Search Results - "Petrella, Diane K"

Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon by Ulrich, Roger G, Bacon, James A, Brass, Eric P, Cramer, Clay T, Petrella, Diane K, Sun, Elena L

“…Preclinical drug safety evaluation studies, typically conducted in two or more animal species, reveal and define dose-dependent toxicities and undesirable…”
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Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Meglasson, Martin D., Holmuhamedov, Ekhson

“…The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human volunteers. Subsequent experimental…”
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Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Peng, Geoffrey W., Petrella, Diane K., Stryd, Ronald P., Sun, Elena L.

“…Drugs can fail at any phase during discovery, preclinical or clinical development due to unacceptable levels of toxicity, and liver is commonly the principle…”
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Inactivation of Serpulina hyodysenteriae flaA1 and flaB1 periplasmic flagellar genes by electroporation-mediated allelic exchange by Rosey, E.L. (Pfizer, Inc., Lincoln, NE.), Kennedy, M.J, Petrella, D.K, Ulrich, R.G, Yancey, R.J. Jr

“…Serpulina hyodysenteriae, the etiologic agent of swine dysentery, contains complex periplasmic flagella which are composed of multiple class A and class B…”
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Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon by Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Ulrich, Roger G.

“…The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular steatosis and centrilobular necrosis…”
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Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic by Ulrich, Roger G., Bacon, James A., Branstetter, Daniel G., Cramer, Clay T., Funk, G.Michael, Hunt, Charles E., Petrella, Diane K., Sun, Elena L.

“…The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in human volunteers that was not…”
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Hepatic changes produced by 30-day administration of a novel aminocyclitol antibiotic, trospectomycin sulfate, to laboratory animals by Ulrich, R G, Petrella, D K, Larsen, E R, Cox, J W, Cramer, C T, Piper, R C, Gray, J E

“…The studies described here were done to characterize the hepatic response to a new aminocyclitol antibiotic, trospectomycin sulfate, administered intravenously…”
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