Search Results - "Petersen, T. Neves"
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Role of Solvent, pH, and Molecular Size in Excited-State Deactivation of Key Eumelanin Building Blocks: Implications for Melanin Pigment Photostability
Published in Journal of the American Chemical Society (17-12-2008)“…Ultrafast time-resolved fluorescence spectroscopy has been used to investigate the excited-state dynamics of the basic eumelanin building block…”
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Novel photonic technique creates micrometer resolution protein arrays and provides a new approach to coupling of genes, peptide hormones and drugs to nanoparticle carriers
Published in Applied surface science (31-07-2007)“…We demonstrate that ultraviolet light can be used to make sterically oriented covalent immobilization of a large variety of protein molecules onto either…”
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Journal Article Conference Proceeding -
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Quantization of pH: Evidence for Acidic Activity of Triglyceride Lipases
Published in Biochemistry (Easton) (30-08-2005)“…Here we present a study of lipolytic activity of lipases from Fusarium solani pisi (cutinase), Rhizomucor miehei, Pseudomonas cepacia, and Humicola lanuginosa…”
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Luminescence decay of oriented phenylene nanofibers
Published in Physical review. B, Condensed matter and materials physics (01-09-2005)Get full text
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A thermostable salmonella phage endolysin, Lys68, with broad bactericidal properties against gram-negative pathogens in presence of weak acids
Published in PloS one (07-10-2014)“…Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This…”
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UV light blocks EGFR signalling in human cancer cell lines
Published in International journal of oncology (01-01-2007)“…UV light excites aromatic residues, causing these to disrupt nearby disulphide bridges. The EGF receptor is rich in aromatic residues near the disulphide…”
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Quenchers induce wavelength dependence on protein fluorescence lifetimes
Published in Journal of fluorescence (01-07-2006)“…We have analysed the picosecond resolved fluorescence emission decay of horseradish peroxidase A2 and of HEW lysozyme acquired with a streak camera. Analyses…”
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Photonic modulation of epidermal growth factor receptor halts receptor activation and cancer cell migration
Published in Journal of biophotonics (01-09-2018)“…Epidermal Growth Factor Receptor (EGFR) plays a key role in regulating cell survival, proliferation and migration, and its overexpression and activation has…”
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Journal Article -
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Engineering the pH-optimum of a triglyceride lipase: from predictions based on electrostatic computations to experimental results
Published in Journal of biotechnology (18-05-2001)“…The optimisation of enzymes for particular purposes or conditions remains an important target in virtually all protein engineering endeavours. Here, we present…”
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Modulating the structure of EGFR with UV light: new possibilities in cancer therapy
Published in PloS one (11-11-2014)“…The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. EGFR is activated upon binding to e.g. epidermal…”
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How do lipases and esterases work: the electrostatic contribution
Published in Journal of biotechnology (13-02-2001)“…This work explores the role of one of the factors explaining lipase/esterase activity: the contribution of electrostatic interactions to lipase/esterase…”
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Long wavelength depolarized light scattering from silver nanoparticles
Published in Chemical physics letters (27-07-2007)“…Dimensions of the silver particles used to model their scattering anisotropy and compare with experimental values. We report the depolarized light scattering…”
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Photonic activation of disulfide bridges achieves oriented protein immobilization on biosensor surfaces
Published in Protein science (01-02-2006)“…Photonic induced immobilization is a novel technology that results in spatially oriented and spatially localized covalent coupling of biomolecules onto…”
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UV light blocks EGFR signalling in human cancer cell lines
Published in International journal of oncology (2006)Get full text
Journal Article -
15
Protein electrostatics: A review of the equations and methods used to model electrostatic equations in biomolecules – Applications in biotechnology
Published in Biotechnology Annual Review (2003)“…The molecular understanding of the initial interaction between a protein and, e.g., its substrate, a surface or an inhibitor is essentially an understanding of…”
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Book Chapter Journal Article -
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High probability of disrupting a disulphide bridge mediated by an endogenous excited tryptophan residue
Published in Protein science (01-03-2002)“…It is well known that ultraviolet (UV) radiation may reduce or even abolish the biological activity of proteins and enzymes. UV light, as a component of…”
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Towards a molecular level understanding of protein stabilization: the interaction between lysozyme and sorbitol
Published in Journal of biotechnology (13-06-1997)“…The paper is investigating the mechanism of stabilization of proteins by polyols at the molecular level. It is addressing the interactions of sorbitol, a…”
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Oriented coupling of major histocompatibility complex (MHC) to sensor surfaces using light assisted immobilisation technology
Published in Biosensors & bioelectronics (15-02-2006)“…Controlled and oriented immobilisation of proteins for biosensor purposes is of extreme interest since this provides more efficient sensors with a larger…”
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Journal Article -
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Heme and pH-dependent stability of an anionic horseradish peroxidase
Published in Archives of biochemistry and biophysics (15-07-2003)“…Horseradish peroxidase A1 thermal stability was studied by steady-state fluorescence, circular dichroism and differential scanning calorimetry at pH values of…”
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Journal Article -
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Enzymatic lipid removal from surfaces—lipid desorption by a pH-induced “electrostatic explosion”
Published in Chemistry and physics of lipids (2005)“…Removal of lipidic molecules from surfaces can be accomplished using detergents containing lipases. Surface cleaning is usually performed under alkaline…”
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