Search Results - "Peterson, Randall T"

Use of Zebrafish in Drug Discovery Toxicology by Cassar, Steven, Adatto, Isaac, Freeman, Jennifer L, Gamse, Joshua T, Iturria, Iñaki, Lawrence, Christian, Muriana, Arantza, Peterson, Randall T, Van Cruchten, Steven, Zon, Leonard I

“…Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to…”
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The zebrafish subcortical social brain as a model for studying social behavior disorders by Geng, Yijie, Peterson, Randall T

“…Social behaviors are essential for the survival and reproduction of social species. Many, if not most, neuropsychiatric disorders in humans are either…”
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Bioorthogonal Removal of 3‑Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo by Tu, Julian, Xu, Minghao, Parvez, Saba, Peterson, Randall T, Franzini, Raphael M

“…Dissociative bioorthogonal reactions allow for chemically controlling the release of bioactive agents and reporter probes. Here we describe 3-isocyanopropyl…”
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The zebrafish as a tool to identify novel therapies for human cardiovascular disease by Asnani, Aarti, Peterson, Randall T

“…Over the past decade, the zebrafish has become an increasingly popular animal model for the study of human cardiovascular disease. Because zebrafish embryos…”
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Heritable and precise zebrafish genome editing using a CRISPR-Cas system by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Kaini, Prakriti, Sander, Jeffry D, Joung, J Keith, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…We have previously reported a simple and customizable CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided Cas9 nuclease (RGN) system…”
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Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions by Peng, Jia, Li, Qinglei, Wigglesworth, Karen, Rangarajan, Adithya, Kattamuri, Chandramohan, Peterson, Randall T, Eppig, John J, Thompson, Thomas B, Matzuk, Martin M

“…The TGF-β superfamily is the largest family of secreted proteins in mammals, and members of the TGF-β family are involved in most developmental and…”
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Systematic Approaches to Toxicology in the Zebrafish by PETERSON, Randall T, MACRAE, Calum A

“…As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and…”
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Large-scale F0 CRISPR screens in vivo using MIC-Drop by Parvez, Saba, Brandt, Zachary J., Peterson, Randall T.

“…The zebrafish is a powerful model system for studying animal development, for modeling genetic diseases, and for large-scale in vivo functional genetics…”
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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation by Rihel, Jason, Prober, David A, Arvanites, Anthony, Lam, Kelvin, Zimmerman, Steven, Jang, Sumin, Haggarty, Stephen J, Kokel, David, Rubin, Lee L, Peterson, Randall T, Schier, Alexander F

“…A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the…”
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MIC-Drop: A platform for large-scale in vivo CRISPR screens by Parvez, Saba, Herdman, Chelsea, Beerens, Manu, Chakraborti, Korak, Harmer, Zachary P, Yeh, Jing-Ruey J, MacRae, Calum A, Yost, H Joseph, Peterson, Randall T

“…CRISPR-Cas9 can be scaled up for large-scale screens in cultured cells, but CRISPR screens in animals have been challenging because generating, validating, and…”
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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs by Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y, Tsai, Shengdar Q, Patel, Samir, Khayter, Cyd, Joung, J Keith, Sander, Jeffry D, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…Transcription activator-like effector nucleases (TALENs) are powerful new research tools that enable targeted gene disruption in a wide variety of model…”
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Rapid behavior-based identification of neuroactive small molecules in the zebrafish by Kokel, David, Peterson, Randall T, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J, Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A, Haggarty, Stephen J, MacRae, Calum A, Shoichet, Brian

“…Despite the need for new psychoactive drugs, there are few robust approaches for discovering novel neuroactive molecules. Development of a behavior-based…”
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism by Yu, Paul B, Hoyng, Stefan A, Bloch, Kenneth D, Lin, Herbert Y, Hong, Charles C, Deng, Donna Y, Peterson, Randall T, Babitt, Jodie L, Sachidanandan, Chetana

“…Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. Here we describe the…”
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BMP type I receptor inhibition reduces heterotopic ossification by Yu, Paul B, Deng, Donna Y, Lai, Carol S, Hong, Charles C, Cuny, Gregory D, Bouxsein, Mary L, Hong, Deborah W, McManus, Patrick M, Katagiri, Takenobu, Sachidanandan, Chetana, Kamiya, Nobuhiro, Fukuda, Tomokazu, Mishina, Yuji, Peterson, Randall T, Bloch, Kenneth D

“…Ectopic ossification often involves the transformation of soft tissue into bone. In this new study, Paul Yu et al. show that inflammation is a key step in…”
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Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment by van Ham, Tjakko J., Kokel, David, Peterson, Randall T.

“…Apoptotic cell death is essential for development and tissue homeostasis [1, 2]. Failure to clear apoptotic cells can ultimately cause inflammation and…”
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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA) by Joung, J Keith, Sander, Jeffry D, Dahlborg, Elizabeth J, Goodwin, Mathew J, Cade, Lindsay, Zhang, Feng, Cifuentes, Daniel, Curtin, Shaun J, Blackburn, Jessica S, Thibodeau-Beganny, Stacey, Qi, Yiping, Pierick, Christopher J, Hoffman, Ellen, Maeder, Morgan L, Khayter, Cyd, Reyon, Deepak, Dobbs, Drena, Langenau, David M, Stupar, Robert M, Giraldez, Antonio J, Voytas, Daniel F, Peterson, Randall T, Yeh, Jing-Ruey J

“…Engineered zinc-finger nucleases (ZFNs) enable targeted genome modification. Here we describe context-dependent assembly (CoDA), a platform for engineering…”
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An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency by Hope, Kevin A, Berman, Alexys R, Peterson, Randall T, Chow, Clement Y

“…NGLY1 deficiency, a rare disease with no effective treatment, is caused by autosomal recessive, loss-of-function mutations in the N-glycanase 1 (NGLY1) gene…”
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Zebrafish Models of Cerebrovascular Disease by Walcott, Brian P, Peterson, Randall T

“…Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and…”
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Chemical biology and the limits of reductionism by Peterson, Randall T

“…Chemical biology and systems biology have grown and evolved in parallel during the past decade, but the mindsets of the two disciplines remain quite different…”
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Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation by McCarroll, Matthew N., Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K., Tomita, Susumu, Peterson, Randall T., Keiser, Michael J., Kokel, David

“…Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical…”
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