Search Results - "Petr Svoboda"

Key Mechanistic Principles and Considerations Concerning RNA Interference by Svoboda, Petr

“…Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-specific RNA degradation induced by long double-stranded RNA (dsRNA)…”
Get full text

Long and small noncoding RNAs during oocyte-to-embryo transition in mammals by Svoboda, Petr

“…Oocyte-to-embryo transition is a process during which an oocyte ovulates, is fertilized, and becomes a developing embryo. It involves the first major genome…”
Get more information

Renaissance of mammalian endogenous RNAi by Svoboda, Petr

“…RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism…”
Get full text

The oocyte-to-embryo transition in mouse: past, present, and future by Schultz, Richard M, Stein, Paula, Svoboda, Petr

“…The oocyte-to-embryo transition (OET) arguably initiates with formation of a primordial follicle and culminates with reprogramming of gene expression during…”
Get full text

Influence of Branching Density in Ethylene-Octene Copolymers on Electron Beam Crosslinkability by Petr Svoboda

“…Two ethylene-octene copolymers (EOC) with the same melt flow index (MFI = 3 g/10 min) but different octene contents, being 20 and 35 wt % (EOC-20 and EOC-35),…”
Get full text

Expression of Opioid Receptors in Cells of the Immune System by Brejchova, Jana, Holan, Vladimir, Svoboda, Petr

“…The observation of the immunomodulatory effects of opioid drugs opened the discussion about possible mechanisms of action and led researchers to consider the…”
Get full text

Influence of thermal degradation on the crystallization of poly(butylene terephthalate) by Nasr, Ahmed, Svoboda, Petr

“…Our work reveals a notable shift in the crystallization temperature (Tc) of poly(butylene terephthalate) (PBT) at which crystallization occurs due to exposure…”
Get full text

Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs by Loubalova, Zuzana, Fulka, Helena, Horvat, Filip, Pasulka, Josef, Malik, Radek, Hirose, Michiko, Ogura, Atsuo, Svoboda, Petr

“…PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. Studies of the pathway in mice have strongly shaped the view that…”
Get full text

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes by Flemr, Matyas, Malik, Radek, Franke, Vedran, Nejepinska, Jana, Sedlacek, Radislav, Vlahovicek, Kristian, Svoboda, Petr

“…In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA) and RNAi pathways. In mice, endogenous RNAi is highly active in…”
Get full text

Influence of Fusion Temperature on Nonisothermal Crystallization Kinetics of Polyamide 6 by Nasr, Ahmed, Svoboda, Petr

“…The effect of fusion temperature and duration on the nonisothermal crystallization kinetics of polyamide 6 (PA6) was investigated using differential scanning…”
Get full text

Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse by Svoboda, Petr, Franke, Vedran, Schultz, Richard M

“…In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to totipotent blastomeres. This transition is driven by degradation…”
Get full text

The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency by Svoboda, Petr, Flemr, Matyas

“…RNA silencing is a complex of mechanisms that regulate gene expression through small RNA molecules. The microRNA (miRNA) pathway is the most common of these in…”
Get full text

Retrotransposon-associated long non-coding RNAs in mice and men by Ganesh, Sravya, Svoboda, Petr

“…Over a half of mammalian genomes is occupied by repetitive elements whose ability to provide functional sequences, move into new locations, and recombine…”
Get full text

Production of small RNAs by mammalian Dicer by Svobodova, Eliska, Kubikova, Jana, Svoboda, Petr

“…MicroRNA (miRNA) and RNA interference (RNAi) pathways employ RNase III Dicer for the biogenesis of small RNAs guiding post-transcriptional repression…”
Get full text

A review of the design and optimization of large-scale hydrostatic bearing systems by Michalec, Michal, Svoboda, Petr, Křupka, Ivan, Hartl, Martin

“…In the last decades, the demand for hydrostatic bearings application has been rising due to the possibilities and advantages they offer. The advancements in…”
Get full text

The Impact of Tax Incentives on Research and Development by Svoboda, Petr

“…The goal of this article is to analyze the impact of tax incentives on research and development and compare its effectiveness to direct government support of…”
Get full text

Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes by Franke, Vedran, Ganesh, Sravya, Karlic, Rosa, Malik, Radek, Pasulka, Josef, Horvat, Filip, Kuzman, Maja, Fulka, Helena, Cernohorska, Marketa, Urbanova, Jana, Svobodova, Eliska, Ma, Jun, Suzuki, Yutaka, Aoki, Fugaku, Schultz, Richard M, Vlahovicek, Kristian, Svoboda, Petr

“…Retrotransposons are "copy-and-paste" insertional mutagens that substantially contribute to mammalian genome content. Retrotransposons often carry long…”
Get full text

The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing by Abe, Ken-ichiro, Yamamoto, Ryoma, Franke, Vedran, Cao, Minjun, Suzuki, Yutaka, Suzuki, Masataka G, Vlahovicek, Kristian, Svoboda, Petr, Schultz, Richard M, Aoki, Fugaku

“…Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic transcription is first detected shortly after pronucleus formation in…”
Get full text

Elastic Electrically Conductive Composites Based on Vapor-Grown Carbon Fibers for Use in Sensors by Nasr, Ahmed, Mrhálek, Ondřej, Svoboda, Petr

“…Elastic electrically conductive composites with an ethylene octene copolymer matrix (EOC) and vapor-grown carbon fibers (VGCF) were prepared by ultrasonication…”
Get full text

Proteomic analysis of protein composition of rat hippocampus exposed to morphine for 10 days; comparison with animals after 20 days of morphine withdrawal by Ujcikova, Hana, Cechova, Kristina, Jagr, Michal, Roubalova, Lenka, Vosahlikova, Miroslava, Svoboda, Petr

“…Opioid addiction is recognized as a chronic relapsing brain disease resulting from repeated exposure to opioid drugs. Cellular and molecular mechanisms…”
Get full text