Search Results - "Peterson, Leif E"

Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension by Phillips, Robert A., Xu, Jiaqiong, Peterson, Leif E., Arnold, Ryan M., Diamond, Joseph A., Schussheim, Adam E.

“…The lower rate of primary outcome events in the intensive treatment group in SPRINT (Systolic Pressure Intervention Trial) was associated with increased…”
Get full text

Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs by Perez, Katherine K, Olsen, Randall J, Musick, William L, Cernoch, Patricia L, Davis, James R, Land, Geoffrey A, Peterson, Leif E, Musser, James M

“…Early diagnosis of gram-negative bloodstream infections, prompt identification of the infecting organism, and appropriate antibiotic therapy improve patient…”
Get full text

The Coronary Artery Calcium Score and Stress Myocardial Perfusion Imaging Provide Independent and Complementary Prediction of Cardiac Risk by Chang, Su Min, MD, Nabi, Faisal, MD, Xu, Jiaqiong, PhD, Peterson, Leif E., PhD, Achari, Arup, MD, Pratt, Craig M., MD, Mahmarian, John J., MD

“…Objectives This study sought to examine the relationship between coronary artery calcium score (CACS) and single-photon emission computed tomography (SPECT)…”
Get full text

Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors by Peterson, Leif E

“…Natural and synthetic small molecules from the NCI Developmental Therapeutics Program (DTP) were employed in molecular dynamics-based docking with DNA repair…”
Get full text

Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer by HODGSON, Myles C, SHAO, Long-Jiang, FROLOV, Anna, RILE LI, PETERSON, Leif E, AYALA, Gustavo, ITTMANN, Michael M, WEIGEL, Nancy L, AGOULNIK, Irina U

“…Patients with metastatic prostate cancer who undergo androgen-ablation therapy invariably relapse and develop incurable castration-resistant disease…”
Get full text

Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes by Coleman, Matthew A, Sasi, Sharath P, Onufrak, Jillian, Natarajan, Mohan, Manickam, Krishnan, Schwab, John, Muralidharan, Sujatha, Peterson, Leif E, Alekseyev, Yuriy O, Yan, Xinhua, Goukassian, David A

“…There are 160,000 cancer patients worldwide treated with particle radiotherapy (RT). With the advent of proton, and high (H) charge (Z) and energy (E) HZE…”
Get more information

Inducible FGFR-1 Activation Leads to Irreversible Prostate Adenocarcinoma and an Epithelial-to-Mesenchymal Transition by Acevedo, Victor D., Gangula, Rama D., Freeman, Kevin W., Li, Rile, Zhang, Youngyou, Wang, Fen, Ayala, Gustavo E., Peterson, Leif E., Ittmann, Michael, Spencer, David M.

“…Fibroblast Growth Factor Receptor-1 (FGFR1) is commonly overexpressed in advanced prostate cancer (PCa). To investigate causality, we utilized an inducible…”
Get full text

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation by Yin, Zheng, Deng, Tuo, Peterson, Leif E., Yu, Richeng, Lin, Jianxin, Hamilton, Dale J., Reardon, Patrick R., Sherman, Vadim, Winnier, Glenn E., Zhan, Ming, Lyon, Christopher J., Wong, Stephen T.C., Hsueh, Willa A.

“…•NLRP3 inflammasome expression increases in adipocytes but not SVF during obesity.•After adjusting for BMI, inflammasome genes correlate only with adipocyte…”
Get full text

Shear-wave elastography of the ulnar collateral ligament of the elbow in healthy volunteers: a pilot study by Gupta, Nakul, Labis, John S., Harris, Joshua, Trakhtenbroit, Michael A., Peterson, Leif E., Jack, Robert A., McCulloch, Patrick C.

“…Objective To estimate the intra-observer repeatability of shear wave elastography in the UCL of the elbow, and to compare shear wave velocities between…”
Get full text

Mechanical unloading promotes myocardial energy recovery in human heart failure by Gupte, Anisha A, Hamilton, Dale J, Cordero-Reyes, Andrea M, Youker, Keith A, Yin, Zheng, Estep, Jerry D, Stevens, Robert D, Wenner, Brett, Ilkayeva, Olga, Loebe, Matthias, Peterson, Leif E, Lyon, Christopher J, Wong, Stephen T C, Newgard, Christopher B, Torre-Amione, Guillermo, Taegtmeyer, Heinrich, Hsueh, Willa A

“…Impaired bioenergetics is a prominent feature of the failing heart, but the underlying metabolic perturbations are poorly understood. We compared metabolomic,…”
Get full text

Characterization of BRCA1 and BRCA2 Mutations in a Large United States Sample by SINING CHEN, IVERSEN, Edwin S, CORIO, Camille, LEONDARIDIS, Leoni, TOMLINSON, Gail, DUTSON, Debra, KERBER, Rich, AMOS, Christopher I, STRONG, Louise C, BERRY, Donald A, EUHUS, David M, PARMIGIANI, Giovanni, FRIEBEL, Tara, FINKELSTEIN, Dianne, WEBER, Barbara L, EISEN, Andrea, PETERSON, Leif E, SCHILDKRAUT, Joellen M, ISAACS, Claudine, PESHKIN, Beth N

“…An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is essential to the identification and clinical management of families at high risk of…”
Get full text

Coronary Artery Calcium Scoring in the Emergency Department: Identifying Which Patients With Chest Pain Can Be Safely Discharged Home by Nabi, Faisal, MD, Chang, Su Min, MD, Pratt, Craig M., MD, Paranilam, Jaya, PhD, Peterson, Leif E., PhD, Frias, Maria E, Mahmarian, John J., MD

“…Study objective Coronary artery calcium scoring (CACS) is a simple and readily available test for identifying coronary artery disease. Our objective is to…”
Get full text

Hippocampal Transcriptome Changes After Subarachnoid Hemorrhage in Mice by Regnier-Golanov, Angelique S, Dündar, Friederike, Zumbo, Paul, Betel, Doron, Hernandez, Magda S, Peterson, Leif E, Lo, Eng H, Golanov, Eugene V, Britz, Gavin W

“…After subarachnoid hemorrhage (SAH), up to 95% of surviving patients suffer from post-SAH syndrome, which includes cognitive deficits with impaired memory,…”
Get full text

Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom by Ferrone, Kristine L., Willis, Charles E., Guan, Fada, Ma, Jingfei, Peterson, Leif E., Kry, Stephen F.

“…Background Reliable estimates of radiation dose to bone marrow are critical to understanding the risk of radiation‐induced cancers. Although the medical…”
Get full text

Progression inference for somatic mutations in cancer by Peterson, Leif E., Kovyrshina, Tatiana

“…Computational methods were employed to determine progression inference of genomic alterations in commonly occurring cancers. Using cross-sectional TCGA data,…”
Get full text

NASA Study of Cataract in Astronauts (NASCA). Report 1: Cross-Sectional Study of the Relationship of Exposure to Space Radiation and Risk of Lens Opacity by Chylack, Leo T., Peterson, Leif E., Feiveson, Alan H., Wear, Mary L., Manuel, F. Keith, Tung, William H., Hardy, Dale S., Marak, Lisa J., Cucinotta, Francis A.

“…Chylack, L. T., Jr., Peterson. L. E., Feiveson, A. H., Wear, M. L., Manuel, F. K., Tung, W. H., Hardy, D. S., Marak, L. J. and Cucinotta, F. A. NASA Study of…”
Get full text

Differential Roles of Cardiomyocyte and Macrophage Peroxisome Proliferator–Activated Receptor γ in Cardiac Fibrosis by Caglayan, Evren, Stauber, Bradley, Collins, Alan R, Lyon, Christopher J, Yin, Fen, Liu, Joey, Rosenkranz, Stephan, Erdmann, Erland, Peterson, Leif E, Ross, Robert S, Tangirala, Rajendra K, Hsueh, Willa A

“…Differential Roles of Cardiomyocyte and Macrophage Peroxisome Proliferator–Activated Receptor γ in Cardiac Fibrosis Evren Caglayan 1 2 , Bradley Stauber 1 ,…”
Get full text

Adjustment of lifetime risks of space radiation-induced cancer by the healthy worker effect and cancer misclassification by Peterson, Leif E., Kovyrshina, Tatiana

“…Background. The healthy worker effect (HWE) is a source of bias in occupational studies of mortality among workers caused by use of comparative disease rates…”
Get full text

Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial by Valderrábano, Miguel, Peterson, Leif E, Swarup, Vijay, Schurmann, Paul A, Makkar, Akash, Doshi, Rahul N, DeLurgio, David, Athill, Charles A, Ellenbogen, Kenneth A, Natale, Andrea, Koneru, Jayanthi, Dave, Amish S, Giorgberidze, Irakli, Afshar, Hamid, Guthrie, Michelle L, Bunge, Raquel, Morillo, Carlos A, Kleiman, Neal S

“…IMPORTANCE: Catheter ablation of persistent atrial fibrillation (AF) has limited success. Procedural strategies beyond pulmonary vein isolation have failed to…”
Get full text

Evaluating biomarkers to model cancer risk post cosmic ray exposure by Sridharan, Deepa M., Asaithamby, Aroumougame, Blattnig, Steve R., Costes, Sylvain V., Doetsch, Paul W., Dynan, William S., Hahnfeldt, Philip, Hlatky, Lynn, Kidane, Yared, Kronenberg, Amy, Naidu, Mamta D., Peterson, Leif E., Plante, Ianik, Ponomarev, Artem L., Saha, Janapriya, Snijders, Antoine M., Srinivasan, Kalayarasan, Tang, Jonathan, Werner, Erica, Pluth, Janice M.

“…Robust predictive models are essential to manage the risk of radiation-induced carcinogenesis. Chronic exposure to cosmic rays in the context of the complex…”
Get full text