Search Results - "Peterson, Jake"
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Identification of MYC intron 2 regions that modulate expression
Published in PloS one (18-01-2024)“…MYC pre-mRNA is spliced with high fidelity to produce the transcription factor known to regulate cellular differentiation, proliferation, apoptosis, and…”
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Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
Published in ACS central science (28-10-2020)“…COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it. Herein, we designed multiple bioactive small molecules that…”
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Structure of the SARS-CoV‑2 Frameshift Stimulatory Element with an Upstream Multibranch Loop
Published in Biochemistry (Easton) (21-05-2024)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshift stimulatory element (FSE) is necessary for programmed −1 ribosomal frameshifting…”
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In silico analysis of local RNA secondary structure in influenza virus A, B and C finds evidence of widespread ordered stability but little evidence of significant covariation
Published in Scientific reports (10-01-2022)“…Influenza virus is a persistent threat to human health; indeed, the deadliest modern pandemic was in 1918 when an H1N1 virus killed an estimated 50 million…”
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Universal and strain specific structure features of segment 8 genomic RNA of influenza A virus—application of 4-thiouridine photocrosslinking
Published in The Journal of biological chemistry (01-12-2021)“…RNA structure in the influenza A virus (IAV) has been the focus of several studies that have shown connections between conserved secondary structure motifs and…”
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In vivo secondary structural analysis of Influenza A virus genomic RNA
Published in Cellular and molecular life sciences : CMLS (01-05-2023)“…Influenza A virus (IAV) is a respiratory virus that causes epidemics and pandemics. Knowledge of IAV RNA secondary structure in vivo is crucial for a better…”
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Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication
Published in Antiviral research (01-08-2024)“…SARS-CoV-2 is a betacoronavirus that causes COVID-19, a global pandemic that has resulted in many infections, deaths, and socio-economic challenges. The virus…”
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Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in a Cellular Environment
Published in International journal of molecular sciences (23-02-2022)“…Influenza A virus (IAV) is a member of the single-stranded RNA (ssRNA) family of viruses. The most recent global pandemic caused by the SARS-CoV-2 virus has…”
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A map of the SARS-CoV-2 RNA structurome
Published in NAR genomics and bioinformatics (01-06-2021)“…Abstract SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain insights into SARS-CoV-2 biology and to target the virus…”
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Discovery of RNA secondary structural motifs using sequence-ordered thermodynamic stability and comparative sequence analysis
Published in MethodsX (01-12-2023)“…Major advances in RNA secondary structural motif prediction have been achieved in the last few years; however, few methods harness the predictive power of…”
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Photolysis of dinitrobenzyl alcohols, dinitrobenzaldehydes, and nitrobenzoic acids in seawater, estuary water, and pure water
Published in Marine chemistry (20-11-2012)“…Photolytic transformation of the propellants 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) produces 2,4-dinitrobenzyl alcohol (2,4-DNBOH),…”
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Thermodynamic Stability of hnRNP A1 Low Complexity Domain Revealed by High-Pressure NMR
Published in Biophysical journal (12-02-2021)Get full text
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Thermodynamic stability of hnRNP A1 low complexity domain revealed by high‐pressure NMR
Published in Proteins, structure, function, and bioinformatics (01-07-2021)“…We have investigated the pressure‐ and temperature‐induced conformational changes associated with the low complexity domain of hnRNP A1, an RNA‐binding protein…”
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High-Throughput Characterization of RNA Structural Motifs
Published 01-01-2024“…Ribonucleic acids (RNAs) are essential to all forms of life. Due to thermodynamic pressures, RNAs have a propensity to fold and form structures either within…”
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The association between white blood cell count and outcomes in patients with idiopathic pulmonary fibrosis
Published in Respiratory medicine (01-08-2020)“…The course of idiopathic pulmonary fibrosis (IPF) is uncertain with variable patterns of disease progression. We sought to evaluate the prognostic utility of…”
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Identification of MYC intron 2 regions that modulate expression
Published in PloS one (01-01-2024)Get full text
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