Search Results - "Petit, Rebecca S."
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Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2
Published in Science (American Association for the Advancement of Science) (12-03-2010)“…Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on apposed cell surfaces plays important roles in development and exhibits…”
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T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters
Published in Proceedings of the National Academy of Sciences - PNAS (31-05-2011)“…T cells react to extremely small numbers of activating agonist peptides. Spatial organization of T-cell receptors (TCR) and their peptide-major…”
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Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics
Published in Science (American Association for the Advancement of Science) (04-07-2014)“…Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple…”
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EphA2 Receptor Activation by Monomeric Ephrin-A1 on Supported Membranes
Published in Biophysical journal (07-12-2011)“…The receptor tyrosine kinase EphA2 interacts with its glycosylphosphatidylinositol (GPI)-linked ephrin-A1 ligand in a juxtacrine configuration. The soluble…”
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Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling
Published in Nature protocols (01-04-2011)“…Physical inputs, both internal and external to a cell, can directly alter the spatial organization of cell surface receptors and their associated functions…”
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Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells
Published in Journal of cell science (01-02-2012)“…T cell triggering through T-cell antigen receptors (TCRs) results in spatial assembly of the receptors on multiple length scales. This assembly is mediated by…”
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Dissecting T cell receptor nanocluster signaling
Published in Biophysical journal (01-02-2009)Get full text
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Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics
Published in Science (American Association for the Advancement of Science) (04-07-2014)“…Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple…”
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Journal Article