Search Results - "Petkus, Jeffrey K"

Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline by Smith, Adrian L, DeMorin, Frenel F, Paras, Nick A, Huang, Qi, Petkus, Jeffrey K, Doherty, Elizabeth M, Nixey, Thomas, Kim, Joseph L, Whittington, Douglas A, Epstein, Linda F, Lee, Matthew R, Rose, Mark J, Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Beltran, Pedro, Carnahan, Josette

“…The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is…”
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Abstract 2681A: Structure-guided design of potent and selective inhibitors of B-Raf kinase displaying on-mechanism in vivo activity by Kim, Joseph L., Smith, Adrian L., Carnahan, Josette, Beltran, Pedro J., Whittington, Douglas A., Rose, Mark J., DeMorin, Frenel, Doherty, Elizabeth, Huang, Qi, Ncube, Mquele, Paras, Nick A., Petkus, Jeffrey K., Tasker, Andrew S., Lee, Matthew R., Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Epstein, Linda F., Yakowec, Peter S.

“…Abstract The Ras-Raf-MAPK signaling pathway plays a central role in diverse cellular processes including differentiation, proliferation and survival. This…”
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