Search Results - "Petkov, Petko I"

Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity by Petkov, Petko I., Schultz, Terry W., Donner, E. Maria, Honma, Masamitsu, Morita, Takeshi, Hamada, Shuichi, Wakata, Akihiro, Mishima, Masayuki, Maniwa, Jiro, Todorov, Milen, Kaloyanova, Elena, Kotov, Stefan, Mekenyan, Ovanes G.

“…We investigated the performance of an integrated approach to testing and assessment (IATA), designed to cover different genotoxic mechanisms causing cancer and…”
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Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism by Mekenyan, Ovanes G, Petkov, Petko I, Kotov, Stefan V, Stoeva, Stoyanka, Kamenska, Verginia B, Dimitrov, Sabcho D, Honma, Masamitsu, Hayashi, Makoto, Benigni, Romualdo, Donner, E. Maria, Patlewicz, Grace

“…Strategic testing as part of an integrated testing strategy (ITS) to maximize information and avoid the use of animals where possible is fast becoming the norm…”
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Validation of the performance of TIMES genotoxicity models with EFSA pesticide data by Petkov, Petko I, Schultz, Terry W, Honma, Masamitsu, Yamada, Takashi, Kaloyanova, Elena, Mekenyan, Ovanes G

“…Abstract This study validates the performance of the TIssue MEtabolism Simulator (TIMES) genotoxicity models with data on pesticide chemicals included in a…”
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A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? by Petkov, Petko I., Patlewicz, Grace, Schultz, Terry W., Honma, Masamitsu, Todorov, Milen, Kotov, Stefan, Dimitrov, Sabcho D., Donner, E. Maria, Mekenyan, Ovanes G.

“…•An in vitro–in vivo extrapolation workflow was adapted to mimic a mechanistic IATA.•Disconcordant outcomes could be mechanistically reasoned.•The IATA was…”
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Procedure for toxicological predictions based on mechanistic weight of evidences: Application to Ames mutagenicity by Petkov, Petko I., Kuseva, Chanita, Kotov, Stefan, Honma, Masamitsu, Kitazawa, Airi, Kulkarni, Sunil, Schultz, Terry W., Mekenyan, Ovanes G.

“…[Display omitted] •A workflow based on mechanistic QSAR, read-across and expert knowledge is proposed.•The workflow is applied to resolve conflicting Ames…”
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