Search Results - "Peters, Wilbert H. M"

Towards the human colorectal cancer microbiome by Marchesi, Julian R, Dutilh, Bas E, Hall, Neil, Peters, Wilbert H M, Roelofs, Rian, Boleij, Annemarie, Tjalsma, Harold

“…Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with…”
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Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men by van Wijck, Kim, Lenaerts, Kaatje, van Loon, Luc J C, Peters, Wilbert H M, Buurman, Wim A, Dejong, Cornelis H C

“…Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that…”
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Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial by Pickkers, Peter, Heemskerk, Suzanne, Schouten, Jeroen, Laterre, Pierre-François, Vincent, Jean-Louis, Beishuizen, Albertus, Jorens, Philippe G, Spapen, Herbert, Bulitta, Michael, Peters, Wilbert H M, van der Hoeven, Johannes G

“…To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sepsis-induced acute kidney injury (AKI), a prospective, double-blind,…”
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Over-expression of COX-2 mRNA in colorectal cancer by Roelofs, Hennie M J, Te Morsche, Rene H M, van Heumen, Bjorn W H, Nagengast, Fokko M, Peters, Wilbert H M

“…Cyclooxygenase-2 (COX-2, PTGS2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as…”
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Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer by Ong, Jennie, Salomon, Jody, te Morsche, Rene H M, Roelofs, Hennie M J, Witteman, Ben J M, Dura, Polat, Lacko, Martin, Peters, Wilbert H M

“…Numerous factors influence the development of gastrointestinal (GI) cancer. The insulin-like growth factor (IGF) axis plays a role in embryonic and postnatal…”
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Liver Manipulation Causes Hepatocyte Injury and Precedes Systemic Inflammation in Patients Undergoing Liver Resection by Poll, Marcel C. G., Derikx, Joep P. M., Buurman, Wim A., Peters, Wilbert H. M., Roelofs, Hennie M. J., Wigmore, Stephen J., Dejong, Cornelis HC

“…Background Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass. This can be due to insufficient liver volume and…”
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Influence of Curcumin, Quercetin, and Eicosapentaenoic Acid on the Expression of Phase II Detoxification Enzymes in the Intestinal Cell Lines HT-29, Caco-2, HuTu 80, and LT97 by Odenthal, Julia, van Heumen, Bjorn W. H, Roelofs, Hennie M. J, te Morsche, Rene H. M, Marian, Brigitte, Nagengast, Fokko M, Peters, Wilbert H. M

“…Curcumin, quercetin, and eicosapentaenoic acid (EPA) are 3 natural compounds with the capacity to reduce adenoma burden in patients with familial adenomatous…”
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Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro by Broekman, Mark M. T. J., Roelofs, Hennie M. J., Wong, Dennis R., Kerstholt, Mariska, Leijten, Alex, Hoentjen, Frank, Peters, Wilbert H. M., Wanten, Geert J. A., de Jong, Dirk J.

“…Introduction The use of thiopurines is frequently accompanied by hepatotoxicity. Studies on hepatocyte cultures showed a time- and dose-dependent increase of…”
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Infliximab Exerts No Direct Hepatotoxic Effect on HepG2 Cells In Vitro by de Vries, Hilbert S., de Heij, Tineke, Roelofs, Henie M. J., te Morsche, Rene H. M., Peters, Wilbert H. M., de Jong, Dirk J.

“…Background Infliximab-induced hepatotoxicity is reported in several case studies involving patients with inflammatory bowel disease (IBD) and a direct…”
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Assessment of oxidative stress in chronic pancreatitis patients by Verlaan, Mariette, Roelofs, Hennie M J, van-Schaik, Annie, Wanten, Geert J A, Jansen, Jan B M J, Peters, Wilbert H M, Drenth, Joost P H

“…AIM： To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis （CP） patients in comparison with those in healthy…”
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The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease by de Vries, Hilbert S, te Morsche, Rene H M, van Oijen, Martijn G H, Nagtegaal, Iris D, Peters, Wilbert H M, de Jong, Dirk J

“…Cyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins. COX-2 is mainly induced at sites of inflammation…”
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COX-2 polymorphisms and the risk for head and neck cancer in white patients by Peters, Wilbert H. M., Lacko, Martin, te Morsche, Rene H. M., Voogd, Adri C., Oude Ophuis, Michael B., Manni, Johannes J.

“…Background. Cyclooxygenase‐2 (COX‐2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes such as…”
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Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients by Heemskerk, Suzanne, Masereeuw, Rosalinde, Moesker, Olof, Bouw, Martijn P. W. J. M, van der Hoeven, Johannes G, Peters, Wilbert H. M, Russel, Frans G. M, Pickkers, Peter

“…OBJECTIVE:Alkaline phosphatase (AP) attenuates inflammatory responses by lipopolysaccharide detoxification and may prevent organ damage during sepsis. To…”
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Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity by Tostmann, Alma, Boeree, Martin J, Peters, Wilbert H.M, Roelofs, Hennie M.J, Aarnoutse, Rob E, van der Ven, André J.A.M, Dekhuijzen, P.N. Richard

“…Abstract Antituberculosis drug-induced hepatotoxicity (ATDH) complicates the treatment of 5–10% of patients treated for active tuberculosis (TB). Knowledge…”
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Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis by Friederich, Pieter, Verschuur, Jelle, van Heumen, Bjorn W. H., Roelofs, Hennie M. J., Berkhout, Marloes, Nagtegaal, Iris D., van Oijen, Martijn G. H., van Krieken, Johannes H. J. M., Peters, Wilbert H. M., Nagengast, Fokko M.

“…Background/aim In order to define future chemoprevention strategies for adenomas or carcinomas in the pouch of patients with familial adenomatous polyposis…”
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Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer by Lacko, Martin, Roelofs, Hennie M. J., te Morsche, Rene H. M., Voogd, Adri C., Ophuis, Michael B. Oude, Peters, Wilbert H. M., Manni, Johannes J.

“…Background. UGT1A7 is an enzyme involved in the metabolism of (pre)carcinogens present in tobacco smoke. We investigated whether genetic polymorphisms in…”
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Short-term beneficial effects of methylene blue on kidney damage in septic shock patients by Heemskerk, Suzanne, van Haren, Frank M. P., Foudraine, Norbert A., Peters, Wilbert H. M., van der Hoeven, Johannes G., Russel, Frans G. M., Masereeuw, Rosalinde, Pickkers, Peter

“…Objective We previously demonstrated that upregulation of renal inducible nitric oxide synthase (iNOS) is associated with proximal tubule injury during…”
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Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system by Steiner, Claudia, Peters, Wilbert H.M., Gallagher, Evan P., Magee, Pamela, Rowland, Ian, Pool-Zobel, Beatrice L.

“…Epidemiological studies have shown that ingestion of isoflavone-rich soy products is associated with a reduced risk for the development of breast cancer. In…”
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COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk by Hoff, Juliët H, te Morsche, Rene H M, Roelofs, Hennie M J, van der Logt, Elise M J, Nagengast, Fokko M, Peters, Wilbert H M

“…To determine the possible modulating effect of the COX-2 polymorphisms, -765G-->C and -1195A-->G, on the risk of colorectal cancer (CRC) in a Dutch population…”
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Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid by Van Oijen, Martijn G. H., Huybers, Sylvie, Peters, Wilbert H. M., Drenth, Joost P. H., Laheij, Robert J. F., Verheugt, Freek W. A., Jansen, Jan B. M. J.

“…Background As acetylsalicylic acid is metabolized by UDP‐glucuronosyltransferase 1A6 (UGT1A6) and cytochrome P450 2C9 (CYP2C9), interindividual differences in…”
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