Search Results - "Petraglia, Francesca"

Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392 by DE BELLIS, Floriana, CARAFA, Vincenzo, GOUBARD, Armelle, COLLETTE, Yves, MANDOLI, Amit, MARTENS, Joost H. A, DE THE, Hugues, NEBBIOSO, Angela, MAI, Antonello, STUNNENBERG, Hendrik G, ALTUCCI, Lucia, CONTE, Mariarosaria, ROTILI, Dante, PETRAGLIA, Francesca, MATARESE, Filomena, FRANCOIJS, Kees-Jan, ABLAIN, Julien, VALENTE, Sergio, CASTELLANO, Rèmy

“…HDAC inhibitors (HDACi) are widely used in the clinic to sensitize tumorigenic cells for treatment with other anticancer compounds. The major drawback of HDACi…”
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The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells by Franci, Gianluigi, Casalino, Laura, Petraglia, Francesca, Miceli, Marco, Menafra, Roberta, Radic, Branka, Tarallo, Valeria, Vitale, Monica, Scarfò, Marzia, Pocsfalvi, Gabriella, Baldi, Alfonso, Ambrosino, Concetta, Zambrano, Nicola, Patriarca, Eduardo, De Falco, Sandro, Minchiotti, Gabriella, Stunnenberg, Hendrik G, Altucci, Lucia

“…Exploitation of embryonic stem cells (ESC) for therapeutic use and biomedical applications is severely hampered by the risk of teratocarcinoma formation. Here,…”
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Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells by Signorile, Pietro G, Petraglia, Francesca, Baldi, Alfonso

“…The anti-mullerian hormone (AMH) is a member of the transforming growth factor β (TGF-β) superfamily, which is responsible of the regression of the mullerian…”
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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes by Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

“…Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and…”
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HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape by Conte, Mariarosaria, Dell'Aversana, Carmela, Benedetti, Rosaria, Petraglia, Francesca, Carissimo, Annamaria, Petrizzi, Valeria Belsito, D'Arco, Alfonso Maria, Abbondanza, Ciro, Nebbioso, Angela, Altucci, Lucia

“…Histone deacetylase 2 (HDAC2) is overexpressed or mutated in several disorders such as hematological cancers, and plays a critical role in transcriptional…”
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MePR: a novel human mesenchymal progenitor model with characteristics of pluripotency by Miceli, Marco, Franci, Gianluigi, Dell'Aversana, Carmela, Ricciardiello, Francesca, Petraglia, Francesca, Carissimo, Annamaria, Perone, Lucia, Maruotti, Giuseppe Maria, Savarese, Marco, Martinelli, Pasquale, Cancemi, Massimo, Altucci, Lucia

“…Human embryo stem cells or adult tissues are excellent models for discovery and characterization of differentiation processes. The aims of regenerative…”
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Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia by Singh, Abhishek A, Petraglia, Francesca, Nebbioso, Angela, Yi, Guoqiang, Conte, Mariarosaria, Valente, Sergio, Mandoli, Amit, Scisciola, Lucia, Lindeboom, Rik, Kerstens, Hinri, Janssen-Megens, Eva M, Pourfarzad, Farzin, Habibi, Ehsan, Berentsen, Kim, Kim, Bowon, Logie, Colin, Heath, Simon, Wierenga, Albertus T J, Clarke, Laura, Flicek, Paul, Jansen, Joop H, Kuijpers, Taco, Yaspo, Marie Laure, Valle, Veronique Della, Bernard, Olivier, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G, Mai, Antonello, Altucci, Lucia, Martens, Joost H A

“…Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL)…”
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Combined HAT/EZH2 modulation leads to cancer-selective cell death by Petraglia, Francesca, Singh, Abhishek A, Carafa, Vincenzo, Nebbioso, Angela, Conte, Mariarosaria, Scisciola, Lucia, Valente, Sergio, Baldi, Alfonso, Mandoli, Amit, Petrizzi, Valeria Belsito, Ingenito, Concetta, De Falco, Sandro, Cicatiello, Valeria, Apicella, Ivana, Janssen-Megens, Eva M, Kim, Bowon, Yi, Guoqiang, Logie, Colin, Heath, Simon, Ruvo, Menotti, Wierenga, Albertus T J, Flicek, Paul, Yaspo, Marie Laure, Della Valle, Veronique, Bernard, Olivier, Tomassi, Stefano, Novellino, Ettore, Feoli, Alessandra, Sbardella, Gianluca, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G, Mai, Antonello, Martens, Joost H A, Altucci, Lucia

“…Epigenetic alterations have been associated with both pathogenesis and progression of cancer. By screening of library compounds, we identified a novel hybrid…”
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