Search Results - "Petersen, Ronald C"

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives by Baker, Darren J, Petersen, Ronald C

“…Along with a general decline in overall health, most chronic degenerative human diseases are inherently associated with increasing age. Age-associated…”
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Mild Cognitive Impairment and Mild Dementia: A Clinical Perspective by Knopman, David S., MD, Petersen, Ronald C., PhD, MD

“…Abstract Mild cognitive impairment and mild dementia are common problems in the elderly. Primary care physicians are the first point of contact for most…”
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Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics by Trushina, Eugenia, Dutta, Tumpa, Persson, Xuan-Mai T, Mielke, Michelle M, Petersen, Ronald C

“…Alzheimer's Disease (AD) currently affects more than 5 million Americans, with numbers expected to grow dramatically as the population ages. The…”
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Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging by Ahlskog, J. Eric, PhD, MD, Geda, Yonas E., MD, MSc, Graff-Radford, Neill R., MBBCh, FRCP, Petersen, Ronald C., PhD, MD

“…A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk. We…”
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Normative spatiotemporal gait parameters in older adults by Hollman, John H, McDade, Eric M, Petersen, Ronald C

“…Abstract While factor analyses have characterized pace, rhythm and variability as factors that explain variance in gait performance in older adults,…”
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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers by Jack, Clifford R, Prof Dr, Knopman, David S, Prof, Jagust, William J, Prof, Petersen, Ronald C, Prof, Weiner, Michael W, Prof, Aisen, Paul S, Prof, Shaw, Leslie M, Prof, Vemuri, Prashanthi, PhD, Wiste, Heather J, Weigand, Stephen D, Lesnick, Timothy G, Pankratz, Vernon S, PhD, Donohue, Michael C, PhD, Trojanowski, John Q, Prof

“…Summary In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease (AD). The model was received with interest because we…”
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Mild Cognitive Impairment in Geriatrics by Tangalos, Eric G., MD, Petersen, Ronald C., MD, PhD

“…Mild cognitive impairment remains a clinical diagnosis, aided by history, neurologic examination, screening mental status examination, and secondary testing…”
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Cascading network failure across the Alzheimer's disease spectrum by Jones, David T, Knopman, David S, Gunter, Jeffrey L, Graff-Radford, Jonathan, Vemuri, Prashanthi, Boeve, Bradley F, Petersen, Ronald C, Weiner, Michael W, Jack, Jr, Clifford R

“…Complex biological systems are organized across various spatiotemporal scales with particular scientific disciplines dedicated to the study of each scale (e.g…”
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Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline by Ossenkoppele, Rik, Pichet Binette, Alexa, Groot, Colin, Smith, Ruben, Strandberg, Olof, Palmqvist, Sebastian, Stomrud, Erik, Tideman, Pontus, Ohlsson, Tomas, Jögi, Jonas, Johnson, Keith, Sperling, Reisa, Dore, Vincent, Masters, Colin L., Rowe, Christopher, Visser, Denise, van Berckel, Bart N. M., van der Flier, Wiesje M., Baker, Suzanne, Jagust, William J., Wiste, Heather J., Petersen, Ronald C., Jack, Clifford R., Hansson, Oskar

“…A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological hallmarks…”
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Mild Cognitive Impairment: An Overview by Petersen, Ronald C., Negash, Selamawit

“…Mild cognitive impairment (MCI) refers to the transitional state between the cognitive changes of normal aging and very early dementia. MCI has generated a…”
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Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease by Kapogiannis, Dimitrios, Boxer, Adam, Schwartz, Janice B., Abner, Erin L., Biragyn, Arya, Masharani, Umesh, Frassetto, Lynda, Petersen, Ronald C., Miller, Bruce L., Goetzl, Edward J.

“…ABSTRACT Insulin resistance causes diminished glucose uptake in similar regions of the brain in Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2)…”
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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study by Fiandaca, Massimo S, Kapogiannis, Dimitrios, Mapstone, Mark, Boxer, Adam, Eitan, Erez, Schwartz, Janice B, Abner, Erin L, Petersen, Ronald C, Federoff, Howard J, Miller, Bruce L, Goetzl, Edward J

“…Abstract Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers…”
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Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study by Murray, Melissa E, PhD, Graff-Radford, Neill R, Prof, Ross, Owen A, PhD, Petersen, Ronald C, Prof, Duara, Ranjan, MD, Dickson, Dennis W, Prof

“…Summary Background Neurofibrillary pathology has a stereotypical progression in Alzheimer's disease (AD) that is encapsulated in the Braak staging scheme;…”
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Reply to “Thinking beyond Aducanumab Controversy” by Petersen, Ronald

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Defining imaging biomarker cut points for brain aging and Alzheimer's disease by Jack, Clifford R, Wiste, Heather J, Weigand, Stephen D, Therneau, Terry M, Lowe, Val J, Knopman, David S, Gunter, Jeffrey L, Senjem, Matthew L, Jones, David T, Kantarci, Kejal, Machulda, Mary M, Mielke, Michelle M, Roberts, Rosebud O, Vemuri, Prashanthi, Reyes, Denise A, Petersen, Ronald C

“…Abstract Introduction Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro-deoxyglucose (FDG) PET, and MRI…”
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Amyloid deposition, hypometabolism, and longitudinal cognitive decline by Landau, Susan M., Mintun, Mark A., Joshi, Abhinay D., Koeppe, Robert A., Petersen, Ronald C., Aisen, Paul S., Weiner, Michael W., Jagust, William J.

“…Objective: Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) population, we examined (1) cross‐sectional relationships between amyloid…”
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Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia by Roberts, Rosebud O, Christianson, Teresa J H, Kremers, Walter K, Mielke, Michelle M, Machulda, Mary M, Vassilaki, Maria, Alhurani, Rabe E, Geda, Yonas E, Knopman, David S, Petersen, Ronald C

“…To increase the opportunity to delay or prevent mild cognitive impairment (MCI) or Alzheimer disease (AD) dementia, markers of early detection are essential…”
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Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study by Whitwell, Jennifer L, Dr, Dickson, Dennis W, Prof, Murray, Melissa E, PhD, Weigand, Stephen D, MS, Tosakulwong, Nirubol, BS, Senjem, Matthew L, MS, Knopman, David S, Prof, Boeve, Bradley F, Prof, Parisi, Joseph E, Prof, Petersen, Ronald C, Prof, Jack, Clifford R, Prof, Josephs, Keith A, Prof

“…Summary Background Three subtypes of Alzheimer's disease (AD) have been pathologically defined on the basis of the distribution of neurofibrillary tangles:…”
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Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression by Yamazaki, Yu, Shinohara, Mitsuru, Shinohara, Motoko, Yamazaki, Akari, Murray, Melissa E, Liesinger, Amanda M, Heckman, Michael G, Lesser, Elizabeth R, Parisi, Joseph E, Petersen, Ronald C, Dickson, Dennis W, Kanekiyo, Takahisa, Bu, Guojun

“…Impairment of blood-brain barrier integrity has been implicated in Alzheimer's disease. Yamazaki et al. show that the loss of cortical tight junction proteins…”
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Non-stationarity in the "resting brain's" modular architecture by Jones, David T, Vemuri, Prashanthi, Murphy, Matthew C, Gunter, Jeffrey L, Senjem, Matthew L, Machulda, Mary M, Przybelski, Scott A, Gregg, Brian E, Kantarci, Kejal, Knopman, David S, Boeve, Bradley F, Petersen, Ronald C, Jack, Jr, Clifford R

“…Task-free functional magnetic resonance imaging (TF-fMRI) has great potential for advancing the understanding and treatment of neurologic illness. However, as…”
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