Search Results - "Peterson, Kevin L."

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2 by French, Andrea J, Natesampillai, Sekar, Krogman, Ashton, Correia, Cristina, Peterson, Kevin L, Alto, Alecia, Chandrasekar, Aswath P, Misra, Anisha, Li, Ying, Kaufmann, Scott H, Badley, Andrew D, Cummins, Nathan W

“…Eradication of HIV-1 by the "kick and kill" strategy requires reactivation of latent virus to cause death of infected cells by either HIV-induced or…”
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A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia by Murthy, Guru Subramanian Guru, Saliba, Antoine N, Szabo, Aniko, Harrington, Alexandra, Abedin, Sameem, Carlson, Karen, Michaelis, Laura, Runaas, Lyndsey, Baim, Arielle, Hinman, Alex, Maldonado-Schmidt, Sonia, Venkatachalam, Annapoorna, Flatten, Karen S, Peterson, Kevin L, Schneider, Paula A, Litzow, Mark, Kaufmann, Scott H, Atallah, Ehab

“…Azacitidine/venetoclax is an active regimen in patients with newly diagnosed acute myeloid leukemia (AML). However, primary or secondary resistance to…”
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Immunodetection of human topoisomerase I-DNA covalent complexes by Patel, Anand G, Flatten, Karen S, Peterson, Kevin L, Beito, Thomas G, Schneider, Paula A, Perkins, Angela L, Harki, Daniel A, Kaufmann, Scott H

“…A number of established and investigational anticancer drugs slow the religation step of DNA topoisomerase I (topo I). These agents induce cytotoxicity by…”
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Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells by Dai, Haiming, Ding, Husheng, Meng, X Wei, Peterson, Kevin L, Schneider, Paula A, Karp, Judith E, Kaufmann, Scott H

“…Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood. Current models emphasize the…”
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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid…”
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Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies by Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.

“…The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which…”
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CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo by Chaudhuri, Leena, Vincelette, Nicole D, Koh, Brian D, Naylor, Ryan M, Flatten, Karen S, Peterson, Kevin L, McNally, Amanda, Gojo, Ivana, Karp, Judith E, Mesa, Ruben A, Sproat, Lisa O, Bogenberger, James M, Kaufmann, Scott H, Tibes, Raoul

“…Novel combinations targeting new molecular vulnerabilities are needed to improve the outcome of patients with acute myeloid leukemia. We recently identified…”
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Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway by HUNTOON, Catherine J, NYE, Monica D, LIYI GENG, PETERSON, Kevin L, FLATTEN, Karen S, HALUSKA, Paul, KAUFMANN, Scott H, KARNITZ, Larry M

“…Heat shock protein 90 (HSP90), which regulates the functions of multiple oncogenic signaling pathways, has emerged as a novel anticancer therapeutic target,…”
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A phase 2 and pharmacological study of sapanisertib in patients with relapsed and/or refractory acute lymphoblastic leukemia by Al‐Kali, Aref, Aldoss, Ibrahim, Atherton, Pamela J., Strand, Carrie A., Shah, Bijal, Webster, Jonathan, Bhatnagar, Bhavana, Flatten, Karen S., Peterson, Kevin L., Schneider, Paula A., Buhrow, Sarah A., Kong, Jianping, Reid, Joel M., Adjei, Alex A., Kaufmann, Scott H.

“…Background Despite recent approval of several new agents, relapsed acute lymphoblastic leukemia (ALL) remains challenging to treat. Sapanisertib…”
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Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer by Jayaraman, Swaathi, Wu, Xinyan, Kalari, Krishna R., Tang, Xiaojia, Kuffel, Mary J., Bruinsma, Elizabeth S., Jalali, Shahrzad, Peterson, Kevin L., Correia, Cristina, Kudgus, Rachel A., Kaufmann, Scott H., Renuse, Santosh, Ingle, James N., Reid, Joel M., Ames, Matthew M., Fields, Alan P., Schellenberg, Matthew J., Hawse, John R., Pandey, Akhilesh, Goetz, Matthew P.

“…Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II…”
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Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation by Ding, Husheng, Hackbarth, Jennifer, Schneider, Paula A., Peterson, Kevin L., Meng, X. Wei, Dai, Haiming, Witzig, Thomas E., Kaufmann, Scott H.

“…The mechanism of cytotoxicity of farnesyltransferase inhibitors is incompletely understood and seems to vary depending on the cell type. To identify potential…”
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Comparison of the Phosphorus and Mineral Concentrations in Bran and Abraded Kernel Fractions of a Normal Barley (Hordeum vulgare) Cultivar versus Four Low Phytic Acid Isolines by Liu, Peterson, Kevin L, Raboy, Victor

“…Phytic acid consists of 65−80% of the total phosphorus (P) in cereal grains. Its salts are concentrated in the germ and aleurone layers, which are typically…”
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Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia by KAUFMANN, Scott H, KARP, Judith E, MAURER, Matthew J, DOUGLAS SMITH, B, GREER, Jacqueline, YUHONG CHEN, REID, Joel M, PERCY IVY, S, AMES, Matthew M, ADJEI, Alex A, ERLICHMAN, Charles, KARNITZ, Larry M, LITZOW, Mark R, MESA, Ruben A, HOGAN, William, STEENSMA, David P, FLATTEN, Karen S, LOEGERING, David A, SCHNEIDER, Paula A, PETERSON, Kevin L

“…In preclinical studies the heat shock protein 90 (Hsp90) inhibitor tanespimycin induced down-regulation of checkpoint kinase 1 (Chk1) and other client proteins…”
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Absorption of calcium from tortilla meals prepared from low-phytate maize by Hambidge, K.M, Krebs, N.F, Westcott, J.L, Sian, L, Miller, L.V, Peterson, K.L, Raboy, V

“…Background: Calcium fortification of maize has been achieved for millennia in Central America by the process of nixtamalization. Bioavailability of calcium is,…”
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Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis by Maskey, Reeja S, Flatten, Karen S, Sieben, Cynthia J, Peterson, Kevin L, Baker, Darren J, Nam, Hyun-Ja, Kim, Myoung Shin, Smyrk, Thomas C, Kojima, Yusuke, Machida, Yuka, Santiago, Annyoceli, van Deursen, Jan M, Kaufmann, Scott H, Machida, Yuichi J

“…Germline mutations in SPRTN cause Ruijs-Aalfs syndrome (RJALS), a disorder characterized by genome instability, progeria and early onset hepatocellular…”
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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C by Dai, Haiming, Peterson, Kevin L., Flatten, Karen S., Meng, X. Wei, Venkatachalam, Annapoorna, Correia, Cristina, Ramirez-Alvarado, Marina, Pang, Yuan-Ping, Kaufmann, Scott H.

“…How BAK and BAX induce mitochondrial outer membrane (MOM) permeabilization (MOMP) during apoptosis is incompletely understood. Here we have used molecular…”
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Correction: High cell surface death receptor expression determines type I versus type II signaling by Meng, Xue Wei, Peterson, Kevin L., Dai, Haiming, Schneider, Paula, Lee, Sun-Hee, Zhang, Jin-San, Koenig, Alexander, Bronk, Steve, Billadeau, Daniel D., Gores, Gregory J., Kaufmann, Scott H.

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Mitotic Phosphorylation Stimulates DNA Relaxation Activity of Human Topoisomerase I by Hackbarth, Jennifer S., Galvez-Peralta, Marina, Dai, Nga T., Loegering, David A., Peterson, Kevin L., Meng, Xue W., Karnitz, Larry M., Kaufmann, Scott H.

“…Human DNA topoisomerase I (topo I) is an essential mammalian enzyme that regulates DNA supercoiling during transcription and replication. In addition, topo I…”
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Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells by Ding, Husheng, McDonald, Jennifer S, Yun, Seongseok, Schneider, Paula A, Peterson, Kevin L, Flatten, Karen S, Loegering, David A, Oberg, Ann L, Riska, Shaun M, Huang, Shengbing, Sinicrope, Frank A, Adjei, Alex A, Karp, Judith E, Meng, X Wei, Kaufmann, Scott H

“…Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism…”
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AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death by Jia, Jia, Ji, Wenbo, Saliba, Antoine N., Csizmar, Clifford M., Ye, Kaiqin, Hu, Lei, Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Venkatachalam, Annapoorna, Patnaik, Mrinal M., Webster, Jonathan A., Smith, B. Douglas, Ghiaur, Gabriel, Wu, Xinyan, Zhong, Jun, Pandey, Akhilesh, Flatten, Karen S., Deng, Qingmei, Wang, Hongzhi, Kaufmann, Scott H., Dai, Haiming

“…BH3 mimetics, including the BCL2/BCLX L /BCLw inhibitor navitoclax and MCL1 inhibitors S64315 and tapotoclax, have undergone clinical testing for a variety of…”
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