Search Results - "Petersen, Kitt F"

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes by Perry, Rachel J., Samuel, Varman T., Petersen, Kitt F., Shulman, Gerald I.

“…Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to…”
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Metabolic control analysis of hepatic glycogen synthesis in vivo by Nozaki, Yuichi, Petersen, Max C., Zhang, Dongyan, Vatner, Daniel F., Perry, Rachel J., Abulizi, Abudukadier, Haedersdal, Sofie, Zhang, Xian-Man, Butrico, Gina M., Samuel, Varman T., Mason, Graeme F., Cline, Gary W., Petersen, Kitt F., Rothman, Douglas L., Shulman, Gerald I.

“…Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen…”
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Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans by ter Horst, Kasper W., Gilijamse, Pim W., Versteeg, Ruth I., Ackermans, Mariette T., Nederveen, Aart J., la Fleur, Susanne E., Romijn, Johannes A., Nieuwdorp, Max, Zhang, Dongyan, Samuel, Varman T., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I., Serlie, Mireille J.

“…Hepatic lipid accumulation has been implicated in the development of insulin resistance, but translational evidence in humans is limited. We investigated the…”
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Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance by Lee, Hui-Young, Choi, Cheol Soo, Birkenfeld, Andreas L., Alves, Tiago C., Jornayvaz, Francois R., Jurczak, Michael J., Zhang, Dongyan, Woo, Dong Kyun, Shadel, Gerald S., Ladiges, Warren, Rabinovitch, Peter S., Santos, Janine H., Petersen, Kitt F., Samuel, Varman T., Shulman, Gerald I.

“…Aging-associated muscle insulin resistance has been hypothesized to be due to decreased mitochondrial function, secondary to cumulative free radical damage,…”
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Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy by Boumezbeur, Fawzi, Mason, Graeme F, de Graaf, Robin A, Behar, Kevin L, Cline, Gary W, Shulman, Gerald I, Rothman, Douglas L, Petersen, Kitt F

“…A decline in brain function is a characteristic feature of healthy aging; however, little is known about the biologic basis of this phenomenon. To determine…”
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Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents by Petersen, Kitt F, Dufour, Sylvie, Shulman, Gerald I

“…Insulin resistance is the best predictor for the development of type 2 diabetes. Recent studies have shown that young, lean, insulin-resistant (IR) offspring…”
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Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism by Choi, Cheol Soo, Befroy, Douglas E, Codella, Roberto, Kim, Sheene, Reznick, Richard M, Hwang, Yu-Jin, Liu, Zhen-Xiang, Lee, Hui-Young, Distefano, Alberto, Samuel, Varman T, Zhang, Dongyan, Cline, Gary W, Handschin, Christoph, Lin, Jiandie, Petersen, Kitt F, Spiegelman, Bruce M, Shulman, Gerald I

“…Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α has been shown to play critical roles in regulating mitochondria biogenesis, respiration, and…”
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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes by Hundal, Ripudaman S, Petersen, Kitt F, Mayerson, Adam B, Randhawa, Pritpal S, Inzucchi, Silvio, Shoelson, Steven E, Shulman, Gerald I

“…Recent studies have implicated fatty acid-dependent activation of the serine kinase IKKbeta, which plays a key role in tissue inflammation, in the pathogenesis…”
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Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats by Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.

“…Genome‐wide array studies have associated the patatin‐like phospholipase domain‐containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis. However, it is…”
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The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes by MAYERSON, Adam B, HUNDAL, Ripudaman S, DUFOUR, Sylvie, LEBON, Vincent, BEFROY, Douglas, CLINE, Gary W, ENOCKSSON, Staffan, INZUCCHI, Silvio E, SHULMAN, Gerald I, PETERSEN, Kitt F

“…The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes Adam B…”
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Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning by Weiss, Ram, Dufour, Sylvie, Taksali, Sara E, Tamborlane, William V, Petersen, Kitt F, Bonadonna, Riccardo C, Boselli, Linda, Barbetta, Gina, Allen, Karin, Rife, Francis, Savoye, Mary, Dziura, James, Sherwin, Robert, Shulman, Gerald I, Caprio, Sonia

“…Impaired glucose tolerance is common among obese adolescents, but the changes in insulin sensitivity and secretion that lead to this prediabetic state are…”
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Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes by MASON, Graeme F, PETERSEN, Kitt F, LEBON, Vincent, ROTHMAN, Douglas L, SHULMAN, Gerald I

“…Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes Graeme F. Mason 1 2 , Kitt F. Petersen 3 , Vincent Lebon 4 , Douglas L…”
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Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo by Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I.

“…Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis…”
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Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice by Gaspar, Rafael C., Lyu, Kun, Hubbard, Brandon T., Leitner, Brooks P., Luukkonen, Panu K., Hirabara, Sandro M., Sakuma, Ikki, Nasiri, Ali, Zhang, Dongyan, Kahn, Mario, Cline, Gary W., Pauli, José Rodrigo, Perry, Rachel J., Petersen, Kitt F., Shulman, Gerald I.

“…Aims/hypothesis Athletes exhibit increased muscle insulin sensitivity, despite increased intramuscular triacylglycerol content. This phenomenon has been coined…”
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Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus by Petersen, Kitt F, Shulman, Gerald I

“…Insulin resistance is a principal feature of type 2 diabetes and precedes the clinical development of the disease by 10 to 20 years. Insulin resistance is…”
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Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation by Savage, David B, Petersen, Kitt F, Shulman, Gerald I

“…Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type 2 diabetes, and yet, the mechanisms responsible for it remain…”
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Apolipoprotein CIII overexpressing mice are predisposed to diet‐induced hepatic steatosis and hepatic insulin resistance by Lee, Hui‐Young, Birkenfeld, Andreas L., Jornayvaz, Francois R., Jurczak, Michael J., Kanda, Shoichi, Popov, Violeta, Frederick, David W., Zhang, Dongyan, Guigni, Blas, Bharadwaj, Kalyani G., Choi, Cheol Soo, Goldberg, Ira J., Park, Jae‐Hak, Petersen, Kitt F., Samuel, Varman T., Shulman, Gerald I.

“…Nonalcoholic fatty liver disease (NAFLD) and insulin resistance have recently been found to be associated with increased plasma concentrations of…”
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Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo by Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I.

“…In the version of this article originally published, the V PC and V CS flux data shown in Fig. 6e,f were inadvertently duplicated from Fig. 5j,k. The correct…”
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Mechanism by which metformin reduces glucose production in type 2 diabetes by HUNDAL, Ripudaman S, KRSSAK, Martin, SHULMAN, Gerald I, DUFOUR, Sylvie, LAURENT, Didier, LEBON, Vincent, CHANDRAMOULI, Visvanathan, INZUCCHI, Silvio E, SCHUMANN, William C, PETERSEN, Kitt F, LANDAU, Bernard R

“…Mechanism by which metformin reduces glucose production in type 2 diabetes. R S Hundal , M Krssak , S Dufour , D Laurent , V Lebon , V Chandramouli , S E…”
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The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy by Boumezbeur, Fawzi, Petersen, Kitt F, Cline, Gary W, Mason, Graeme F, Behar, Kevin L, Shulman, Gerald I, Rothman, Douglas L

“…To determine whether plasma lactate can be a significant fuel for human brain energy metabolism, infusions of [3-(13)C]lactate and (1)H-(13)C polarization…”
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