Regulation of the activity of neuron-specific enolase by certain endogenous compounds

The effects of glycolysis metabolites and some amino acids on the activity of bovine brain enolase have been studied. The inhibiting effect of glycolysis metabolites, of which two (2-phosphoglycolate and glyceraldehyde 3-phosphate) may be functionally significant, has been demonstrated. The action m...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 57; no. 12; p. 1827
Main Authors:	Nazarian, K B, Vaĭs, M, Egorin, R U, Kustzheba-Vuĭtsntska, I, Petkevich, Ia
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-12-1992
Subjects:	Amino Acids - physiology Animals Brain - enzymology Cattle gamma-Aminobutyric Acid - physiology Glyceraldehyde 3-Phosphate - physiology Glycolates - metabolism Glycolysis Phosphopyruvate Hydratase - metabolism
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Summary:	The effects of glycolysis metabolites and some amino acids on the activity of bovine brain enolase have been studied. The inhibiting effect of glycolysis metabolites, of which two (2-phosphoglycolate and glyceraldehyde 3-phosphate) may be functionally significant, has been demonstrated. The action mechanisms of these compounds within a range of physiological concentrations as well as the combined effect of glyceraldehyde 3-phosphate and phosphoglyceromutase on enolase activity have been investigated.
ISSN:	0320-9725