Search Results - "Peterson, Cristina D."

Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects by Larson, Christina M, Barajas, Cecilia, Kitto, Kelley F, Wilcox, George L, Fairbanks, Carolyn A, Peterson, Cristina D

“…Buprenorphine in an extended-release formulation intended for use in laboratory subjects is frequently administered to rats to provide extended analgesia…”
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The opioid receptor: emergence through millennia of pharmaceutical sciences by Fairbanks, Carolyn A., Peterson, Cristina D.

“…Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review…”
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Effect of chronic pain on fentanyl self-administration in mice by Wade, Carrie L, Krumenacher, Perry, Kitto, Kelley F, Peterson, Cristina D, Wilcox, George L, Fairbanks, Carolyn A

“…The development of opioid addiction in subjects with established chronic pain is an area that is poorly understood. It is critically important to clearly…”
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Mechanistic Chronopharmacology: Preclinical Modeling of an SGLT2 Inhibitor in Preventing Painful Diabetic Neuropathy by Cignarella, Andrea, Peterson, Cristina D

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Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance by Churchill, Caroline C, Peterson, Cristina D, Kitto, Kelley F, Pflepsen, Kelsey R, Belur, Lalitha R, McIvor, R Scott, Vulchanova, Lucy, Wilcox, George L, Fairbanks, Carolyn A

“…Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic…”
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The JPET Editorial Fellowship: Opening the Blinds to the Peer Review and Editorial Process by Ladumor, Mayur K, Mielnik, Catharine A, Peterson, Cristina D, Rwere, Freeborn, Gross, Eric R

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Strategically Substituted Agmatine Analogs Reduce Neuropathic Pain and Show Improved Pharmacokinetics Compared to Agmatine by Clements, Benjamin M., Peterson, Cristina D., Kitto, Kelley F., Wilcox, George L., Fairbanks, Carolyn A.

“…Chronic pain remains a serious issue, affecting millions in the United States. Opioids serve as the most powerful therapeutic option but show limited efficacy…”
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Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine by Peterson, Cristina D., Waataja, Jonathan J., Kitto, Kelley F., Erb, Samuel J., Verma, Harsha, Schuster, Daniel J., Churchill, Caroline C., Riedl, Maureen S., Belur, Lalitha R., Wolf, Daniel A., McIvor, R. Scott, Vulchanova, Lucy, Wilcox, George L., Fairbanks, Carolyn A.

“…Chronic pain remains a significant burden worldwide, and treatments are often limited by safety or efficacy. The decarboxylated form of L-arginine, agmatine,…”
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Sustained-release buprenorphine induces acute opioid tolerance in the mouse by Larson, Christina M., Peterson, Cristina D., Kitto, Kelley F., Wilcox, George L., Fairbanks, Carolyn A.

“…Sustained-release buprenorphine is widely used in mice with the intention of providing long-lasting analgesia. Statements about duration of therapeutic…”
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Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity by Griffith, Jessica I, Kim, Minjee, Bruce, Daniel J, Peterson, Cristina D, Kitto, Kelley F, Mohammad, Afroz S, Rathi, Sneha, Fairbanks, Carolyn A, Wilcox, George L, Elmquist, William F

“…Novel combinations of specific opioid agonists like loperamide and oxymorphindole targeting the - and -opioid receptors, respectively, have shown increased…”
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Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice by Bruce, Daniel J, Peterson, Cristina D, Kitto, Kelley F, Akgün, Eyup, Lazzaroni, Sophia, Portoghese, Phillip S, Fairbanks, Carolyn A, Wilcox, George L

“…WHAT WE ALREADY KNOW ABOUT THIS TOPICThe adverse effects of opioids are largely mediated by central μ-opioid receptorsCentral μ- and δ-opioid receptors…”
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Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain by Peterson, Cristina D, Kitto, Kelley F, Verma, Harsha, Pflepsen, Kelsey, Delpire, Eric, Wilcox, George L, Fairbanks, Carolyn A

“…A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs containing Glun2B subunits within the spinal cord and lacks motor side effects…”
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Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord by Waataja, Jonathan J, Peterson, Cristina D, Verma, Harsha, Goracke-Postle, Cory J, Séguéla, Philippe, Delpire, Eric, Wilcox, George L, Fairbanks, Carolyn A

“…The role of the N-methyl-d-aspartate receptor (NMDAr) as a contributor to maladaptive neuroplasticity underlying the maintenance of chronic pain is well…”
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Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice by Peterson, Cristina D., Kitto, Kelley F., Akgün, Eyup, Lunzer, Mary M., Riedl, Maureen S., Vulchanova, Lucy, Wilcox, George L., Portoghese, Philip S., Fairbanks, Carolyn A.

“…The mu opioid receptor (MOR) and metabotropic glutamate receptor 5 (mGluR5) are well-established pharmacological targets in the management of chronic pain…”
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Biodistribution of Adeno-Associated Virus Serotype 5 Viral Vectors Following Intrathecal Injection by Pflepsen, Kelsey R, Peterson, Cristina D, Kitto, Kelley F, Riedl, Maureen S, McIvor, R. Scott, Wilcox, George L, Vulchanova, Lucy, Fairbanks, Carolyn A

“…The pharmacokinetic profile of AAV particles following intrathecal delivery has not yet been clearly defined. The present study evaluated the distribution…”
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Involvement of the VGF-derived peptide TLQP-62 in nerve injury–induced hypersensitivity and spinal neuroplasticity by Skorput, Alexander G. J., Zhang, Xijing, Waataja, Jonathan J., Peterson, Cristina D., Riedl, Maureen S., Kitto, Kelley F., Truong, Hai, Huffman, Cecilia, Salton, Stephen R., Fairbanks, Carolyn A., Honda, Christopher N., Vulchanova, Lucy

“…Neuroplasticity in the dorsal horn after peripheral nerve damage contributes critically to the establishment of chronic pain. The neurosecretory protein VGF…”
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AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection by Peterson, Cristina D, Skorput, Alexander G J, Kitto, Kelley F, Wilcox, George L, Vulchanova, Lucy, Fairbanks, Carolyn A

“…Gene therapy targeting the spinal cord is an important tool for analyzing mechanisms of nervous system diseases and the development of gene therapies…”
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The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity by Fairbanks, Carolyn A., Peterson, Cristina D., Speltz, Rebecca H., Riedl, Maureen S., Kitto, Kelley F., Dykstra, Jaclyn A., Braun, Patrick D., Sadahiro, Masato, Salton, Stephen R., Vulchanova, Lucy

“…The endogenous VGF-derived peptide TLQP-21 contributes to the development and maintenance of inflammatory and nerve injury-induced hypersensitivity. VGF…”
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Involvement of the VGF-derived peptide TLQP-62 in nerve injury-induced hypersensitivity and spinal neuroplasticity by Skorput, Alexander G J, Zhang, Xijing, Waataja, Jonathan J, Peterson, Cristina D, Riedl, Maureen S, Kitto, Kelley F, Truong, Hai, Huffman, Cecilia, Salton, Stephen R, Fairbanks, Carolyn A, Honda, Christopher N, Vulchanova, Lucy

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Alleviation of Chronic Neuropathic Pain by Agmatine Requires the GluN2B Subunit of the NMDA Receptor by Peterson, Cristina D

“…Effective treatment for chronic pain patients remains an area of largely unmet need. However, chronic pain patients receiving traditional opioid therapy are…”
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