journal of clinical investigation (01-03-2020)“…Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse…”
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GATA2 is required for lymphatic vessel valve development and maintenance
Published in The Journal of clinical investigation (03-08-2015)“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis
Published in Cell reports (Cambridge) (08-10-2019)“…Multiple sclerosis (MS) is a common autoimmune disease of the CNS. Although an association between MS and inflammatory bowel diseases is observed, the link…”
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Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation
Published in eLife (08-06-2020)“…Mutations in the transcription factor are predominately associated with lymphedema. Herein, we demonstrate a key role for related factor FOXC1, in addition to…”
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c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs
Published in The Journal of experimental medicine (05-12-2022)“…Small intestinal villi are structural and functional units present in higher vertebrates and uniquely adapted to nutrient absorption. Villus enterocytes are…”
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