Search Results - "Petersen, Rasmus K."

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity by Madsen, Lise, Pedersen, Lone M, Lillefosse, Haldis Haukaas, Fjaere, Even, Bronstad, Ingeborg, Hao, Qin, Petersen, Rasmus K, Hallenborg, Philip, Ma, Tao, De Matteis, Rita, Araujo, Pedro, Mercader, Josep, Bonet, M Luisa, Hansen, Jacob B, Cannon, Barbara, Nedergaard, Jan, Wang, Jun, Cinti, Saverio, Voshol, Peter, Døskeland, Stein Ove, Kristiansen, Karsten

“…The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Here we report that cyclooxygenase…”
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Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists by Qvortrup, Katrine, Jensen, Jakob F, Sørensen, Mikael S, Kouskoumvekaki, Irene, Petersen, Rasmus K, Taboureau, Olivier, Kristiansen, Karsten, Nielsen, Thomas E

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a well-known target for thiazolidinedione antidiabetic drugs. In this paper, we present the synthesis…”
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Retinoblastoma Protein Functions as a Molecular Switch Determining White versus Brown Adipocyte Differentiation by Hansen, Jacob B., Jørgensen, Claus, Petersen, Rasmus K., Hallenborg, Philip, De Matteis, Rita, Bøye, Hans A., Petrovic, Natasa, Enerbäck, Sven, Nedergaard, Jan, Cinti, Saverio, Riele, Hein te, Kristiansen, Karsten, Spiegelman, Bruce M.

“…Adipocyte precursor cells give raise to two major cell populations with different physiological roles: white and brown adipocytes. Here we demonstrate that the…”
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Epidermis-Type Lipoxygenase 3 Regulates Adipocyte Differentiation and Peroxisome Proliferator-Activated Receptor γ Activity by Hallenborg, Philip, Jørgensen, Claus, Petersen, Rasmus K., Feddersen, Søren, Araujo, Pedro, Markt, Patrick, Langer, Thierry, Furstenberger, Gerhard, Krieg, Peter, Koppen, Arjen, Kalkhoven, Eric, Madsen, Lise, Kristiansen, Karsten

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Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α by Kang, Sona, Bajnok, Laszlo, Longo, Kenneth A., Petersen, Rasmus K., Hansen, Jacob B., Kristiansen, Karsten, MacDougald, Ormond A.

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Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process by Madsen, Lise, Petersen, Rasmus K, Sørensen, Morten B, Jørgensen, Claus, Hallenborg, Philip, Pridal, Lone, Fleckner, Jan, Amri, Ez-Zoubir, Krieg, Peter, Furstenberger, Gerhard, Berge, Rolf K, Kristiansen, Karsten

“…Adipocytes play a central role in whole-body energy homoeostasis. Complex regulatory transcriptional networks control adipogensis, with ligand-dependent…”
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The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects by Hallenborg, Philip, Petersen, Rasmus K., Kouskoumvekaki, Irene, Newman, John W., Madsen, Lise, Kristiansen, Karsten

“…The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated…”
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Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases by Christiansen, Elisabeth, Watterson, Kenneth R., Stocker, Claire J., Sokol, Elena, Jenkins, Laura, Simon, Katharina, Grundmann, Manuel, Petersen, Rasmus K., Wargent, Edward T., Hudson, Brian D., Kostenis, Evi, Ejsing, Christer S., Cawthorne, Michael A., Milligan, Graeme, Ulven, Trond

“…Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mechanisms of action are…”
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Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism by Wein, Silvia, Behm, Norma, Petersen, Rasmus K., Kristiansen, Karsten, Wolffram, Siegfried

“…To study possible insulin sensitizing, anti-inflammatory and anti-oxidative effects of the flavonol quercetin, rats were fed a high-fat diet (19%, w/w) with…”
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Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases by Petersen, Rasmus K., J⊘rgensen, Claus, Rustan, Arild C., Fr⊘yland, Livar, Muller-Decker, Karin, Furstenberger, Gerhard, Berge, Rolf K., Kristiansen, Karsten, Madsen, Lise

“…Arachidonic acid inhibits adipocyte differentiation of 3T3-L1 cells via a prostaglandin synthesis-dependent pathway. Here we show that this inhibition requires…”
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Even effect of milk protein and carbohydrate intake but no further effect of heavy resistance exercise on myofibrillar protein synthesis in older men by Reitelseder, Søren, Dideriksen, Kasper, Agergaard, Jakob, Malmgaard-Clausen, Nikolaj M., Bechshoeft, Rasmus L., Petersen, Rasmus K., Serena, Anja, Mikkelsen, Ulla R., Holm, Lars

“…Purpose The responsiveness of older individuals’ skeletal muscle to anabolic strategies may be impaired. However, direct comparisons within the same…”
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Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation by Zhang, Hongbin, Nøhr, Jane, Jensen, Charlotte H., Petersen, Rasmus K., Bachmann, Elin, Teisner, Børge, Larsen, Leif K., Mandrup, Susanne, Kristiansen, Karsten

“…Pref-1 is a highly glycosylated Delta-like transmembrane protein containing six epidermal growth factor-like repeats in the extracellular domain. Pref-1 is…”
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Activation of Liver X Receptors Prevents Statin-induced Death of 3T3-L1 Preadipocytes by Madsen, Lise, Petersen, Rasmus K., Steffensen, Knut R., Pedersen, Lone M., Hallenborg, Philip, Ma, Tao, Frøyland, Livar, Døskeland, Stein Ove, Gustafsson, Jan-Åke, Kristiansen, Karsten

“…The biological functions of liver X receptors (LXRs) α and β have primarily been linked to pathways involved in fatty acid and cholesterol homeostasis. Here we…”
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Deregulated MAPK Activity Prevents Adipocyte Differentiation of Fibroblasts Lacking the Retinoblastoma Protein by Hansen, Jacob B., Petersen, Rasmus K., Jørgensen, Claus, Kristiansen, Karsten

“…A functional retinoblastoma protein (pRB) is required for adipose conversion of preadipocyte cell lines and primary mouse embryo fibroblasts (MEFs) in response…”
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Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) γ by Christensen, Kathrine B, Petersen, Rasmus K, Kristiansen, Karsten, Christensen, Lars P

“…Obesity is one of the predisposing factors for the development of overt Type 2 diabetes (T2D). T2D is caused by a combination of insulin resistance and β-cell…”
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Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARγ activators by Dixit, Vaibhav A., Rathi, Prakash Chandra, Bhagat, Shweta, Gohlke, Holger, Petersen, Rasmus K., Kristiansen, Karsten, Chakraborti, Asit K., Bharatam, Prasad V.

“…Novel Y-shaped barbituric acid (BA) derivatives have been designed using rational methods including molecular docking. Fourteen novel compounds were…”
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Discovery of new PPARγ agonists based on arylopeptoids by Worm-Leonhard, Kasper, Hjelmgaard, Thomas, Petersen, Rasmus K., Kristiansen, Karsten, Nielsen, John

“…In this study we present the design, synthesis and biological evaluation of a small, first-generation library of small molecule aromatic amides based on the…”
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Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening by Markt, Patrick, Petersen, Rasmus K, Flindt, Esben N, Kristiansen, Karsten, Kirchmair, Johannes, Spitzer, Gudrun, Distinto, Simona, Schuster, Daniela, Wolber, Gerhard, Laggner, Christian, Langer, Thierry

“…Peroxisome proliferator-activated receptors (PPARs) are important targets for drugs used in the treatment of atherosclerosis, dyslipidaemia, obesity, type 2…”
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High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice by Hao, Qin, Lillefosse, Haldis H, Fjaere, Even, Myrmel, Lene Secher, Midtbø, Lisa K, Jarlsby, Ragnhild H, Ma, Tao, Jia, Bingbing, Petersen, Rasmus K, Sonne, Si B, Chwalibog, André, Frøyland, Livar, Liaset, Bjørn, Kristiansen, Karsten, Madsen, Lise

“…Fish oil rich in n-3 polyunsaturated fatty acids is known to attenuate diet-induced obesity and adipose tissue inflammation in rodents. Here we aimed to…”
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Discovery of a Novel Selective PPARγ Ligand with Partial Agonist Binding Properties by Integrated in Silico/in Vitro Work Flow by Kouskoumvekaki, Irene, Petersen, Rasmus K, Fratev, Filip, Taboureau, Olivier, Nielsen, Thomas E, Oprea, Tudor I, Sonne, Si B, Flindt, Esben N, Jónsdóttir, Svava Ósk, Kristiansen, Karsten

“…Full agonists to the peroxisome proliferator-activated receptor (PPAR)γ, such as Rosiglitazone, have been associated with a series of undesired side effects,…”
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