Search Results - "Petrini, Massimiliano"

The Renewal of Cancer Immunotherapy by Bulgarelli, Jenny, Pignatta, Sara, Petrini, Massimiliano, Ridolfi, Laura

“…Cancer immunotherapy embraces many current, promising therapeutic approaches to eradicate tumors by activating host antitumor activity [...]…”
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Potency Assessment of Dendritic Cell Anticancer Vaccine: Validation of the Co-Flow DC Assay by Carloni, Silvia, Piccinini, Claudia, Pancisi, Elena, Soldati, Valentina, Stefanelli, Monica, Granato, Anna Maria, Ibrahim, Toni, Petrini, Massimiliano

“…For many years, oncological clinical trials have taken advantage of dendritic cells (DC) for the design of DC-based cellular therapies. This has required the…”
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Dendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors by Bulgarelli, Jenny, Tazzari, Marcella, Granato, Anna Maria, Ridolfi, Laura, Maiocchi, Serena, de Rosa, Francesco, Petrini, Massimiliano, Pancisi, Elena, Gentili, Giorgia, Vergani, Barbara, Piccinini, Filippo, Carbonaro, Antonella, Leone, Biagio Eugenio, Foschi, Giovanni, Ancarani, Valentina, Framarini, Massimo, Guidoboni, Massimo

“…Dendritic cell (DC)-based vaccination effectively induces anti-tumor immunity, although in the majority of cases this does not translate into a durable…”
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First step results from a phase II study of a dendritic cell vaccine in glioblastoma patients (CombiG-vax) by Ridolfi, Laura, Gurrieri, Lorena, Riva, Nada, Bulgarelli, Jenny, De Rosa, Francesco, Guidoboni, Massimo, Fausti, Valentina, Ranallo, Nicoletta, Calpona, Sebastiano, Tazzari, Marcella, Petrini, Massimiliano, Granato, Anna Maria, Pancisi, Elena, Foca, Flavia, D'Allagata, Monia, Bondi, Isabella, Amadori, Elena, Cortesi, Pietro, Zani, Chiara, Ancarani, Valentina, Gamboni, Alessandro, Polselli, Antonio, Pasini, Giuseppe, Bartolini, Daniela, Maimone, Giuseppe, Arpa, Donatella, Tosatto, Luigino

“…Glioblastoma (GBM) is a poor prognosis grade 4 glioma. After surgical resection, the standard therapy consists of concurrent radiotherapy (RT) and temozolomide…”
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Radiotherapy and High-Dose Interleukin-2: Clinical and Immunological Results of a Proof of Principle Study in Metastatic Melanoma and Renal Cell Carcinoma by Bulgarelli, Jenny, Piccinini, Claudia, Petracci, Elisabetta, Pancisi, Elena, Granato, Anna Maria, de Rosa, Francesco, Guidoboni, Massimo, Petrini, Massimiliano, Ancarani, Valentina, Foschi, Giovanni, Romeo, Antonino, Tontini, Luca, De Giorgi, Ugo, Lolli, Cristian, Gentili, Giorgia, Valmorri, Linda, Rossi, Alice, Ferroni, Fabio, Casadei, Carla, Cortesi, Pietro, Crudi, Laura, Ridolfi, Laura

“…High-dose interleukin-2 (HD IL-2) has curative potential in metastatic melanoma (MM) and renal cell carcinoma (RCC). Radiotherapy (RT) kills cancer cells and…”
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Stability Program in Dendritic Cell Vaccines: A “Real-World” Experience in the Immuno-Gene Therapy Factory of Romagna Cancer Center by Pancisi, Elena, Granato, Anna Maria, Scarpi, Emanuela, Ridolfi, Laura, Carloni, Silvia, Moretti, Cinzia, Guidoboni, Massimo, De Rosa, Francesco, Pignatta, Sara, Piccinini, Claudia, Soldati, Valentina, Calabrò, Luana, Framarini, Massimo, Stefanelli, Monica, Bulgarelli, Jenny, Tazzari, Marcella, Fanini, Francesca, Petrini, Massimiliano

“…Advanced therapy medical products (ATMPs) are rapidly growing as innovative medicines for the treatment of several diseases. Hence, the role of quality…”
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Evaluation of in vivo labelled dendritic cell migration in cancer patients by Ridolfi, Ruggero, Riccobon, Angela, Galassi, Riccardo, Giorgetti, Gianluigi, Petrini, Massimiliano, Fiammenghi, Laura, Stefanelli, Monica, Ridolfi, Laura, Moretti, Andrea, Migliori, Giuseppe, Fiorentini, Giuseppe

“…BACKGROUND: Dendritic Cell (DC) vaccination is a very promising therapeutic strategy in cancer patients. The immunizing ability of DC is critically influenced…”
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Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients by Ridolfi, Ruggero, Petrini, Massimiliano, Fiammenghi, Laura, Stefanelli, Monica, Ridolfi, Laura, Ballardini, Michela, Migliori, Giuseppe, Riccobon, Angela

“…We present our experience of therapeutic vaccination using dendritic cells (DC) pulsed with autologous tumor antigens in patients with advanced melanoma…”
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Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis by Migliori, Giuseppe, Tauceri, Francesca, Verdecchia, Giorgio Maria, Riccobon, Angela, Ridolfi, Ruggero, Guidoboni, Massimo, Scarpi, Emanuela, Pancisi, Elena, Ancarani, Valentina, Granato, Anna Maria, Fiammenghi, Laura, Petrini, Massimiliano, Ridolfi, Laura, Sanna, Stefano

“…We reviewed the clinical results of a dendritic cell-based phase II clinical vaccine trial in stage IV melanoma and analyzed a patient subgroup treated with…”
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FRET microscopy autologous tumor lysate processing in mature dendritic cell vaccine therapy by Fiammenghi, Laura, Ancarani, Valentina, Rosales, Tilman, Knutson, Jay R, Petrini, Massimiliano, Granato, Anna Maria, Pancisi, Elena, Ridolfi, Laura, Ridolfi, Ruggero, Riccobon, Angela, Neyroz, Paolo

“…Antigen processing by dendritic cells (DC) exposed to specific stimuli has been well characterized in biological studies. Nonetheless, the question of whether…”
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A New Gene Family Including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: Characterization from Yeast to Human and Identification of DSCR1-like 2, a Novel Human Member (DSCR1L2) by Strippoli, Pierluigi, Lenzi, Luca, Petrini, Massimiliano, Carinci, Paolo, Zannotti, Maria

“…A new gene family has been identified on the basis of in-depth bioinformatics analysis of the Down syndrome candidate region 1 (DSCR1) gene, located on…”
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Erratum to “Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis” by Migliori, Giuseppe, Tauceri, Francesca, Verdecchia, Giorgio Maria, Riccobon, Angela, Valmorri, Linda, Ridolfi, Ruggero, Guidoboni, Massimo, Scarpi, E., Pancisi, Elena, Ancarani, Valentina, Granato, Anna Maria, Fiammenghi, Laura, Petrini, Massimiliano, Ridolfi, Laura, Sanna, Stefano

“…The authors would like to add Dr. LindaValmorriat to the authors' list. Thus, the authors' list will be:Laura Ridolfi, Massimiliano Petrini, Laura Fiammenghi,…”
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In vitro CAR-T cell killing: validation of the potency assay by Piccinini, Claudia, Carloni, Silvia, Arienti, Chiara, Pancisi, Elena, Fanini, Francesca, Pignatta, Sara, Soldati, Valentina, Stefanelli, Monica, Granato, Anna Maria, Martinelli, Giovanni, Ridolfi, Laura, Petrini, Massimiliano

“…For advanced therapy medicinal products, the development and validation of potency assays are required, in accordance with international guidelines, to…”
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Results from the first step of a phase II study of vaccination with autologous dendritic cells loaded with autologous tumour homogenate in glioblastoma by Ridolfi, Laura, Gurrieri, Lorena, Riva, Nada, Bulgarelli, Jenny, De Rosa, Francesco, Guidoboni, Massimo, Fausti, Valentina, Ranallo, Nicoletta, Tazzari, Marcella, Petrini, Massimiliano, Granato, Anna Maria, Pancisi, Elena, Foca, Flavia, Dall'Agata, Monia, Amadori, Elena, Cortesi, Pietro, Gamboni, Alessandro, Pasini, Giuseppe, Ibrahim, Toni, Tosatto, Luigino

“…e14025 Background: Glioblastoma (GBM) is a poor prognosis malignant grade IV glioma. After surgical resection, standard therapy consists of concomitant…”
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Dendritic cell vaccines as cancer treatment: focus on 13 years of manufacturing and quality control experience in advanced therapy medicinal products by Granato, Anna Maria, Pancisi, Elena, Piccinini, Claudia, Stefanelli, Monica, Pignatta, Sara, Soldati, Valentina, Carloni, Silvia, Fanini, Francesca, Arienti, Chiara, Bulgarelli, Jenny, Tazzari, Marcella, Scarpi, Emanuela, Passardi, Alessandro, Tauceri, Francesca, La Barba, Giuliano, Maimone, Giuseppe, Baravelli, Stefano, de Rosa, Francesco, Ridolfi, Laura, Petrini, Massimiliano

“…Dendritic cells (DCs) are professional antigen-presenting cells of the mammalian immune system. Ex vivo differentiated DCs represent a unique Advanced Therapy…”
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Skewing effect of sulprostone on dendritic cell maturation compared with dinoprostone by Bulgarelli, Jenny, Fiammenghi, Laura, Cassan, Serena, Granato, Anna Maria, Petrini, Massimiliano, Pancisi, Elena, Soldati, Valentina, De Rosa, Francesco, Ridolfi, Laura, Riccobon, Angela, Guidoboni, Massimo

“…Abstract Background Dendritic cells (DCs) are the most efficient antigen-presenting cells and act at the center of the immune system owing to their ability to…”
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Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T-cells in advanced melanoma patients by Ridolfi, Laura, Petrini, Massimiliano, Granato, Anna Maria, Gentilcore, Giusy, Simeone, Ester, Ascierto, Paolo Antonio, Pancisi, Elena, Ancarani, Valentina, Fiammenghi, Laura, Guidoboni, Massimo, de Rosa, Francesco, Valmorri, Linda, Scarpi, Emanuela, Nicoletti, Stefania Vittoria Luisa, Baravelli, Stefano, Riccobon, Angela, Ridolfi, Ruggero

“…In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive…”
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Complementary vaccination protocol with dendritic cells pulsed with autologous tumour lysate in patients with resected stage III or IV melanoma: protocol for a phase II randomised trial (ACDC Adjuvant Trial) by Ridolfi, Laura, de Rosa, Francesco, Fiammenghi, Laura, Petrini, Massimiliano, Granato, Anna Maria, Ancarani, Valentina, Pancisi, Elena, Soldati, Valentina, Cassan, Serena, Bulgarelli, Jenny, Riccobon, Angela, Gentili, Giorgia, Nanni, Oriana, Framarini, Massimo, Tauceri, Francesca, Guidoboni, Massimo

“…IntroductionSurgery is one of the treatments of choice for patients with a single metastasis from melanoma but is rarely curative. Such patients could…”
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Dendritic cell vaccination for metastatic melanoma: a 14-year monoinstitutional experience by de Rosa, Francesco, Ridolfi, Laura, Fiammenghi, Laura, Petrini, Massimiliano, Granato, Anna M, Ancarani, Valentina, Pancisi, Elena, Soldati, Valentina, Cassan, Serena, Bulgarelli, Jenny, Framarini, Massimo, Tauceri, Francesca, Migliori, Giuseppe, Brolli, Claudia, Gentili, Giorgia, Petracci, Elisabetta, Nanni, Oriana, Riccobon, Angela, Ridolfi, Ruggero, Guidoboni, Massimo

“…Although immunomodulating antibodies are highly effective in metastatic melanoma, their toxicity, related to the activation of T lymphocytes, can be severe…”
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Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-α in patients with metastatic melanoma: a randomised "proof-of-principle" phase II study by de Rosa, Francesco, Ridolfi, Laura, Ridolfi, Ruggero, Gentili, Giorgia, Valmorri, Linda, Nanni, Oriana, Petrini, Massimiliano, Fiammenghi, Laura, Granato, Anna Maria, Ancarani, Valentina, Pancisi, Elena, Soldati, Valentina, Cassan, Serena, Riccobon, Angela, Parisi, Elisabetta, Romeo, Antonino, Turci, Livia, Guidoboni, Massimo

“…Vaccination with dendritic cells (DC) loaded with tumor antigens elicits tumor-specific immune responses capable of killing cancer cells without inducing…”
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