Search Results - "Petersen, Ole H"

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T, Baker, Monya, Browne, William J, Clark, Alejandra, Cuthill, Innes C, Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T, Howells, David W, Karp, Natasha A, Lazic, Stanley E, Lidster, Katie, MacCallum, Catriona J, Macleod, Malcolm, Pearl, Esther J, Petersen, Ole H, Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S, Silberberg, Shai D, Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
Get full text

Calcium and ATP control multiple vital functions by Petersen, Ole H., Verkhratsky, Alexei

“…Life on Planet Earth, as we know it, revolves around adenosine triphosphate (ATP) as a universal energy storing molecule. The metabolism of ATP requires a low…”
Get full text

The role of Ca2+ in the pathophysiology of pancreatitis by Gerasimenko, Julia V., Gerasimenko, Oleg V., Petersen, Ole H.

“…Acute pancreatitis is a human disease in which the pancreatic pro‐enzymes, packaged into the zymogen granules of acinar cells, become activated and cause…”
Get full text

Polarized calcium signaling in exocrine gland cells by Petersen, Ole H, Tepikin, Alexei V

“…Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from exocrine glands. The highly polarized exocrine acinar cells have evolved…”
Get full text

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP by Mukherjee, Rajarshi, Mareninova, Olga A, Odinokova, Irina V, Huang, Wei, Murphy, John, Chvanov, Michael, Javed, Muhammad A, Wen, Li, Booth, David M, Cane, Matthew C, Awais, Muhammad, Gavillet, Bruno, Pruss, Rebecca M, Schaller, Sophie, Molkentin, Jeffery D, Tepikin, Alexei V, Petersen, Ole H, Pandol, Stephen J, Gukovsky, Ilya, Criddle, David N, Gukovskaya, Anna S, Sutton, Robert

“…Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific…”
Get more information

Ca²⁺ release-activated Ca²⁺ channel blockade as a potential tool in antipancreatitis therapy by Gerasimenko, Julia V., Gryshchenko, Oleksiy, Ferdek, Pawel E., Stapleton, Eloise, Hébert, Tania O. G., Bychkova, Solomiia, Peng, Shuang, Begg, Malcolm, Gerasimenko, Oleg V., Petersen, Ole H.

“…Alcohol-related acute pancreatitis can be mediated by a combination of alcohol and fatty acids (fatty acid ethyl esters) and is initiated by a sustained…”
Get full text

Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release by Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert

“…Caffeine reduces toxic Ca signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP R)-mediated signalling, but effects of…”
Get more information

Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry by Walsh, Ciara M, Chvanov, Michael, Haynes, Lee P, Petersen, Ole H, Tepikin, Alexei V, Burgoyne, Robert D

“…Ca2+ entry through store-operated Ca2+ channels involves the interaction at ER-PM (endoplasmic reticulum-plasma membrane) junctions of STIM (stromal…”
Get more information

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells by Booth, David M, Murphy, John A, Mukherjee, Rajarshi, Awais, Muhammad, Neoptolemos, John P, Gerasimenko, Oleg V, Tepikin, Alexei V, Petersen, Ole H, Sutton, Robert, Criddle, David N

“…Background & Aims Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We…”
Get full text

Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells by Petersen, Ole H.

“…The pancreatic acinar cell synthesizes many digestive proenzymes, which are packaged into secretory (zymogen) granules and secreted by exocytosis upon the…”
Get full text

Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening by Baumgartner, Heidi K., Gerasimenko, Julia V., Thorne, Christopher, Ferdek, Pawel, Pozzan, Tullio, Tepikin, Alexei V., Petersen, Ole H., Sutton, Robert, Watson, Alastair J.M., Gerasimenko, Oleg V.

“…We have investigated in detail the role of intra-organelle Ca2+ content during induction of apoptosis by the oxidant menadione while changing and monitoring…”
Get full text

Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites by Kusiak, Agnieszka A., Jakubowska, Monika A., Stopa, Kinga B., Zhang, Xiaoying, Huang, Wei, Gerasimenko, Julia V., Gerasimenko, Oleg V., Sutton, Robert, Petersen, Ole H., Ferdek, Pawel E.

“…Alcohol abuse, an increasing problem in developed societies, is one of the leading causes of acute and chronic pancreatitis. Alcoholic pancreatitis is often…”
Get full text

Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells by Criddle, David N., Gillies, Stuart, Baumgartner-Wilson, Heidi K., Jaffar, Mohammed, Chinje, Edwin C., Passmore, Sarah, Chvanov, Michael, Barrow, Stephanie, Gerasimenko, Oleg V., Tepikin, Alexei V., Sutton, Robert, Petersen, Ole H.

“…Oxidative stress may be an important determinant of the severity of acute pancreatitis. One-electron reduction of oxidants generates reactive oxygen species…”
Get full text

Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release by Gerasimenko, Julia V, Charlesworth, Richard M, Sherwood, Mark W, Ferdek, Pawel E, Mikoshiba, Katsuhiko, Parrington, John, Petersen, Ole H, Gerasimenko, Oleg V

“…Graphical abstract…”
Get full text

Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+, and NAADP by Petersen, Ole H, Gerasimenko, Oleg V, Gerasimenko, Julia V

Get full text

A Novel Role for Bcl-2 in Regulation of Cellular Calcium Extrusion by Ferdek, Pawel E., Gerasimenko, Julia V., Peng, Shuang, Tepikin, Alexei V., Petersen, Ole H., Gerasimenko, Oleg V.

“…The antiapoptotic protein Bcl-2 [1, 2] plays important roles in Ca2+ signaling [3] by influencing inositol triphosphate receptors and regulating Ca2+-induced…”
Get full text

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells by Voronina, Svetlana G, Barrow, Stephanie L, Simpson, Alec W.M, Gerasimenko, Oleg V, da Silva Xavier, Gabriela, Rutter, Guy A, Petersen, Ole H, Tepikin, Alexei V

“…Background & Aims Previous studies of pancreatic acinar cells characterized the effects of Ca2+ -releasing secretagogues and substances, inducing acute…”
Get full text

Fatty Acid Ethyl Esters Cause Pancreatic Calcium Toxicity via Inositol Trisphosphate Receptors and Loss of ATP Synthesis by Criddle, David N., Murphy, John, Fistetto, Gregorio, Barrow, Stephanie, Tepikin, Alexei V., Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.

“…Fatty acid ethyl esters are ethanol metabolites inducing sustained, toxic elevations of the acinar cytosolic free calcium ion concentration ([Ca2+]C)…”
Get full text

Editorial: Spotlight on the Background Actors - Physiology and Pathophysiology of Supporting, Accessory and Less Common Cell Types in the Gastrointestinal Tract by Ferdek, Pawel E., Jakubowska, Monika A., Huang, Wei, Petersen, Ole H.

Get full text

Pancreatic protease activation by alcohol metabolite depends on Ca²⁺ release via acid store IP₃ receptors by Gerasimenko, Julia V, Lur, György, Sherwood, Mark W, Ebisui, Etsuko, Tepikin, Alexei V, Mikoshiba, Katsuhiko, Gerasimenko, Oleg V, Petersen, Ole H

“…Toxic alcohol effects on pancreatic acinar cells, causing the often fatal human disease acute pancreatitis, are principally mediated by fatty acid ethyl esters…”
Get full text