Search Results - "Peto, Tim E."

Transforming clinical microbiology with bacterial genome sequencing by Didelot, Xavier, Bowden, Rory, Wilson, Daniel J., Peto, Tim E. A., Crook, Derrick W.

“…Key Points Whole-genome sequencing of bacterial isolates is becoming more and more widespread, paving the way for a transformation of many current procedures…”
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Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom by Pritchard, Emma, Matthews, Philippa C., Stoesser, Nicole, Eyre, David W., Gethings, Owen, Vihta, Karina-Doris, Jones, Joel, House, Thomas, VanSteenHouse, Harper, Bell, Iain, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Studley, Ruth, Crook, Derrick, Peto, Tim E. A., Walker, A. Sarah, Pouwels, Koen B.

“…The effectiveness of COVID-19 vaccination in preventing new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is…”
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Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK by Pouwels, Koen B., Pritchard, Emma, Matthews, Philippa C., Stoesser, Nicole, Eyre, David W., Vihta, Karina-Doris, House, Thomas, Hay, Jodie, Bell, John I., Newton, John N., Farrar, Jeremy, Crook, Derrick, Cook, Duncan, Rourke, Emma, Studley, Ruth, Peto, Tim E. A., Diamond, Ian, Walker, A. Sarah

“…The effectiveness of the BNT162b2 and ChAdOx1 vaccines against new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous…”
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Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19 by Mina, Michael J, Peto, Tim E, García-Fiñana, Marta, Semple, Malcolm G, Buchan, Iain E

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Anti-spike antibody response to natural SARS-CoV-2 infection in the general population by Wei, Jia, Matthews, Philippa C., Stoesser, Nicole, Maddox, Thomas, Lorenzi, Luke, Studley, Ruth, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Pouwels, Koen B., Walker, A. Sarah, Eyre, David W.

“…Understanding the trajectory, duration, and determinants of antibody responses after SARS-CoV-2 infection can inform subsequent protection and risk of…”
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Effect of Covid-19 Vaccination on Transmission of Alpha and Delta Variants by Eyre, David W, Taylor, Donald, Purver, Mark, Chapman, David, Fowler, Tom, Pouwels, Koen B, Walker, A. Sarah, Peto, Tim E.A

“…In this study, 37% of 146,000 PCR-tested contacts of infected persons in England were positive for SARS-CoV-2. Transmission of the alpha variant from…”
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Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing by Eyre, David W, Cule, Madeleine L, Wilson, Daniel J, Griffiths, David, Vaughan, Alison, O'Connor, Lily, Ip, Camilla L.C, Golubchik, Tanya, Batty, Elizabeth M, Finney, John M, Wyllie, David H, Didelot, Xavier, Piazza, Paolo, Bowden, Rory, Dingle, Kate E, Harding, Rosalind M, Crook, Derrick W, Wilcox, Mark H, Peto, Tim E.A, Walker, A. Sarah

“…Where does Clostridium difficile come from? In this report from the United Kingdom, of 1223 C. difficile isolates that were evaluated on whole-genome…”
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Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom by Wei, Jia, Stoesser, Nicole, Matthews, Philippa C., Ayoubkhani, Daniel, Studley, Ruth, Bell, Iain, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Pouwels, Koen B., Eyre, David W., Walker, A. Sarah

“…We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection…”
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Relationship Between Bacterial Strain Type, Host Biomarkers, and Mortality in Clostridium difficile Infection by Walker, A. Sarah, Eyre, David W., Wyllie, David H., Dingle, Kate E., Griffiths, David, Shine, Brian, Oakley, Sarah, O'Connor, Lily, Finney, John, Vaughan, Alison, Crook, Derrick W., Wilcox, Mark H., Peto, Tim E. A.

“…Background. Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using…”
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Mortality risks associated with emergency admissions during weekends and public holidays: an analysis of electronic health records by Walker, A Sarah, Prof, Mason, Amy, DPhil, Quan, T Phuong, MSc, Fawcett, Nicola J, MBChB, Watkinson, Peter, MD, Llewelyn, Martin, Prof, Stoesser, Nicole, DPhil, Finney, John, MSc, Davies, Jim, Prof, Wyllie, David H, DPhil, Crook, Derrick W, Prof, Peto, Tim E A, Prof

“…Summary Background Weekend hospital admission is associated with increased mortality, but the contributions of varying illness severity and admission time to…”
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Asymptomatic Clostridium difficile colonisation and onward transmission by Eyre, David W, Griffiths, David, Vaughan, Alison, Golubchik, Tanya, Acharya, Milind, O'Connor, Lily, Crook, Derrick W, Walker, A Sarah, Peto, Tim E A

“…Combined genotyping/whole genome sequencing and epidemiological data suggest that in endemic settings only a minority of Clostridium difficile infection, CDI,…”
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Covert dissemination of carbapenemase-producing Klebsiella pneumoniae (KPC) in a successfully controlled outbreak: long- and short-read whole-genome sequencing demonstrate multiple genetic modes of transmission by Martin, Jessica, Phan, Hang T T, Findlay, Jacqueline, Stoesser, Nicole, Pankhurst, Louise, Navickaite, Indre, De Maio, Nicola, Eyre, David W, Toogood, Giles, Orsi, Nicolas M, Kirby, Andrew, Young, Nicola, Turton, Jane F, Hill, Robert L R, Hopkins, Katie L, Woodford, Neil, Peto, Tim E A, Walker, A Sarah, Crook, Derrick W, Wilcox, Mark H

“…Carbapenemase-producing Enterobacteriaceae (CPE), including KPC-producing Klebsiella pneumoniae (KPC-Kpn), are an increasing threat to patient safety. To use…”
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Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae : an observational study by De Silva, Dilrini, PhD, Peters, Joanna, MBBS, Cole, Kevin, BSc, Cole, Michelle J, DBMS, Cresswell, Fiona, MBChB, Dean, Gillian, MBChB, Dave, Jayshree, MD, Thomas, Daniel Rh, Foster, Kirsty, MSc, Waldram, Alison, PhD, Wilson, Daniel J, DPhil, Didelot, Xavier, DPhil, Grad, Yonatan H, MD, Crook, Derrick W, Prof, Peto, Tim E A, Prof, Walker, A Sarah, Prof, Paul, John, MD, Eyre, David W, Dr

“…Summary Background New approaches are urgently required to address increasing rates of gonorrhoea and the emergence and global spread of antibiotic-resistant…”
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A Candida auris Outbreak and Its Control in an Intensive Care Setting by Eyre, David W, Sheppard, Anna E, Madder, Hilary, Moir, Ian, Moroney, Ruth, Quan, T. Phuong, Griffiths, David, George, Sophie, Butcher, Lisa, Morgan, Marcus, Newnham, Robert, Sunderland, Mary, Clarke, Tiphanie, Foster, Dona, Hoffman, Peter, Borman, Andrew M, Johnson, Elizabeth M, Moore, Ginny, Brown, Colin S, Walker, A. Sarah, Peto, Tim E.A, Crook, Derrick W, Jeffery, Katie J.M

“…Candida auris is an emerging infectious agent with limited antimicrobial susceptibilities. An outbreak was identified in a neurosciences ICU in the United…”
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The quality of vital signs measurements and value preferences in electronic medical records varies by hospital, specialty, and patient demographics by Jackson, Niall, Woods, Jessica, Watkinson, Peter, Brent, Andrew, Peto, Tim E. A., Walker, A. Sarah, Eyre, David W.

“…We aimed to assess the frequency of value preferences in recording of vital signs in electronic healthcare records (EHRs) and associated patient and hospital…”
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Epidemiology of Clostridium difficile in infants in Oxfordshire, UK: Risk factors for colonization and carriage, and genetic overlap with regional C. difficile infection strains by Stoesser, Nicole, Eyre, David W, Quan, T Phuong, Godwin, Heather, Pill, Gemma, Mbuvi, Emily, Vaughan, Alison, Griffiths, David, Martin, Jessica, Fawley, Warren, Dingle, Kate E, Oakley, Sarah, Wanelik, Kazimierz, Finney, John M, Kachrimanidou, Melina, Moore, Catrin E, Gorbach, Sherwood, Riley, Thomas V, Crook, Derrick W, Peto, Tim E A, Wilcox, Mark H, Walker, A Sarah

“…Approximately 30-40% of children <1 year of age are Clostridium difficile colonized, and may represent a reservoir for adult C. difficile infections (CDI)…”
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Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells by Clutterbuck, Elizabeth A., Lazarus, Rajeka, Yu, Ly-Mee, Bowman, Jaclyn, Bateman, Elizabeth A. L., Diggle, Linda, Angus, Brian, Peto, Tim E., Beverley, Peter C., Mant, David, Pollard, Andrew J.

“…Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and…”
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Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples by Votintseva, Antonina A, Bradley, Phelim, Pankhurst, Louise, Del Ojo Elias, Carlos, Loose, Matthew, Nilgiriwala, Kayzad, Chatterjee, Anirvan, Smith, E Grace, Sanderson, Nicolas, Walker, Timothy M, Morgan, Marcus R, Wyllie, David H, Walker, A Sarah, Peto, Tim E A, Crook, Derrick W, Iqbal, Zamin

“…Routine full characterization of is culture based, taking many weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to inform…”
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Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease by Young, Bernadette C, Golubchik, Tanya, Batty, Elizabeth M, Fung, Rowena, Larner-Svensson, Hanna, Votintseva, Antonina A, Miller, Ruth R, Godwin, Heather, Knox, Kyle, Everitt, Richard G, Iqbal, Zamin, Rimmer, Andrew J, Cule, Madeleine, Ip, Camilla L. C, Didelot, Xavier, Harding, Rosalind M, Donnelly, Peter, Peto, Tim E, Crook, Derrick W, Bowden, Rory, Wilson, Daniel J

“…Whole-genome sequencing offers new insights into the evolution of bacterial pathogens and the etiology of bacterial disease. Staphylococcus aureus is a major…”
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Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing by Walker, A Sarah, Eyre, David W, Wyllie, David H, Dingle, Kate E, Harding, Rosalind M, O'Connor, Lily, Griffiths, David, Vaughan, Ali, Finney, John, Wilcox, Mark H, Crook, Derrick W, Peto, Tim E A

“…Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhoea and is endemic in hospitals, hindering the identification of…”
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