Search Results - "Petra SipilÃ"

The impact of epididymal proteins on sperm function by Björkgren, Ida, Sipilä, Petra

“…The epididymis is necessary for post-testicular sperm maturation as it provides the milieu required for spermatozoa to gain the ability for progressive…”
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Segment-specific regulation of epididymal gene expression by Sipilä, Petra, Björkgren, Ida

“…The epididymis is necessary for post-testicular sperm maturation. During their epididymal transit, spermatozoa gain ability for progressive movement and…”
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction by Zhang, Fu-Ping, Malinen, Marjo, Mehmood, Arfa, Lehtiniemi, Tiina, Jääskeläinen, Tiina, Niskanen, Einari A., Korhonen, Hanna, Laiho, Asta, Elo, Laura L., Ohlsson, Claes, Kotaja, Noora, Poutanen, Matti, Sipilä, Petra, Palvimo, Jorma J.

“…Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or…”
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Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling by Björkgren, Ida, Saastamoinen, Lauri, Krutskikh, Anton, Huhtaniemi, Ilpo, Poutanen, Matti, Sipilä, Petra

“…The postnatal development of the epididymis is a complex process that results in a highly differentiated epithelium, divided into several segments. Recent…”
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Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane by Björkgren, Ida, Gylling, Helena, Turunen, Heikki, Huhtaniemi, Ilpo, Strauss, Leena, Poutanen, Matti, Sipilä, Petra

“…ABSTRACT During epididymal sperm maturation, the lipid content of the sperm membrane is modified, which facilitates sperm motility and fertility. However,…”
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Development of the urogenital system is regulated via the 3′UTR of GDNF by Li, Hao, Jakobson, Madis, Ola, Roxana, Gui, Yujuan, Kumar, Anmol, Sipilä, Petra, Sariola, Hannu, Kuure, Satu, Andressoo, Jaan-Olle

“…Mechanisms controlling ureter lenght and the position of the kidney are poorly understood. Glial cell-line derived neurotrophic factor (GDNF) induced RET…”
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Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness by Morton, Nicholas M, Beltram, Jasmina, Carter, Roderick N, Michailidou, Zoi, Gorjanc, Gregor, McFadden, Clare, Barrios-Llerena, Martin E, Rodriguez-Cuenca, Sergio, Gibbins, Matthew T G, Aird, Rhona E, Moreno-Navarrete, José Maria, Munger, Steven C, Svenson, Karen L, Gastaldello, Annalisa, Ramage, Lynne, Naredo, Gregorio, Zeyda, Maximilian, Wang, Zhao V, Howie, Alexander F, Saari, Aila, Sipilä, Petra, Stulnig, Thomas M, Gudnason, Vilmundur, Kenyon, Christopher J, Seckl, Jonathan R, Walker, Brian R, Webster, Scott P, Dunbar, Donald R, Churchill, Gary A, Vidal-Puig, Antonio, Fernandez-Real, José Manuel, Emilsson, Valur, Horvat, Simon

“…Genetic analysis in mice selected for leanness has identified thiosulfate sulfurtransferase as a target for the treatment of diabetes. The discovery of genetic…”
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Hedgehog-Gli Pathway Activation during Kidney Fibrosis by Fabian, Steven L, Penchev, Radostin R, St-Jacques, Benoit, Rao, Anjali N, Sipilä, Petra, West, Kip A, McMahon, Andrew P, Humphreys, Benjamin D

“…The Hedgehog (Hh) signaling pathway regulates tissue patterning during development, including patterning and growth of limbs and face, but whether Hh signaling…”
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Body‐wide genetic deficiency of poly(ADP‐ribose) polymerase 14 sensitizes mice to colitis by Vedantham, Madhukar, Polari, Lauri, Poosakkannu, Anbu, Pinto, Rita G., Sakari, Moona, Laine, Jukka, Sipilä, Petra, Määttä, Jorma, Gerke, Heidi, Rissanen, Tiia, Rantakari, Pia, Toivola, Diana M., Pulliainen, Arto T.

“…Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and…”
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HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults by Junnila, Arttu, Zhang, Fu-Ping, Martínez Nieto, Guillermo, Hakkarainen, Janne, Mäkelä, Juho-Antti, Ohlsson, Claes, Sipilä, Petra, Poutanen, Matti

“…Abstract Hydroxysteroid (17β) dehydrogenase (HSD17B) enzymes convert 17-ketosteroids to 17beta-hydroxysteroids, an essential step in testosterone biosynthesis…”
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The Finnish genetic heritage in 2022 – from diagnosis to translational research by Uusimaa, Johanna, Kettunen, Johannes, Varilo, Teppo, Järvelä, Irma, Kallijärvi, Jukka, Kääriäinen, Helena, Laine, Minna, Lapatto, Risto, Myllynen, Päivi, Niinikoski, Harri, Rahikkala, Elisa, Suomalainen, Anu, Tikkanen, Ritva, Tyynismaa, Henna, Vieira, Päivi, Zarybnicky, Tomas, Sipilä, Petra, Kuure, Satu, Hinttala, Reetta

“…Isolated populations have been valuable for the discovery of rare monogenic diseases and their causative genetic variants. Finnish disease heritage (FDH) is an…”
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Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts by Huhtaniemi, Riikka, Oksala, Riikka, Knuuttila, Matias, Mehmood, Arfa, Aho, Eija, Laajala, Teemu D., Nicorici, Daniel, Aittokallio, Tero, Laiho, Asta, Elo, Laura, Ohlsson, Claes, Kallio, Pekka, Mäkelä, Sari, Mustonen, Mika V.J., Sipilä, Petra, Poutanen, Matti

“…The role of adrenal androgens as drivers for castration-resistant prostate cancer (CRPC) growth in humans is generally accepted; however, the value of…”
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Immortalized mouse caput epididymal epithelial (mECap18) cell line recapitulates the in‐vivo environment by Mulhall, Jess E., Trigg, Natalie A., Bernstein, Ilana R., Anderson, Amanda L., Murray, Heather C., Sipilä, Petra, Lord, Tessa, Schjenken, John E., Nixon, Brett, Skerrett‐Byrne, David A.

“…Residing between the testes and the vas deferens, the epididymis is a highly convoluted tubule whose unique luminal microenvironment is crucial for the…”
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Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1 by WEI, Yu-Syuan, LIN, Wan-Zhen, WANG, Tse-En, LEE, Wei-Yun, LI, Sheng-Hsiang, LIN, Fu-Jung, NIXON, Brett, SIPILÄ, Petra, TSAI, Pei-Shiue

“…Spermatozoa acquire fertilization ability through post-translational modifications. These membrane surface alterations occur in various segments of the…”
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Scanning transmission soft X-ray spectromicroscopy of mouse kidney and liver by Mansikkala, Tuomas, Ohigashi, Takuji, Salo, Miia H., Hiltunen, Anniina E., Vuolteenaho, Reetta, Sipilä, Petra, Kuure, Satu, Huttula, Marko, Uusimaa, Johanna, Hinttala, Reetta, Miinalainen, Ilkka, Kangas, Salla, Patanen, Minna

“…Scanning transmission X-ray microscopy (STXM) in the soft X-ray range is well-suited to study ultrastructural features of mammalian soft tissues. Especially at…”
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The role of Dicer1 in the male reproductive tract by Björkgren, Ida, Sipilä, Petra

“…Dicer1 is an RNase III enzyme necessary for microRNA (miRNA) biogenesis, as it cleaves pre-miRNAs into mature miRNAs. miRNAs are important regulators of gene…”
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A novel role for milk fat globule‐EGF factor 8 protein (MFGE8) in the mediation of mouse sperm–extracellular vesicle interactions by Trigg, Natalie A., Stanger, Simone J., Zhou, Wei, Skerrett‐Byrne, David A., Sipilä, Petra, Dun, Matthew D., Eamens, Andrew L., De Iuliis, Geoffry N., Bromfield, Elizabeth G., Roman, Shaun D., Nixon, Brett

“…Spermatozoa transition to functional maturity as they are conveyed through the epididymis, a highly specialized region of the male excurrent duct system. Owing…”
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Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia by Mätlik, Kärt, Garton, Daniel R., Montaño-Rodríguez, Ana R., Olfat, Soophie, Eren, Feride, Casserly, Laoise, Damdimopoulos, Anastasios, Panhelainen, Anne, Porokuokka, L. Lauriina, Kopra, Jaakko J., Turconi, Giorgio, Schweizer, Nadine, Bereczki, Erika, Piehl, Fredrik, Engberg, Göran, Cervenka, Simon, Piepponen, T. Petteri, Zhang, Fu-Ping, Sipilä, Petra, Jakobsson, Johan, Sellgren, Carl M., Erhardt, Sophie, Andressoo, Jaan-Olle

“…Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we…”
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Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine by Koli, Katri, Sutinen, Eva, Rönty, Mikko, Rantakari, Pia, Fortino, Vittorio, Pulkkinen, Ville, Greco, Dario, Sipilä, Petra, Myllärniemi, Marjukka

“…Idiopathic pulmonary fibrosis (IPF) is characterized by activation and injury of epithelial cells, the accumulation of connective tissue and changes in the…”
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Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding by Björkgren, Ida, Alvarez, Luis, Blank, Nelli, Balbach, Melanie, Turunen, Heikki, Laajala, Teemu Daniel, Toivanen, Jussi, Krutskikh, Anton, Wahlberg, Niklas, Huhtaniemi, Ilpo, Poutanen, Matti, Wachten, Dagmar, Sipilä, Petra

“…During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin…”
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