Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study

Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study

The accuracy of the Bactec MGIT 960 system for susceptibility testing of 177 clinical isolates of Mycobacterium tuberculosis to first line drugs (isoniazid, rifampicin, ethambutol and streptomycin) was compared with the agar reference method. The sensitivity, the ability to detect resistance, of the...

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Bibliographic Details
Published in:Journal of microbiological methods Vol. 56; no. 2; pp. 291 - 294
Main Authors: Kontos, Fanourios, Maniati, Maria, Costopoulos, Christos, Gitti, Zoe, Nicolaou, Stavroula, Petinaki, Efymia, Anagnostou, Spyridoula, Tselentis, Ioannis, Maniatis, Antonios N.
Format: Journal Article
Language:English
Published: Shannon Elsevier B.V 01-02-2004
Elsevier Science
Subjects:
Antitubercular Agents - pharmacology
Bactec MGIT 960 system
Biological and medical sciences
Drug Resistance, Multiple, Bacterial
Ethambutol - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Isoniazid - pharmacology
Microbial Sensitivity Tests - methods
Microbiology
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - growth & development
Mycobacterium tuberculosis - isolation & purification
Reagent Kits, Diagnostic
Rifampin - pharmacology
Sensitivity and Specificity
Streptomycin - pharmacology
Susceptibility testing
Tuberculosis - microbiology
Mycobacterium tuberculosis
Bactec MGIT 960 system
Susceptibility testing
Drug susceptibility test
Mycobacteriales
Multicenter study
Mycobacteriaceae
Bacteria
Actinomycetes
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Summary:The accuracy of the Bactec MGIT 960 system for susceptibility testing of 177 clinical isolates of Mycobacterium tuberculosis to first line drugs (isoniazid, rifampicin, ethambutol and streptomycin) was compared with the agar reference method. The sensitivity, the ability to detect resistance, of the MGIT system was 100%, while the specificity, the ability to detect susceptibility, ranged from 98.6% to 100% for all drugs tested.
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ISSN:0167-7012
1872-8359
DOI:10.1016/j.mimet.2003.10.015