Search Results - "Petroff, John T."

Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1 by Schmidpeter, Philipp A. M., Petroff, John T., Khajoueinejad, Leila, Wague, Aboubacar, Frankfater, Cheryl, Cheng, Wayland W. L., Nimigean, Crina M., Riegelhaupt, Paul M.

“…Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and shape cellular excitability. For the mechanosensitive subfamily of K2Ps,…”
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Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel by Dalal, Vikram, Arcario, Mark J., Petroff, John T., Tan, Brandon K., Dietzen, Noah M., Rau, Michael J., Fitzpatrick, James A. J., Brannigan, Grace, Cheng, Wayland W. L.

“…Lipid nanodiscs have become a standard tool for studying membrane proteins, including using single particle cryo-electron microscopy (cryo-EM). We find that…”
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Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel by Tong, Ailing, Petroff, 2nd, John T, Hsu, Fong-Fu, Schmidpeter, Philipp Am, Nimigean, Crina M, Sharp, Liam, Brannigan, Grace, Cheng, Wayland Wl

“…Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic…”
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Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels by Cheng, Wayland W L, Arcario, Mark J, Petroff, 2nd, John T

“…Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by…”
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Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation by Petroff, John T., Dietzen, Noah M., Santiago-McRae, Ezry, Deng, Brett, Washington, Maya S., Chen, Lawrence J., Trent Moreland, K., Deng, Zengqin, Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng, Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace, Cheng, Wayland W. L.

“…Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid…”
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Asymmetric Dibenzothiophene Sulfones as Fluorescent Nuclear Stains by Skubic, Kristin N, Arnatt, Christopher K, McCulla, Ryan D

“…Asymmetric dibenzothiophene S,S-dioxides (DBTOOs) were synthesized and their photophysical properties examined. Through examination, the molecules fluoresced…”
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Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites by Dietzen, Noah M, Arcario, Mark J, Chen, Lawrence J, Petroff, 2nd, John T, Moreland, K Trent, Krishnan, Kathiresan, Brannigan, Grace, Covey, Douglas F, Cheng, Wayland Wl

“…Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA,…”
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Photochemistry of N‐Phenyl Dibenzothiophene Sulfoximine by Isor, Ankita, Hommelsheim, Renè, Cone, Grant W., Frings, Marcus, Petroff, John T., Bolm, Carsten, McCulla, Ryan D.

“…Sulfoximines are popular scaffolds in drug discovery due to their hydrogen bonding properties and chemical stability. In recent years, the role of reactive…”
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Dibenzothiophene Sulfone Derivatives as Plasma Membrane Dyes by Petroff, John T., Grady, Scott, Arnatt, Christopher K., McCulla, Ryan D.

“…Dibenzothiophene 5,5‐dioxide (DBTOO) derivatives have recently been shown to processes utility as fluorescent cell dyes. In an effort to extend the…”
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Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts by Tong, Ailing, Chen, Lawrence J, Dekoster, Gregory T, Khan, Farha, Abramson, Jeff, Frieden, Carl, Cheng, Wayland W. L

“…Native mass spectrometry (MS) provides the capacity to monitor membrane protein complexes and noncovalent binding of ligands and lipids to membrane proteins…”
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Effects of photodeoxygenation on cell biology using dibenzothiophene S-oxide derivatives as O( 3 P)-precursors by Isor, Ankita, O'Dea, Austin T, Grady, Scott F, Petroff, 2nd, John T, Skubic, Kristin N, Aziz, Bashar, Arnatt, Christopher K, McCulla, Ryan D

“…Photodeoxygenation of dibenzothiophene S-oxide and its derivatives have been used to generate atomic oxygen [O( P)] to examine its effect on proteins, nucleic…”
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In vitro oxidations of low-density lipoprotein and RAW 264.7 cells with lipophilic O( 3 P)-precursors by Petroff, 2nd, John T, Isor, Ankita, Chintala, Satyanarayana M, Albert, Carolyn J, Franke, Jacob D, Weinstein, David, Omlid, Sara M, Arnatt, Christopher K, Ford, David A, McCulla, Ryan D

“…A beneficial property of photogenerated reactive oxygen species (ROS) is the capability of oxidant generation within a specific location or organelle inside a…”
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Synthesis of triphenylphosphonium dibenzothiophene S-oxide derivatives and their effect on cell cycle as photodeoxygenation-based cytotoxic agents by Isor, Ankita, O'Dea, Austin T., Petroff, John T., Skubic, Kristin N., Grady, Scott F., Arnatt, Christopher K., McCulla, Ryan D.

“…•First example of photodeoxygenation being used to induce cell death.•Loss of single oxygen atom after photodeoxygenation has large effect of the compoud’s…”
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Enhanced photocatalytic dehalogenation of aryl halides by combined poly-p-phenylene (PPP) and TiO2 photocatalysts by Petroff II, John T., Nguyen, Anh H., Porter, Alex J., Morales, Fraisher D., Kennedy, Michael P., Weinstein, David, Nazer, Hossam El, McCulla, Ryan D.

“…[Display omitted] •Irradiation of poly-p-phenylene (PPP) with visible light resulted in the dehalogenation of aryl bromides and chlorides.•Combining PPP with…”
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Nanodisc scaffold alters the structure of a pentameric ligand-gated ion channel revealing new conformations by Dalal, Vikram, Petroff, John T., Dietzen, Noah M., Cheng, Wayland W.

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Photo-oxidation and Thermal Oxidations of Triptycene Thiols by Aryl Chalcogen Oxides by Chintala, Satyanarayana M, Maness, Peter F, Throgmorton, John C, Zhang, Miao, Omlid, Sara M, McCulla, Ryan D

“…Oxidation of thiols yield sulfenic acids, which are very unstable intermediates. As sulfenic acids are reactive, they form disulfides in the presence of…”
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Absolute binding affinities of phospholipids to Erwinia ligand-gated ion channel (ELIC) by streamlined alchemical free energy perturbations (SAFEP) by Santiago-McRae, Ezry, Petroff, John T., Cheng, Wayland W., Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace

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Wavelength dependent photochemistry of expanded chromophore and asymmetric dibenzothiophene S-Oxide derivatives by Petroff, John T., Omlid, Sara M., Chintala, Satyanarayana M., McCulla, Ryan D.

“…[Display omitted] •Irradiation of aryl and sulfonate ester substituted dibenzothiophene S-oxides exhibit wavelength dependent photochemistry.•Upon irradiation…”
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Photodeoxygenation of phenanthro[4,5-bcd]thiophene S-oxide, triphenyleno[1,12-bcd]thiophene S-oxide and perylo[1,12-bcd]thiophene S-oxide by Chintala, Satyanarayana M., Petroff II, John T., Barnes, Andrew, McCulla, Ryan D.

“…Sulfoxides, upon irradiation with ultraviolet (UV) light undergo α-cleavage, hydrogen abstraction, photodeoxygenation, bimolecular photoreduction, and…”
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Reactions of sulfenic acids with amines, thiols, and thiolates studied by quantum chemical calculations by Petroff, John T., Omlid, Sara M., Haloi, Nandan, Sith, Louis, Johnson, Shaquina, McCulla, Ryan D.

“…[Display omitted] •Amines and thiols had front-side approach, 75˚ angle of attack, assists proton transfer.•Thiolates favored back-side approach, flat…”
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