Prognosis in malignant mesothelioma related to MIB 1 proliferation index and histological subtype

The aims of this study were to evaluate the use of the proliferation marker MIB 1 and histological subtype as indicators of prognosis in malignant mesothelioma. Sections from 41 cases of malignant mesothelioma were histologically subtyped on hematoxylin and eosin sections and stained immunohistochem...

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Bibliographic Details
Published in:	Human pathology Vol. 29; no. 3; pp. 246 - 251
Main Authors:	Beer, Trevor W, Buchanan, Rose, Matthews, Alan W, Stradling, Robin, Pullinger, Neil, Pethybridge, Roger J
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-03-1998 Elsevier
Subjects:	Antibodies, Monoclonal - biosynthesis Antigens, Neoplasm - biosynthesis Antigens, Nuclear Biological and medical sciences Biomarkers, Tumor Cell Count Cell Division Humans Immunohistochemistry Ki-67 Antigen - metabolism Malignant mesothelioma Medical sciences Mesothelioma - metabolism Mesothelioma - mortality Mesothelioma - pathology MIB 1 Mitotic Index Nuclear Proteins - metabolism Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - mortality Peritoneal Neoplasms - pathology Pleural Neoplasms - metabolism Pleural Neoplasms - mortality Pleural Neoplasms - pathology Pneumology Prognosis Proliferation Survival Analysis Tumors of the respiratory system and mediastinum MIB 1 Malignant mesothelioma Prognosis PCNA Proliferation UK Human Immunohistochemistry Cell proliferation Pathology Respiratory disease Histological type Pleural disease Malignant tumor Index (documentation) Pleura
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Summary:	The aims of this study were to evaluate the use of the proliferation marker MIB 1 and histological subtype as indicators of prognosis in malignant mesothelioma. Sections from 41 cases of malignant mesothelioma were histologically subtyped on hematoxylin and eosin sections and stained immunohistochemically for the proliferation marker MIB 1. A proliferation index was derived and the results compared with patient survival data. A statistically significant difference was found between the survival of patients having a low and high MIB 1 index ( P < .001). Patients with tumors having a low MIB 1 index lived significantly longer than those with a high MIB 1 index. Patients with the spindle cell histological subtype of malignant mesothelioma had significantly shorter survival times than those with the epithelioid or mixed tumors ( P < .01). The MIB 1 proliferation index and histological tumor subtype are useful markers of prognosis in malignant mesothelioma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0046-8177 1532-8392
DOI:	10.1016/S0046-8177(98)90043-0