Search Results - "Petris, M J"

Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function by Dos Santos, H.T., Nam, K., Brown, C.T., Dean, S.M., Lewis, S., Pfeifer, C.S., Lei, P., Petris, M.J., Andreadis, S.T., Baker, O.J.

“…New strategies for tissue engineering have great potential for restoring and revitalizing impaired tissues and organs, including the use of smart hydrogels…”
Get full text

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells by Greenough, M, Pase, L, Voskoboinik, I, Petris, M J, O'Brien, A Wilson, Camakaris, J

“…The Menkes protein (MNK; ATP7A) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut…”
Get more information

Ligand‐regulated transport of the Menkes copper P‐type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking by Petris, M. J, Mercer, J. F, Culvenor, J. G, Lockhart, P, Gleeson, P. A, Camakaris, J

“…The Menkes P‐type ATPase (MNK), encoded by the Menkes gene (MNK; ATP7A), is a transmembrane copper‐translocating pump which is defective in the human disorder…”
Get full text

A copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase by Kim, B-E, Smith, K, Petris, M J

“…Copper dependency in humans is most dramatically illustrated in Menkes disease, an X linked recessive copper deficiency disorder that is generally lethal in…”
Get full text

The Menkes Protein (ATP7A; MNK) Cycles via the Plasma Membrane Both in Basal and Elevated Extracellular Copper Using a C-Terminal Di-Leucine Endocytic Signal by Petris, Michael J., Mercer, Julian F.B.

“…Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A (MNK) gene which encodes a coppertransporting P-type ATPase…”
Get full text

A C-Terminal Di-Leucine is Required for Localization of the Menkes Protein in the trans-Golgi Network by Petris, Michael J., Camakaris, James, Greenough, Mark, LaFontaine, Sharon, Mercer, Julian F. B.

“…The human X-linked recessive disorder of copper metabolism, Menkes disease, is caused by a defect in the MNK (ATP7A) gene which encodes a transmembrane…”
Get full text

Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches by Lutsenko, S, Petris, M J

“…Copper is an essential trace element that plays a very important role in cell physiology. In humans, disruption of normal copper homeostasis leads to severe…”
Get full text

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux by Camakaris, J, Petris, M J, Bailey, L, Shen, P, Lockhart, P, Glover, T W, Barcroft, C, Patton, J, Mercer, J F

“…Three copper-resistant variants of cultured Chinese hamster ovary (CHO) cells were isolated and each was shown to accumulate less intracellular copper than the…”
Get more information

P2Y2R deletion ameliorates sialadenitis in IL‐14α‐transgenic mice by Woods, LT, Camden, JM, Khalafalla, MG, Petris, MJ, Erb, L, Ambrus, JL, Weisman, GA

“…Objective Interleukin‐14α‐transgenic (IL‐14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including…”
Get full text

P2Y 2 R deletion ameliorates sialadenitis in IL-14α-transgenic mice by Woods, L T, Camden, J M, Khalafalla, M G, Petris, M J, Erb, L, Ambrus, Jr, J L, Weisman, G A

“…Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and…”
Get full text

The Menkes copper transporter is required for the activation of tyrosinase by Petris, M J, Strausak, D, Mercer, J F

“…Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A (MNK) gene. The MNK gene encodes a copper-transporting…”
Get full text

The Menkes copper transporter is required for the activation of tyrosinase by PETRIS, Michael J, STRAUSAK, Daniel, MERCER, Julian F. B

Get full text

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking by Petris, M. J., Mercer, J. F., Culvenor, J. G., Lockhart, P., Gleeson, P. A., Camakaris, J.

Get full text

Correction of the Copper Transport Defect of Menkes Patient Fibroblasts by Expression of the Menkes and Wilson ATPases by Fontaine, Sharon La, Firth, Stephen D., Camakaris, James, Englezou, Anna, Theophilos, Michael B., Petris, Michael J., Howie, Michelle, Lockhart, Paul J., Greenough, Mark, Brooks, Hilary, Reddel, Roger R., Mercer, Julian F.B.

“…Menkes' disease is a fatal, X-linked, copper deficiency disorder that results from defective copper efflux from intestinal cells and inadequate copper delivery…”
Get full text

P2Y2 R deletion ameliorates sialadenitis in IL-14α-transgenic mice by Woods, L T, Camden, J M, Khalafalla, M G, Petris, M J, Erb, L, Ambrus, J L, Weisman, G A

“…OBJECTIVEInterleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including…”
Get full text

Phenotypic diversity of Menkes disease in mottled mice is associated with defects in localisation and trafficking of the ATP7A protein by Kim, Byung-Eun, Petris, Michael J

“…Owing to mutations in the copper-transporting P-type ATPase, ATP7A (or MNK), patients with Menkes disease (MD) have an inadequate supply of copper to various…”
Get full text

Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1 by Petris, Michael J, Smith, Kathryn, Lee, Jaekwon, Thiele, Dennis J

“…Copper uptake at the plasma membrane and subsequent delivery to copper-dependent enzymes is essential for many cellular processes, including mitochondrial…”
Get full text

The SLC31 (Ctr) copper transporter family by Petris, Michael J

“…Copper is essential for many copper-dependent processes, including mitochondrial oxidative phosphorylation, free-radical detoxification, pigmentation,…”
Get full text

Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system by Lee, Jaekwon, Petris, Michael J, Thiele, Dennis J

“…The trace metal copper is an essential cofactor for a number of enzymes that have critical roles in biological processes, but it is highly toxic when allowed…”
Get full text

Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter by Guo, Yan, Smith, Kathryn, Lee, Jaekwon, Thiele, Dennis J., Petris, Michael J.

“…Copper uptake and subsequent delivery to copper-dependent enzymes are essential for many cellular processes. However, the intracellular levels of this nutrient…”
Get full text