Search Results - "Petkau, John"

A parametric model to jointly characterize rate, duration, and severity of exacerbations in episodic diseases by Safari, Abdollah, Petkau, John, FitzGerald, Mark J, Sadatsafavi, Mohsen

“…The natural history of many chronic diseases is characterized by periods of increased disease activity, commonly referred to as flare-ups or exacerbations…”
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Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis by Polman, Chris H, Prof, Bertolotto, Antonio, MD, Deisenhammer, Florian, Prof, Giovannoni, Gavin, Prof, Hartung, Hans-Peter, Prof, Hemmer, Bernhard, Prof, Killestein, Joep, MD, McFarland, Henry F, MD, Oger, Joel, Prof, Pachner, Andrew R, Prof, Petkau, John, Prof, Reder, Anthony T, MD, Reingold, Stephen C, PhD, Schellekens, Huub, Prof, Sørensen, Per Soelberg, Prof

“…Summary The identification of factors that can affect the efficacy of immunomodulatory drugs in relapsing-remitting multiple sclerosis (MS) is important. For…”
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Detection of Unusual Increases in MRI Lesion Counts in Individual Multiple Sclerosis Patients by Zhao, Yinshan, Li, David K. B., Petkau, A. John, Riddehough, Andrew, Traboulsee, Anthony

“…Data Safety and Monitoring Boards (DSMBs) for multiple sclerosis clinical trials consider an increase of contrast-enhancing lesions on repeated magnetic…”
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Non‐parametric inference on calibration of predicted risks by Sadatsafavi, Mohsen, Petkau, John

“…Moderate calibration, the expected event probability among observations with predicted probability z being equal to z, is a desired property of risk prediction…”
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Exposure of chronic obstructive pulmonary disease patients to particles: Respiratory and cardiovascular health effects by Brauer, M, Ebelt, S T, Fisher, T V, Brumm, J, Petkau, A J, Vedal, S

“…To examine hypotheses regarding air pollution health effects, we conducted an exploratory study to evaluate relationships between personal and ambient…”
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Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force by Rudick, R, Antel, J, Confavreux, C, Cutter, G, Ellison, G, Fischer, J, Lublin, F, Miller, A, Petkau, J, Rao, S, Reingold, S, Syndulko, K, Thompson, A, Wallenberg, J, Weinshenker, B, Willoughby, E

“…This article provides recommendations from the National Multiple Sclerosis Society's Clinical Outcomes Assessment Task Force. The Task Force was appointed in…”
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Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children by VEDAL, S, PETKAU, J, WHITE, R, BLAIR, J

“…Although increases in inhalable particle (PM10) concentrations have been associated with acute reductions in the level of lung function and increased symptom…”
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Personalized activity index, a new safety monitoring tool for multiple sclerosis clinical trials by Zhao, Yinshan, Kondo, Yumi, Traboulsee, Anthony, Li, David KB, Riddehough, Andrew, Petkau, A John

“…Background An abnormal increase of contrast-enhancing lesion (CEL) counts on frequent MRIs is interpreted as a signal of potential worsening in multiple…”
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Model-Based ROC Curve: Examining the Effect of Case Mix and Model Calibration on the ROC Plot by Sadatsafavi, Mohsen, Saha-Chaudhuri, Paramita, Petkau, John

“…Background The performance of risk prediction models is often characterized in terms of discrimination and calibration. The receiver-operating characteristic…”
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Role of androgens in women's sexual dysfunction by Basson, Rosemary, Brotto, Lori A., Petkau, A. John, Labrie, Fernand

“…OBJECTIVE:Although suspected, androgen deficit in women with sexual dysfunction has never been established. Given that serum testosterone levels are of limited…”
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Long-Term Natural History of Severe Asthma Exacerbations and Their Impact on the Disease Course by Lee, Tae Yoon, Petkau, John, Sadatsafavi, Mohsen

“…The long-term natural history of asthma in terms of successive severe exacerbations and the influence of each exacerbation on the course of the disease is not…”
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Predictors of Sexual Desire Disorders in Women by Brotto, Lori A., Petkau, A. John, Labrie, Fernand, Basson, Rosemary

“…A historic belief was that testosterone was the “hormone of desire.” However, recent data, which show either minimal or no significant correlation between…”
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Multiple sclerosis: effect of beta interferon treatment on survival by Kingwell, Elaine, Leray, Emmanuelle, Zhu, Feng, Petkau, John, Edan, Gilles, Oger, Joel, Tremlett, Helen

“…See Giovannoni (doi:10.1093/brain/awz101) for a scientific commentary on this article. In this international study of patients with multiple sclerosis,…”
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A longitudinal model for magnetic resonance imaging lesion count data in multiple sclerosis patients by MacKay Altman, Rachel, Petkau, A. John, Vrecko, Dean, Smith, Alex

“…Magnetic resonance imaging (MRI) data are routinely collected at multiple time points during phase 2 clinical trials in multiple sclerosis. However, these data…”
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Identification of treatment responders based on multiple longitudinal outcomes with applications to multiple sclerosis patients by Kondo, Yumi, Zhao, Yinshan, Petkau, John

“…Identification of treatment responders is a challenge in comparative studies where treatment efficacy is measured by multiple longitudinally collected…”
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Defining the clinical course of multiple sclerosis: The 2013 revisions by Lublin, Fred D, Reingold, Stephen C, Cohen, Jeffrey A, Cutter, Gary R, Sørensen, Per Soelberg, Thompson, Alan J, Wolinsky, Jerry S, Balcer, Laura J, Banwell, Brenda, Barkhof, Frederik, Bebo, Bruce, Calabresi, Peter A, Clanet, Michel, Comi, Giancarlo, Fox, Robert J, Freedman, Mark S, Goodman, Andrew D, Inglese, Matilde, Kappos, Ludwig, Kieseier, Bernd C, Lincoln, John A, Lubetzki, Catherine, Miller, Aaron E, Montalban, Xavier, OʼConnor, Paul W, Petkau, John, Pozzilli, Carlo, Rudick, Richard A, Sormani, Maria Pia, Stüve, Olaf, Waubant, Emmanuelle, Polman, Chris H

“…Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of…”
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Comparison of Statistical Approaches for Dealing With Immortal Time Bias in Drug Effectiveness Studies by Karim, Mohammad Ehsanul, Gustafson, Paul, Petkau, John, Tremlett, Helen

“…In time-to-event analyses of observational studies of drug effectiveness, incorrect handling of the period between cohort entry and first treatment exposure…”
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Dealing With Treatment-Confounder Feedback and Sparse Follow-up in Longitudinal Studies: Application of a Marginal Structural Model in a Multiple Sclerosis Cohort by Karim, Mohammad Ehsanul, Tremlett, Helen, Zhu, Feng, Petkau, John, Kingwell, Elaine

“…Abstract The beta-interferons are widely prescribed platform therapies for patients with multiple sclerosis (MS). We accessed a cohort of patients with…”
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Association Between Use of Interferon Beta and Progression of Disability in Patients With Relapsing-Remitting Multiple Sclerosis by Shirani, Afsaneh, Zhao, Yinshan, Karim, Mohammad Ehsanul, Evans, Charity, Kingwell, Elaine, van der Kop, Mia L, Oger, Joel, Gustafson, Paul, Petkau, John, Tremlett, Helen

“…CONTEXT Interferon beta is widely prescribed to treat multiple sclerosis (MS); however, its relationship with disability progression has yet to be established…”
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Should the number of acute exacerbations in the previous year be used to guide treatments in COPD? by Sadatsafavi, Mohsen, McCormack, James, Petkau, John, Lynd, Larry D, Lee, Tae Yoon, Sin, Don D

“…In contemporary management of chronic obstructive pulmonary disease (COPD), the frequent exacerbator phenotype, based on a 12-month history of acute…”
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