Search Results - "Peterson, James J"

Highly Efficient Delivery of Adeno-Associated Viral Vectors to the Primate Retina by Boye, Shannon E, Alexander, John J, Witherspoon, C Douglas, Boye, Sanford L, Peterson, James J, Clark, Mark E, Sandefer, Kristen J, Girkin, Chris A, Hauswirth, William W, Gamlin, Paul D

“…Adeno-associated virus (AAV) has emerged as the preferred vector for targeting gene expression to the retina. Subretinally injected AAV can efficiently…”
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Effects of Altering Heparan Sulfate Proteoglycan Binding and Capsid Hydrophilicity on Retinal Transduction by Adeno-associated Virus by Crosson, Sean M, Bennett, Antonette, Fajardo, Diego, Peterson, James J, Zhang, Hangning, Li, Wei, Leahy, Matthew T, Jennings, Colin K, Boyd, Ryan F, Boye, Sanford L, Agbandje-McKenna, Mavis, Boye, Shannon E

“…Adeno-associated viruses (AAVs) have recently emerged as the leading vector for retinal gene therapy. However, AAV vectors that are capable of achieving…”
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Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat by Bogner, Barbara, Boye, Sanford L, Min, Seok Hong, Peterson, James J, Ruan, Qing, Zhang, Zhonghong, Reitsamer, Herbert A, Hauswirth, William W, Boye, Shannon E

“…Adeno associated virus (AAV) is well known for its ability to deliver transgenes to retina and to mediate improvements in animal models and patients with…”
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A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies by Calabro, Kaitlyn R, Boye, Sanford L, Choudhury, Shreyasi, Fajardo, Diego, Peterson, James J, Li, Wei, Crosson, Sean M, Kim, Mi-Jung, Ding, Dalian, Salvi, Richard, Someya, Shinichi, Boye, Shannon E

“…Usher's syndrome is the most common combined blindness-deafness disorder with USH1B, caused by mutations in , resulting in the most severe phenotype. The…”
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Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection by Lipinski, Daniel M, Reid, Chris A, Boye, Sanford L, Peterson, James J, Qi, Xiaoping, Boye, Shannon E, Boulton, Michael E, Hauswirth, William W

“…The ability to effectively deliver genetic material to vascular endothelial cells remains one of the greatest unmet challenges facing the development of gene…”
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Preclinical studies in support of phase I/II clinical trials to treat GUCY2D-associated Leber congenital amaurosis by Boye, Sanford L., O’Riordan, Catherine, Morris, James, Lukason, Michael, Compton, David, Baek, Rena, Elmore, Dana M., Peterson, James.J., Fajardo, Diego, McCullough, K. Tyler, Scaria, Abraham, McVie-Wylie, Alison, Boye, Shannon E.

“…Mutations in GUCY2D are associated with severe early-onset retinal dystrophy, Leber congenital amaurosis type 1 (LCA1), a leading cause of blindness in…”
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Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque by McCullough, K Tyler, Boye, Sanford L, Fajardo, Diego, Calabro, Kaitlyn, Peterson, James J, Strang, Christianne E, Chakraborty, Dibyendu, Gloskowski, Sebastian, Haskett, Scott, Samuelsson, Steven, Jiang, Haiyan, Witherspoon, C Douglas, Gamlin, Paul D, Maeder, Morgan L, Boye, Shannon E

“…Mutations in , the gene encoding retinal guanylate cyclase-1 (retGC1), are the leading cause of autosomal dominant cone-rod dystrophy (CORD6). Significant…”
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Cone-Specific Promoters for Gene Therapy of Achromatopsia and Other Retinal Diseases by Ye, Guo-Jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T Michael, Sheibani, Nader, Gurel, Zafer, Boye, Sanford L, Peterson, James J, Boye, Shannon E, Hauswirth, William W, Chulay, Jeffrey D

“…Adeno-associated viral (AAV) vectors containing cone-specific promoters have rescued cone photoreceptor function in mouse and dog models of achromatopsia, but…”
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Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations by Beltran, William A., Cideciyan, Artur V., Boye, Shannon E., Ye, Guo-Jie, Iwabe, Simone, Dufour, Valerie L., Marinho, Luis Felipe, Swider, Malgorzata, Kosyk, Mychajlo S., Sha, Jin, Boye, Sanford L., Peterson, James J., Witherspoon, C. Douglas, Alexander, John J., Ying, Gui-Shuang, Shearman, Mark S., Chulay, Jeffrey D., Hauswirth, William W., Gamlin, Paul D., Jacobson, Samuel G., Aguirre, Gustavo D.

“…X-linked retinitis pigmentosa (XLRP) caused by mutations in the RPGR gene is an early onset and severe cause of blindness. Successful proof-of-concept studies…”
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Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1 by Boye, Sanford L, Peterson, James J, Choudhury, Shreyasi, Min, Seok Hong, Ruan, Qing, McCullough, K Tyler, Zhang, Zhonghong, Olshevskaya, Elena V, Peshenko, Igor V, Hauswirth, William W, Ding, Xi-Qin, Dizhoor, Alexander M, Boye, Shannon E

“…Mutations in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). GUCY2D encodes retinal guanylate cyclase-1 (retGC1), a protein expressed…”
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A Role for Cytoskeletal Elements in the Light-Driven Translocation of Proteins in Rod Photoreceptors by Peterson, James J, Orisme, Wilda, Fellows, Jonathan, McDowell, J. Hugh, Shelamer, Charles L, Dugger, Donald R, Smith, W. Clay

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Preclinical Evaluation of Cathepsin-degradable Peptide Linkers for Radioimmunoconjugates by DeNardo, Gerald L, DeNardo, Sally J, Peterson, James J, Miers, Laird A, Lam, Kit S, Hartmann-Siantar, Christine, Lamborn, Kathleen R

“…Purpose: Immunoglobulins are catabolized in the hepatocytes, primarily by cathepsins. The liver becomes the likely dose-limiting tissue for radiometals, like…”
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Total Solid-Phase Synthesis of 1,4,7,10-Tetraazacyclododecane-N,N ‘,N ‘ ‘,N ‘ ‘ ‘-tetraacetic Acid-Functionalized Peptides for Radioimmunotherapy by Peterson, James J, Pak, Roger H, Meares, Claude F

“…A convenient approach to the functionalization of peptides with the macrocyclic 1,4,7,10-tetraazacyclododecane-N,N‘,N‘ ‘,N‘ ‘‘-tetraacetic acid (DOTA) moiety…”
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Optimizing cellulase usage for improved mixing and rheological properties of acid-pretreated sugarcane bagasse by Geddes, Claudia C., Peterson, James J., Mullinnix, Michael T., Svoronos, Spyros A., Shanmugam, K.T., Ingram, Lonnie O.

“…Consolidation of bioprocessing steps with lignocellulose is limited by hydrolysate toxicity, the fibrous nature of suspensions, and low activity of cellulase…”
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Arrestin migrates in photoreceptors in response to light: a study of arrestin localization using an arrestin-GFP fusion protein in transgenic frogs by Peterson, James J., Tam, Beatrice M., Moritz, Orson L., Shelamer, Charles L., Dugger, Donald R., McDowell, J.Hugh, Hargrave, Paul A., Papermaster, David S., Smith, W.Clay

“…Subcellular translocation of phototransduction proteins in response to light has previously been detected by immunocytochemistry. This movement is consistent…”
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Probing alpha-crystallin structure using chemical cross-linkers and mass spectrometry by Peterson, James J, Young, Malin M, Takemoto, Larry J

“…Alternatives to X-ray crystallographic techniques are needed to probe the structure of the hetero-oligomeric lens protein alpha-crystallin. We utilized mass…”
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The surface of visual arrestin that binds to rhodopsin by Smith, W Clay, Dinculescu, Astra, Peterson, James J, McDowell, J Hugh

“…The binding of visual arrestin to phosphorylated, activated rhodopsin serves as a model for studying the inactivation process of a large class of G-protein…”
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Cathepsin Substrates as Cleavable Peptide Linkers in Bioconjugates, Selected from a Fluorescence Quench Combinatorial Library by Peterson, James J, Meares, Claude F

“…Several extended peptide substrates for the human liver enzymes cathepsin B and cathepsin D have been selected as cleavable linkers for lysosomal proteolysis…”
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Arrestin translocation in rod photoreceptors by Smith, W Clay, Peterson, James J, Orisme, Wilda, Dinculescu, Astra

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Enzymatic Cleavage of Peptide-Linked Radiolabels from Immunoconjugates by Peterson, James J, Meares, Claude F

“…We have incorporated peptides selected by combinatorial library [Peterson, J. J., and Meares, C. F. (1998) Bioconjugate Chem. 9, 618−626) into peptide-linked…”
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