Search Results - "Peterson, Janine H."

Bacterial Outer Membrane Proteins Are Targeted to the Bam Complex by Two Parallel Mechanisms by Wang, Xu, Peterson, Janine H, Bernstein, Harris D

“…Membrane proteins that are integrated into the outer membrane of Gram-negative bacteria typically contain a unique "β barrel" structure that serves as a…”
Get full text

Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly by Peterson, Janine H., Doyle, Matthew Thomas, Bernstein, Harris D.

“…Several antibacterial compounds have recently been discovered that potentially inhibit the activity of BamA, an essential subunit of a heterooligomer (the…”
Get full text

Sequential and spatially restricted interactions of assembly factors with an autotransporter β domain by Ieva, Raffaele, Tian, Pu, Peterson, Janine H., Bernstein, Harris D.

“…Autotransporters are bacterial virulence factors that consist of an N-terminal extracellular (“passenger”) domain and a C-terminal β barrel domain (“β domain”)…”
Get full text

Mechanistic link between β barrel assembly and the initiation of autotransporter secretion by Pavlova, Olga, Peterson, Janine H, Ieva, Raffaele, Bernstein, Harris D

“…Autotransporters are bacterial virulence factors that contain an N-terminal extracellular (“passenger”) domain and a C-terminal β barrel (“β”) domain that…”
Get full text

Folding of a bacterial integral outer membrane protein is initiated in the periplasm by Sikdar, Rakesh, Peterson, Janine H., Anderson, D. Eric, Bernstein, Harris D.

“…The Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid…”
Get full text

Reconstitution of bacterial autotransporter assembly using purified components by Roman-Hernandez, Giselle, Peterson, Janine H, Bernstein, Harris D

“…Autotransporters are a superfamily of bacterial virulence factors consisting of an N-terminal extracellular ('passenger') domain and a C-terminal β barrel…”
Get full text

Identification of a novel post‐insertion step in the assembly of a bacterial outer membrane protein by Peterson, Janine H., Hussain, Sunyia, Bernstein, Harris D.

“…Summary Although the barrel assembly machinery (Bam) complex has been shown to facilitate the insertion of β barrel proteins into the bacterial outer membrane…”
Get full text

Bam complex-mediated assembly of bacterial outer membrane proteins synthesized in an in vitro translation system by Hussain, Sunyia, Peterson, Janine H., Bernstein, Harris D.

“…Bacterial outer membrane proteins (OMPs) contain a unique “β barrel” segment that is inserted into the membrane by the b arrel a ssembly m achinery (Bam)…”
Get full text

Reconstitution of Bam Complex-Mediated Assembly of a Trimeric Porin into Proteoliposomes by Hussain, Sunyia, Peterson, Janine H, Bernstein, Harris D

“…Many integral membrane proteins form oligomeric complexes, but the assembly of these structures is poorly understood. Here, we show that the assembly of OmpC,…”
Get full text

Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment by Peterson, Janine H., Tian, Pu, Ieva, Raffaele, Dautin, Nathalie, Bernstein, Harris D.

“…Autotransporters are bacterial virulence factors consisting of an N-terminal "passenger domain" that is secreted in a C- to-N-terminal direction and a…”
Get full text

An Unusual Signal Peptide Facilitates Late Steps in the Biogenesis of a Bacterial Autotransporter by Szabady, Rose L., Peterson, Janine H., Skillman, Kristen M., Bernstein, Harris D., Schekman, Randy

“…Bacterial autotransporters are proteins that use a C-terminal porin-like domain to facilitate the transport of an upstream "passenger domain" across the outer…”
Get full text

Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter by Skillman, Kristen M., Barnard, Travis J., Peterson, Janine H., Ghirlando, Rodolfo, Bernstein, Harris D.

“…Summary Bacterial autotransporters are proteins that contain a small C‐terminal ‘β domain’ that facilitates translocation of a large N‐terminal ‘passenger…”
Get full text

An Unusual Signal Peptide Extension Inhibits the Binding of Bacterial Presecretory Proteins to the Signal Recognition Particle, Trigger Factor, and the SecYEG Complex by Peterson, Janine H., Szabady, Rose L., Bernstein, Harris D.

“…Considerable evidence indicates that the Escherichia coli signal recognition particle (SRP) selectively targets proteins that contain highly hydrophobic signal…”
Get full text

Basic Amino Acids in a Distinct Subset of Signal Peptides Promote Interaction with the Signal Recognition Particle by Peterson, Janine H., Woolhead, Cheryl A., Bernstein, Harris D.

“…Previous studies have demonstrated that signal peptides bind to the signal recognition particle (SRP) primarily via hydrophobic interactions with the 54-kDa…”
Get full text

Selective pressure for rapid membrane integration constrains the sequence of bacterial outer membrane proteins by Peterson, Janine H., Plummer, Ashlee M., Fleming, Karen G., Bernstein, Harris D.

“…Summary Almost all bacterial outer membrane proteins (OMPs) contain a β barrel domain that serves as a membrane anchor, but the assembly and quality control of…”
Get full text

conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding by Peterson, Janine H, Woolhead, Cheryl A, Bernstein, Harris D

“…In this report, we describe insights into the function of the ribosome tunnel that were obtained through an analysis of an unusual 25 residue N-terminal motif…”
Get full text

Molecular Basis for the Activation of a Catalytic Asparagine Residue in a Self-Cleaving Bacterial Autotransporter by Barnard, Travis J., Gumbart, James, Peterson, Janine H., Noinaj, Nicholas, Easley, Nicole C., Dautin, Nathalie, Kuszak, Adam J., Tajkhorshid, Emad, Bernstein, Harris D., Buchanan, Susan K.

“…Autotransporters are secreted proteins produced by pathogenic Gram-negative bacteria. They consist of a membrane-embedded β-domain and an extracellular…”
Get full text

Selective Pressure for Rapid Membrane Integration Constrains the Sequence of Bacterial Outer Membrane Proteins by Plummer, Ashlee M., Peterson, Janine H., Bernstein, Harris D., Fleming, Karen G.

Get full text

Mechanistic link between [Beta] barrel assembly and the initiation of autotransporter secretion by Pavlova, Olga, Peterson, Janine H, Ieva, Raffaele, Bernstein, Harris D

“…Autotransporters are bacterial virulence factors that contain an N-terminal extracellular ("passenger") domain and a C-terminal β barrel ("β") domain that…”
Get full text

Mechanistic link between β barrel assembly and the initiation of autotransporter secretion by Pavlova, Olga, Peterson, Janine H., leva, Raffaele, Bernstein, Harris D.

Get full text