Search Results - "Petes, Thomas D"

Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements by Qi, Lei, Sui, Yang, Tang, Xing-Xing, McGinty, Ryan J, Liang, Xiao-Zhuan, Dominska, Margaret, Zhang, Ke, Mirkin, Sergei M, Zheng, Dao-Qiong, Petes, Thomas D

“…Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of…”
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High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV by St Charles, Jordan, Petes, Thomas D

“…Although homologous recombination is an important pathway for the repair of double-stranded DNA breaks in mitotically dividing eukaryotic cells, these events…”
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Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae by Yin, Yi, Petes, Thomas D

“…In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs)…”
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Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast by Zhang, Ke, Zheng, Dao-Qiong, Sui, Yang, Qi, Lei, Petes, Thomas D

“…Abstract Oxidative DNA damage is a threat to genome stability. Using a genetic system in yeast that allows detection of mitotic recombination, we found that…”
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Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity by O'Connell, Karen, Jinks-Robertson, Sue, Petes, Thomas D

“…Two types of RNA:DNA associations can lead to genome instability: the formation of R-loops during transcription and the incorporation of ribonucleotide…”
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Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae by Song, Wei, Dominska, Margaret, Greenwell, Patricia W, Petes, Thomas D

“…In mammalian cells, perturbations in DNA replication result in chromosome breaks in regions termed “fragile sites.” Using DNA microarrays, we mapped…”
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Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides by Sui, Yang, Epstein, Anastasiya, Dominska, Margaret, Zheng, Dao-Qiong, Petes, Thomas D, Klein, Hannah L

“…Abstract Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently…”
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Chromosome rearrangements via template switching between diverged repeated sequences by Anand, Ranjith P, Tsaponina, Olga, Greenwell, Patricia W, Lee, Cheng-Sheng, Du, Wei, Petes, Thomas D, Haber, James E

“…Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy…”
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Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification by Deng, Sarah K., Yin, Yi, Petes, Thomas D., Symington, Lorraine S.

“…Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate palindromic gene amplification, a common feature of cancer cells. Here, we…”
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Double-Strand Breaks Associated with Repetitive DNA Can Reshape the Genome by Argueso, Juan Lucas, Westmoreland, James, Mieczkowski, Piotr A., Gawel, Malgorzata, Petes, Thomas D., Resnick, Michael A.

“…Ionizing radiation is an established source of chromosome aberrations (CAs). Although double-strand breaks (DSBs) are implicated in radiation-induced and other…”
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Meiotic recombination hot spots and cold spots by Petes, Thomas D

“…Meiotic recombination events are distributed unevenly throughout eukaryotic genomes. This inhomogeneity leads to distortions of genetic maps that can hinder…”
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Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p by Yin, Yi, Petes, Thomas D

“…DNA lesions caused by UV radiation are highly recombinogenic. In wild-type cells, the recombinogenic effect of UV partially reflects the processing of…”
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Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair by McGinty, Ryan J, Rubinstein, Rachel G, Neil, Alexander J, Dominska, Margaret, Kiktev, Denis, Petes, Thomas D, Mirkin, Sergei M

“…Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans…”
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The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ by Kiktev, Denis A, Dominska, Margaret, Zhang, Tony, Dahl, Joseph, Stepchenkova, Elena I, Mieczkowski, Piotr, Burgers, Peter M, Lujan, Scott, Burkholder, Adam, Kunkel, Thomas A, Petes, Thomas D

“…Abstract Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic…”
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Genome rearrangements caused by interstitial telomeric sequences in yeast by Aksenova, Anna Y., Greenwell, Patricia W., Dominska, Margaret, Shishkin, Alexander A., Kim, Jane C., Petes, Thomas D., Mirkin, Sergei M.

“…Interstitial telomeric sequences (ITSs) are present in many eukaryotic genomes and are linked to genome instabilities and disease in humans. The mechanisms…”
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Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae by Zhao, Ying, Dominska, Margaret, Petrova, Aleksandra, Bagshaw, Halle, Kokoska, Robert J, Petes, Thomas D

“…In the yeast , the genes encoding the metallothionein protein Cup1 are located in a tandem array on chromosome VIII. Using a diploid strain that is…”
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A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiae by Lee, Phoebe S, Greenwell, Patricia W, Dominska, Margaret, Gawel, Malgorzata, Hamilton, Monica, Petes, Thomas D

“…Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with…”
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High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast by Yin, Yi, Dominska, Margaret, Yim, Eunice, Petes, Thomas D

“…In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a…”
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Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production by Argueso, Juan Lucas, Carazzolle, Marcelo F, Mieczkowski, Piotr A, Duarte, Fabiana M, Netto, Osmar V C, Missawa, Silvia K, Galzerani, Felipe, Costa, Gustavo G L, Vidal, Ramon O, Noronha, Melline F, Dominska, Margaret, Andrietta, Maria G S, Andrietta, Sílvio R, Cunha, Anderson F, Gomes, Luiz H, Tavares, Flavio C A, Alcarde, André R, Dietrich, Fred S, McCusker, John H, Petes, Thomas D, Pereira, Gonçalo A G

“…Bioethanol is a biofuel produced mainly from the fermentation of carbohydrates derived from agricultural feedstocks by the yeast Saccharomyces cerevisiae. One…”
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High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events by St Charles, Jordan, Hazkani-Covo, Einat, Yin, Yi, Andersen, Sabrina L, Dietrich, Fred S, Greenwell, Patricia W, Malc, Ewa, Mieczkowski, Piotr, Petes, Thomas D

“…In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of…”
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