Search Results - "Petroulakis, E"

mTOR, translation initiation and cancer by Mamane, Y, Petroulakis, E, LeBacquer, O, Sonenberg, N

“…Control of mRNA translation plays a fundamental role in many aspects of cell metabolism. It constitutes a critical step in the control of gene expression, and…”
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mTOR signaling: implications for cancer and anticancer therapy by PETROULAKIS, E, MAMANE, Y, LE BACQUER, O, SHAHBAZIAN, D, SONENBERG, N

“…Mounting evidence links deregulated protein synthesis to tumorigenesis via the translation initiation factor complex eIF4F. Components of this complex are…”
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Patterns for the design of secure and dependable software defined networks by Petroulakis, Nikolaos E., Spanoudakis, George, Askoxylakis, Ioannis G.

“…In an interconnected world, cyber and physical networks face a number of challenges that need to be resolved. These challenges are mainly due to the nature and…”
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Blockchain-based Electronic Patient Records for Regulated Circular Healthcare Jurisdictions by Alexaki, Sofia, Alexandris, George, Katos, Vasilis, Petroulakis, Nikolaos E.

“…Circular, data-driven healthcare is increasingly being considered as an effective model to provide efficient, cost-effective and sustainable healthcare…”
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mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs by Dowling, Ryan J.O, Topisirovic, Ivan, Alain, Tommy, Bidinosti, Michael, Fonseca, Bruno D, Petroulakis, Emmanuel, Wang, Xiaoshan, Larsson, Ola, Selvaraj, Anand, Liu, Yi, Kozma, Sara C, Thomas, George, Sonenberg, Nahum

“…The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogen and nutrient signals to control cell proliferation and cell size. Hence, mTORC1 is…”
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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression by Furic, Luc, Rong, Liwei, Larsson, Ola, Koumakpayi, Ismaël Hervé, Yoshida, Kaori, Brueschke, Andrea, Petroulakis, Emmanuel, Robichaud, Nathaniel, Pollak, Michael, Gaboury, Louis A., Pandolfi, Pier Paolo, Saad, Fred, Sonenberg, Nahum, Mak, Tak Wah

“…Translational regulation plays a critical role in the control of cell growth and proliferation. A key player in translational control is eIF4E, the mRNA 5'…”
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Life-logging in smart environments: Challenges and security threats by Petroulakis, N. E., Askoxylakis, I. G., Tryfonas, T.

“…As the world becomes an interconnected network in which objects and humans interact, new challenges and threats appear. In this interconnected world, smart…”
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eIF4E - from translation to transformation by Mamane, Yaël, Petroulakis, Emmanuel, Rong, Liwei, Yoshida, Kaori, Ler, Lian Wee, Sonenberg, Nahum

“…Over the years, studies have focused on the transcriptional regulation of oncogenesis. More recently, a growing emphasis has been placed on translational…”
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Atrophy of S6K1 −/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control by Sotiropoulos, Athanassia, Pende, Mario, Ohanna, Mickaël, Sobering, Andrew K, Lapointe, Thomas, Lorenzo, Lazaro, Praud, Christophe, Petroulakis, Emmanuel, Sonenberg, Nahum, Kelly, Paul A

“…The mammalian target of rapamycin (mTOR) and Akt proteins regulate various steps of muscle development and growth, but the physiological relevance and the…”
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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation by Mamane, Yaël, Petroulakis, Emmanuel, Martineau, Yvan, Sato, Taka-Aki, Larsson, Ola, Rajasekhar, Vinagolu K, Sonenberg, Nahum

“…Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5' cap-binding protein, plays…”
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XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation by Shaffer, A.L, Shapiro-Shelef, Miriam, Iwakoshi, Neal N, Lee, Ann-Hwee, Qian, Shu-Bing, Zhao, Hong, Yu, Xin, Yang, Liming, Tan, Bruce K, Rosenwald, Andreas, Hurt, Elaine M, Petroulakis, Emmanuel, Sonenberg, Nahum, Yewdell, Jonathan W, Calame, Kathryn, Glimcher, Laurie H, Staudt, Louis M

“…The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression…”
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Motor function analysis of myelin mutant mice using a rotarod by Kuhn, P L, Petroulakis, E, Zazanis, G A, McKinnon, R D

“…We have examined motor control in normal and shiverer mutant mice using the rotarod assay, a forced motor activity which tests for balance and co-ordination…”
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helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis by Parsyan, Armen, Shahbazian, David, Martineau, Yvan, Petroulakis, Emmanuel, Alain, Tommy, Larsson, Ola, Mathonnet, Geraldine, Tettweiler, Gritta, Hellen, Christopher U, Pestova, Tatyana V, Svitkin, Yuri V, Sonenberg, Nahum

“…Translational control plays an important role in cell growth and tumorigenesis. Cap-dependent translation initiation of mammalian mRNAs with structured 5'UTRs…”
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p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs by Petroulakis, Emmanuel, Parsyan, Armen, Dowling, Ryan J.O., LeBacquer, Olivier, Martineau, Yvan, Bidinosti, Michael, Larsson, Ola, Alain, Tommy, Rong, Liwei, Mamane, Yaël, Paquet, Marilene, Furic, Luc, Topisirovic, Ivan, Shahbazian, David, Livingstone, Mark, Costa-Mattioli, Mauro, Teodoro, Jose G., Sonenberg, Nahum

“…eIF4E, the mRNA 5′ cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and…”
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Validation of Semantic Interoperability between IoT Platforms by Lakka, Eftychia, Petroulakis, Nikolaos E., Michalodimitrakis, Emmanouil, Papoutsakis, Emmanouil

“…The growing trend towards the exchange of data between heterogeneous objects and platforms have increased the level of complexity in the Internet of Things…”
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End-to-End Semantic Interoperability Mechanisms for IoT by Lakka, Eftychia, Petroulakis, Nikolaos E., Hatzivasilis, George, Soultatos, Othonas, Michalodimitrakis, Manolis, Rak, Urszula, Waledzik, Karolina, Anicic, Darko, Kulkarni, Vivek

“…Semantic interoperability is the designed property where various systems can interact with each other and exchange data with unambiguous, shared meaning. This…”
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mTOR, translation initiation and cancer: mTOR signalling by MAMANE, Y, PETROULAKIS, E, LEBACQUER, O, SONENBERG, N

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Characterization of Elongation Factor-1A (eEF1A-1) and eEF1A-2/S1 Protein Expression in Normal and wasted Mice by Khalyfa, Abdelnaby, Bourbeau, Denis, Chen, Edwin, Petroulakis, Emmanuel, Pan, Jie, Xu, Suying, Wang, Eugenia

“…The eEF1Α-2 gene (S1) encodes a tissue-specific isoform of peptide elongation factor-1A (eEF1A-1); its mRNA is expressed only in brain, heart, and skeletal…”
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mTOR signaling: implications for cancer and anticancer therapy by Petroulakis, E, Mamane, Y, Le Bacquer, O, Shahbazian, D, Sonenberg, N

“…Mounting evidence links deregulated protein synthesis to tumorigenesis via the translation initiation factor complex eIF4F. Components of this complex are…”
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Reactive security for SDN/NFV‐enabled industrial networks leveraging service function chaining by Petroulakis, Nikolaos E., Fysarakis, Konstantinos, Askoxylakis, Ioannis, Spanoudakis, George

“…The innovative application of fifth‐generation core technologies, ie, software‐defined networking (SDN) and network function virtualization, can help reduce…”
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