Search Results - "Petroula Proitsi"

The key role of apolipoprotein B in major vascular diseases and longevity by Proitsi, Petroula

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Metabolomic correlates of central adiposity and earlier-life body mass index by Wulaningsih, Wahyu, Proitsi, Petroula, Wong, Andrew, Kuh, Diana, Hardy, Rebecca

“…BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from…”
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Risk of developing dementia in people with diabetes and mild cognitive impairment by Velayudhan, Latha, Poppe, Michaela, Archer, Nicola, Proitsi, Petroula, Brown, Richard G., Lovestone, Simon

“…Diabetes mellitus is associated with cognitive dysfunction, but it is not clear whether the disorder increases the risk of conversion from mild cognitive…”
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Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing by Ghosh, Anshua, Mizuno, Keiko, Tiwari, Sachin S., Proitsi, Petroula, Gomez Perez-Nievas, Beatriz, Glennon, Elizabeth, Martinez-Nunez, Rocio T., Giese, K. Peter

“…Alzheimer’s disease (AD) is characterised by Aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. Previous…”
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Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology by Sattlecker, Martina, Kiddle, Steven J, Newhouse, Stephen, Proitsi, Petroula, Nelson, Sally, Williams, Stephen, Johnston, Caroline, Killick, Richard, Simmons, Andrew, Westman, Eric, Hodges, Angela, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Lovestone, Simon, Dobson, Richard J.B

“…Abstract Blood proteins and their complexes have become the focus of a great deal of interest in the context of their potential as biomarkers of Alzheimer's…”
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Inflammatory proteins in plasma are associated with severity of Alzheimer's disease by Leung, Rufina, Proitsi, Petroula, Simmons, Andrew, Lunnon, Katie, Güntert, Andreas, Kronenberg, Deborah, Pritchard, Megan, Tsolaki, Magda, Mecocci, Patrizia, Kloszewska, Iwona, Vellas, Bruno, Soininen, Hilkka, Wahlund, Lars-Olaf, Lovestone, Simon

“…Markers of Alzheimer's disease (AD) are being widely sought with a number of studies suggesting blood measures of inflammatory proteins as putative biomarkers…”
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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease by Kim, Min, Nevado-Holgado, Alejo, Whiley, Luke, Snowden, Stuart G, Soininen, Hilkka, Kloszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Thambisetty, Madhav, Dobson, Richard J B, Powell, John F, Lupton, Michelle K, Simmons, Andy, Velayudhan, Latha, Lovestone, Simon, Proitsi, Petroula, Legido-Quigley, Cristina

“…Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery…”
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Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study by Kiddle, Steven J, Sattlecker, Martina, Proitsi, Petroula, Simmons, Andrew, Westman, Eric, Bazenet, Chantal, Nelson, Sally K, Williams, Stephen, Hodges, Angela, Johnston, Caroline, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Newhouse, Stephen, Lovestone, Simon, Dobson, Richard J B

“…A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of Alzheimer's disease (AD) would have great utility;…”
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Smell identification function as a severity and progression marker in Alzheimer's disease by Velayudhan, Latha, Pritchard, Megan, Powell, John F, Proitsi, Petroula, Lovestone, Simon

“…Olfactory dysfunction, impaired smell identification in particular, is known as a diagnostic and a marker of conversion in Alzheimer's disease (AD). We aimed…”
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Urinary metabolic phenotyping for Alzheimer’s disease by Kurbatova, Natalja, Garg, Manik, Whiley, Luke, Chekmeneva, Elena, Jiménez, Beatriz, Gómez-Romero, María, Pearce, Jake, Kimhofer, Torben, D’Hondt, Ellie, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Aarsland, Dag, Nevado-Holgado, Alejo, Liu, Benjamine, Snowden, Stuart, Proitsi, Petroula, Ashton, Nicholas J., Hye, Abdul, Legido-Quigley, Cristina, Lewis, Matthew R., Nicholson, Jeremy K., Holmes, Elaine, Brazma, Alvis, Lovestone, Simon

“…Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies…”
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Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative by Zettergren, Anna, Lord, Jodie, Ashton, Nicholas J, Benedet, Andrea L, Karikari, Thomas K, Lantero Rodriguez, Juan, Snellman, Anniina, Suárez-Calvet, Marc, Proitsi, Petroula, Zetterberg, Henrik, Blennow, Kaj

“…Recent studies suggest that plasma phosphorylated tau181 (p-tau181) is a highly specific biomarker for Alzheimer's disease (AD)-related tau pathology. It has…”
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Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer's Disease by Handy, Alex, Lord, Jodie, Green, Rebecca, Xu, Jin, Aarsland, Dag, Velayudhan, Latha, Hye, Abdul, Dobson, Richard, Proitsi, Petroula

“…Blood plasma proteins have been associated with Alzheimer's disease (AD), but understanding which proteins are on the causal pathway remains challenging…”
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Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease by Velayudhan, Latha, Proitsi, Petroula, Westman, Eric, Muehlboeck, J-Sebastian, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kłoszewska, Iwona, Soininen, Hilkka, Spenger, Christian, Hodges, Angela, Powell, John, Lovestone, Simon, Simmons, Andrew

“…Biomarkers for Alzheimer's disease (AD) based on non-invasive methods are highly desirable for diagnosis, disease progression, and monitoring therapeutics. We…”
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Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis by Proitsi, Petroula, Lupton, Michelle K, Velayudhan, Latha, Newhouse, Stephen, Fogh, Isabella, Tsolaki, Magda, Daniilidou, Makrina, Pritchard, Megan, Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Vellas, Bruno, Williams, Julie, Stewart, Robert, Sham, Pak, Lovestone, Simon, Powell, John F

“…Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and…”
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HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B by Seto, Wai-Kay, Wong, Danny Ka-Ho, Kopaniszen, Malgorzata, Proitsi, Petroula, Sham, Pak-Chung, Hung, Ivan Fan-Ngai, Fung, James, Lai, Ching-Lung, Yuen, Man-Fung

“…Background. The roles of single-nucleotide polymorphisms (SNPs) at HLA-DP and IL28B loci on hepatitis B surface antigen (HBsAg) seroclearance in chronic…”
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Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease by Xu, Jin, Bankov, Giulia, Kim, Min, Wretlind, Asger, Lord, Jodie, Green, Rebecca, Hodges, Angela, Hye, Abdul, Aarsland, Dag, Velayudhan, Latha, Dobson, Richard J B, Proitsi, Petroula, Legido-Quigley, Cristina

“…There is an urgent need to understand the pathways and processes underlying Alzheimer's disease (AD) for early diagnosis and development of effective…”
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Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence by de Lucia, Chiara, Murphy, Tytus, Steves, Claire J., Dobson, Richard J. B., Proitsi, Petroula, Thuret, Sandrine

“…Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked…”
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Plasma proteomic profiles of UK Biobank participants with multiple sclerosis by Jacobs, Benjamin M., Vickaryous, Nicola, Giovannoni, Gavin, Proitsi, Petroula, Waters, Sheena, Dobson, Ruth

“…Objective We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to explore protein biomarkers of disease severity using radiological…”
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Complement activation as a biomarker for Alzheimer's disease by Aiyaz, Mohammed, Lupton, Michelle K, Proitsi, Petroula, Powell, John F, Lovestone, Simon

“…Abstract There is increasing evidence from genetic, immunohistochemical, proteomic and epidemiological studies as well as in model systems that complement…”
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Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease by Green, Rebecca E, Lord, Jodie, Scelsi, Marzia A, Xu, Jin, Wong, Andrew, Naomi-James, Sarah, Handy, Alex, Gilchrist, Lachlan, Williams, Dylan M, Parker, Thomas D, Lane, Christopher A, Malone, Ian B, Cash, David M, Sudre, Carole H, Coath, William, Thomas, David L, Keuss, Sarah, Dobson, Richard, Legido-Quigley, Cristina, Fox, Nick C, Schott, Jonathan M, Richards, Marcus, Proitsi, Petroula

“…Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for…”
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