Search Results - "Petibone, Dayton"

Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity by Petibone, Dayton M., Majeed, Waqar, Casciano, Daniel A.

“…Autophagy is a cellular process that facilitates nutrient turnover and removal of expended macromolecules and organelles to maintain homeostasis. The recycling…”
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Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine by Zhang, Yongbin, Petibone, Dayton, Xu, Yang, Mahmood, Meena, Karmakar, Alokita, Casciano, Dan, Ali, Syed, Biris, Alexandru S.

“…Abstract Carbon-based nanomaterials have attracted great interest in biomedical applications such as advanced imaging, tissue regeneration, and drug or gene…”
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Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment by Guo, Xiaoqing, Seo, Ji-Eun, Petibone, Dayton, Tryndyak, Volodymyr, Lee, Un Jung, Zhou, Tong, Robison, Timothy W., Mei, Nan

“…The micronucleus (MN) assay is a core test used to evaluate genotoxic potential of xenobiotics. The traditional in vitro MN assay is usually conducted in cells…”
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells by Seo, Ji-Eun, Guo, Xiaoqing, Petibone, Dayton M, Shelton, Sharon D, Chen, Ying, Li, Xilin, Tryndyak, Volodymyr, Smith-Roe, Stephanie L, Witt, Kristine L, Mei, Nan, Manjanatha, Mugimane G

“…Abstract Black cohosh extract (BCE) is marketed to women as an alternative to hormone replacement therapy for alleviating menopausal symptoms. Previous studies…”
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In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene by Dobrovolsky, Vasily N, Revollo, Javier, Petibone, Dayton M, Heflich, Robert H

“…The Pig-a assay is being developed as an in vivo gene mutation assay for regulatory safety assessments. The assay is based on detecting mutation in the…”
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Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats by Revollo, Javier, Pearce, Mason G, Petibone, Dayton M, Mittelstaedt, Roberta A, Dobrovolsky, Vasily N

“…The Pig-a assay is used for monitoring somatic cell mutation in laboratory animals and humans. The assay detects haematopoietic cells deficient in…”
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The role of surface chemistry in the cytotoxicity profile of graphene by Majeed, Waqar, Bourdo, Shawn, Petibone, Dayton M., Saini, Viney, Vang, Kieng Bao, Nima, Zeid A., Alghazali, Karrer M., Darrigues, Emilie, Ghosh, Anindya, Watanabe, Fumiya, Casciano, Daniel, Ali, Syed F., Biris, Alexandru S.

“…Graphene and its derivative, because of their unique physical, electrical and chemical properties, are an important class of nanomaterials being proposed as…”
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Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells by Revollo, Javier R., Pearce, Mason G., Dad, Azra, Petibone, Dayton M., Robison, Timothy W., Roberts, Daniel, Dobrovolsky, Vasily N.

“…We have established a flow cytometry‐based Pig‐a assay for rat bone marrow erythroid cells (BMEs). The BME Pig‐a assay uses a DNA‐specific stain and two…”
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Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research by Inselman, Amy, Liu, Fang, Wang, Cheng, Shi, Qiang, Pang, Li, Mattes, William, White, Matthew, Lyn-Cook, Beverly, Rosas-Hernandez, Hector, Cuevas, Elvis, Lantz, Susan, Imam, Syed, Ali, Syed, Petibone, Dayton M., Shemansky, Jennifer M., Xiong, Rui, Wang, Yiying, Tripathi, Priya, Cao, Xuefei, Heflich, Robert H., Slikker, William

“…For the past five years, Dr. Daniel Acosta has served as the Deputy Director of Research at the National Center for Toxicological Research (NCTR), a principle…”
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Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes by Dad, Azra, Revollo, Javier R., Petibone, Dayton M., Pearce, Mason G., Heflich, Robert H., Dobrovolsky, Vasily N.

“…The in vivo erythrocyte Pig‐a gene mutation assay measures the phenotypic loss of GPI‐anchored surface markers. Molecular analysis of the marker‐deficient…”
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In vivo genotoxicity of furan in F344 rats at cancer bioassay doses by Ding, Wei, Petibone, Dayton M., Latendresse, John R., Pearce, Mason G., Muskhelishvili, Levan, White, Gene A., Chang, Ching-Wei, Mittelstaedt, Roberta A., Shaddock, Joseph G., McDaniel, Lea P., Doerge, Daniel R., Morris, Suzanne M., Bishop, Michelle E., Manjanatha, Mugimane G., Aidoo, Anane, Heflich, Robert H.

“…Furan, a potent rodent liver carcinogen, is found in many cooked food items and thus represents a human cancer risk. Mechanisms for furan carcinogenicity were…”
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Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines by Revollo, Javier, Petibone, Dayton M., McKinzie, Page, Knox, Bridgett, Morris, Suzanne M., Ning, Baitang, Dobrovolsky, Vasily N.

“…•Predicted genes, SNPs and mutations in TK6 are similar to the human population.•TK6 (p53wt), WTK1(p53mut) and NH32(p53KO) transcriptomes have not diverged…”
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p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity by Petibone, Dayton M., Mustafa, Thikra, Bourdo, Shawn E., Lafont, Andersen, Ding, Wei, Karmakar, Alokita, Nima, Zeid A., Watanabe, Fumiya, Casciano, Daniel, Morris, Suzanne M., Dobrovolsky, Vasily N., Biris, Alexandru S.

“…Due to the distinctive physical, electrical, and chemical properties of graphene nanomaterials, numerous efforts pursuing graphene‐based biomedical and…”
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Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate by Mattison, Donald R, Plant, Tony M, Lin, Hui-Min, Chen, Hung-Chia, Chen, James J, Twaddle, Nathan C, Doerge, Daniel, Slikker, William Jr, Patton, Ralph E, Hotchkiss, Charlotte E, Callicott, Ralph J, Schrader, Steven M, Turner, Terry W, Kesner, James S, Vitiello, Benedetto, Petibone, Dayton M, Morris, Suzanne M

“…Juvenile male rhesus monkeys treated with methylphenidate hydrochloride (MPH) to evaluate genetic and behavioral toxicity were observed after 14 mo of…”
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Oligonucleotide immobilization using 10-(carbomethoxy)decyl-dimethylchlorosilane for mRNA isolation and cDNA synthesis on a microfluidic chip by Hughes-Chinkhota, Chantelle N., Banda, Malathi, Smolinski, Joseph M., Thomas, Robert A., Petibone, Dayton M., Tucker, James D., Auner, Gregory W.

“…Fabrication of microfluidic systems capable of extracting and isolating nucleic acids from biological samples and preparing them for downstream applications…”
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The genetic toxicity of methylphenidate: a review of the current literature by Morris, Suzanne M., Petibone, Dayton M., Lin, Wei-Jiun, Chen, James J., Vitiello, Benedetto, Witt, Kristine L., Mattison, Donald R.

“…ABSTRACT Attention deficit/hyperactivity disorder (ADHD), a common children's behavioral disorder, is characterized by inattention, hyperactivity and…”
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Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice by Petibone, Dayton M, Kulkarni, Rohan M, Chang, Ching-Wei, Chen, James J, Morris, Suzanne M

“…Our laboratory is conducting experiments designed to characterize the role of p53 in gene expression in the TSG-p53® mouse model. In the study reported here,…”
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Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder by Tucker, James D., Suter, Willi, Petibone, Dayton M., Thomas, Robert A., Bailey, Nicole L., Zhou, Yinong, Zhao, Yanxing, Muniz, Rafael, Kumar, Vinod

“…Methylphenidate (MPH, Ritalin ®), has been prescribed to treat attention deficit/hyperactivity disorder (ADHD) since its approval by the FDA over 50 years ago…”
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Retrospective Biodosimetry among United States Radiologic Technologists by Bhatti, Parveen, Preston, Dale L., Doody, Michele Morin, Hauptmann, Michael, Kampa, Diane, Alexander, Bruce H., Petibone, Dayton, Simon, Steven L., Weinstock, Robert M., Bouville, Andre, Yong, Lee C., Freedman, D. Michal, Mabuchi, Kiyohiko, Linet, Martha S., Edwards, Alan A., Tucker, James D., Sigurdson, Alice J.

“…Parveen, B., Preston, D. L., Doody, M. M., Hauptmann, M., Kampa, D., Alexander, B. H., Petibone, D., Simon, S. L., Weinstock, R. M., Bouville, A., Yong, L. C.,…”
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The genetic toxicology of methylphenidate hydrochloride in non-human primates by Morris, Suzanne M., Dobrovolsky, Vasily N., Shaddock, Joseph G., Mittelstaedt, Roberta A., Bishop, Michelle E., Manjanatha, Mugimane G., Shelton, Sharon D., Doerge, Daniel R., Twaddle, Nathan C., Chen, James J., Lin, Chien-Ju, Paule, Merle G., Slikker, William, Hotchkiss, Charlotte E., Petibone, Dayton, Tucker, James D., Mattison, Donald R.

“…The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a…”
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