Search Results - "Petrella, Stéphanie"

Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide by Petrella, Stéphanie, Gelus-Ziental, Nathalie, Maudry, Arnaud, Laurans, Caroline, Boudjelloul, Rachid, Sougakoff, Wladimir

“…Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis…”
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A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance by Chauffour, Aurélie, Morel, Florence, Reibel, Florence, Petrella, Stéphanie, Mayer, Claudine, Cambau, Emmanuelle, Aubry, Alexandra

“…The fact that Mycobacterium leprae does not grow in vitro remains a challenge in the survey of its antimicrobial resistance (AMR). Mainly molecular methods are…”
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The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG by Weiß, Manuela, Giacomelli, Giacomo, Assaya, Mathilde Ben, Grundt, Finja, Haouz, Ahmed, Peng, Feng, Petrella, Stéphanie, Wehenkel, Anne Marie, Bramkamp, Marc

“…Abstract Cells are continuously facing the risk of taking up foreign DNA that can compromise genomic integrity. Therefore, bacteria are in a constant arms race…”
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Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase by Piton, Jérémie, Petrella, Stéphanie, Delarue, Marc, André-Leroux, Gwénaëlle, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine

“…Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in…”
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New Mutations in the Mycobacterial ATP Synthase: New Insights into the Binding of the Diarylquinoline TMC207 to the ATP Synthase C-Ring Structure by Segala, Elena, Sougakoff, Wladimir, Nevejans-Chauffour, Aurelie, Jarlier, Vincent, Petrella, Stephanie

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Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity by Petrella, Stéphanie, Capton, Estelle, Raynal, Bertrand, Giffard, Clément, Thureau, Aurélien, Bonneté, Françoise, Alzari, Pedro M., Aubry, Alexandra, Mayer, Claudine

“…Despite sharing common features, previous studies have shown that gyrases from different species have been modified throughout evolution to modulate their…”
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Extending the Definition of the GyrB Quinolone Resistance-Determining Region in Mycobacterium tuberculosis DNA Gyrase for Assessing Fluoroquinolone Resistance in M. tuberculosis by PANTEL, Alix, PETRELLA, Stéphanie, VEZIRIS, Nicolas, BROSSIER, Florence, BASTIAN, Sylvaine, JARLIER, Vincent, MAYER, Claudine, AUBRY, Alexandra

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Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization by Kerff, Frédéric, Amoroso, Ana, Herman, Raphaël, Sauvage, Eric, Petrella, Stéphanie, Filée, Patrice, Charlier, Paulette, Joris, Bernard, Tabuchi, Akira, Nikolaidis, Nikolas, Cosgrove, Daniel J

“…We solved the crystal structure of a secreted protein, EXLX1, encoded by the yoaJ gene of Bacillus subtilis. Its structure is remarkably similar to that of…”
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Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states by Takahashi, Diane T., Gadelle, Danièle, Agama, Keli, Kiselev, Evgeny, Zhang, Hongliang, Yab, Emilie, Petrella, Stephanie, Forterre, Patrick, Pommier, Yves, Mayer, Claudine

“…Eukaryotic topoisomerases I (TOP1) are ubiquitous enzymes removing DNA torsional stress. However, there is little data concerning the three-dimensional…”
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Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion by Agrawal, Alka, Roué, Mélanie, Spitzfaden, Claus, Petrella, Stéphanie, Aubry, Alexandra, Hann, Michael, Bax, Benjamin, Mayer, Claudine

“…DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA duplex and transporting another DNA duplex [T-DNA…”
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Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis by Brossier, Florence, Boudinet, Marlène, Jarlier, Vincent, Petrella, Stéphanie, Sougakoff, Wladimir

“…Summary Resistance to isoniazid (INH-R) in Mycobacterium tuberculosis is mainly due to mutations at position 315 (S315T) of the catalase-peroxidase KatG. We…”
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Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead by Bruch, Eduardo M, Petrella, Stephanie, Bellinzoni, Marco

“…Structure-based and computer-aided drug design approaches are commonly considered to have been successful in the fields of cancer and antiviral drug discovery…”
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DNA Gyrase Inhibition Assays Are Necessary To Demonstrate Fluoroquinolone Resistance Secondary to gyrB Mutations in Mycobacterium tuberculosis by PANTEL, Alix, PETRELLA, Stephanie, MATRAT, Stephanie, BROSSIER, Florence, BASTIAN, Sylvaine, REITTER, Delphine, JARLIER, Vincent, MAYER, Claudine, AUBRY, Alexandra

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Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A β-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France by Petrella, Stephanie, Ziental-Gelus, Nathalie, Mayer, Claudine, Renard, Murielle, Jarlier, Vincent, Sougakoff, Wladimir

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Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis by Pantel, Alix, Petrella, Stéphanie, Veziris, Nicolas, Matrat, Stéphanie, Bouige, Aurélie, Ferrand, Hélène, Sougakoff, Wladimir, Mayer, Claudine, Aubry, Alexandra

“…Resistance to fluoroquinolones (FQs) in Mycobacterium tuberculosis (Mtb) is mainly due to mutations in DNA gyrase (GyrA2B2), with the most common substitutions…”
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Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase by Gedeon, Antoine, Yab, Emilie, Dinut, Aurelia, Sadowski, Elodie, Capton, Estelle, Dreneau, Aurore, Petit, Julienne, Gioia, Bruna, Piveteau, Catherine, Djaout, Kamel, Lecat, Estelle, Wehenkel, Anne Marie, Gubellini, Francesca, Mechaly, Ariel, Alzari, Pedro M., Deprez, Benoît, Baulard, Alain, Aubry, Alexandra, Willand, Nicolas, Petrella, Stéphanie

“…Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors…”
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Genetic Basis for Natural and Acquired Resistance to the Diarylquinoline R207910 in Mycobacteria by PETRELLA, Stephanie, CAMBAU, Emmanuelle, CHAUFFOUR, Aurelie, ANDRIES, Koen, JARLIER, Vincent, SOUGAKOFF, Wladimir

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Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes by Bouige, Aurélie, Darmon, Amélie, Piton, Jérémie, Roue, Mélanie, Petrella, Stéphanie, Capton, Estelle, Forterre, Patrick, Aubry, Alexandra, Mayer, Claudine

“…In contrast with most bacteria which possess two type II topoisomerases (topoisomerase IV and DNA gyrase), Mycobacterium tuberculosis possesses only one, DNA…”
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Specific Structural Features of the N-Acetylmuramoyl- l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family by Kerff, Frédéric, Petrella, Stéphanie, Mercier, Frédéric, Sauvage, Eric, Herman, Raphaël, Pennartz, Anne, Zervosen, Astrid, Luxen, André, Frère, Jean-Marie, Joris, Bernard, Charlier, Paulette

“…AmiD is the fifth identified N-acetylmuramoyl- l-alanine zinc amidase of Escherichia coli. This periplasmic lipoprotein is anchored in the outer membrane and…”
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Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones by MATRAT, Stéphanie, PETRELLA, Stéphanie, CAMBAU, Emmanuelle, SOUGAKOFF, Wladimir, JARLIER, Vincent, AUBRY, Alexandra

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