Search Results - "Peters, Shirley J"

Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries by Bhatta, Pallavi, Whale, Kevin D, Sawtell, Amy K, Thompson, Clare L, Rapecki, Stephen E, Cook, David A, Twomey, Breda M, Mennecozzi, Milena, Starkie, Laura E, Barry, Emily M C, Peters, Shirley J, Kamal, Ahmad M, Finney, Helene M

“…Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging. Here we…”
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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation by Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.

“…The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through…”
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Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry by Pacholarz, Kamila J., Peters, Shirley J., Garlish, Rachel A., Henry, Alistair J., Taylor, Richard J., Humphreys, David P., Barran, Perdita E.

“…The aggregation of protein‐based therapeutics such as monoclonal antibodies (mAbs) can affect the efficacy of the treatment and can even induce effects that…”
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Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability by Peters, Shirley J., Smales, C. Mark, Henry, Alistair J., Stephens, Paul E., West, Shauna, Humphreys, David P.

“…The integrity of antibody structure, stability, and biophysical characterization are becoming increasingly important as antibodies receive increasing scrutiny…”
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Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions by Rowley, Tania F., Peters, Shirley J., Aylott, Mike, Griffin, Robert, Davies, Nicola L., Healy, Louise J., Cutler, Rona M., Eddleston, Alison, Pither, Thomas L., Sopp, Joshua M., Zaccheo, Oliver, Fossati, Gianluca, Cain, Katharine, Ventom, Andrew M., Hailu, Hanna, Ward, Eleanor J., Sherington, John, Brennan, Frank R., Fallah-Arani, Farnaz, Humphreys, David P.

“…Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors,…”
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Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries by Bhatta, Pallavi, Whale, Kevin D., Sawtell, Amy K., Thompson, Clare L., Rapecki, Stephen E., Cook, David A., Twomey, Breda M., Mennecozzi, Milena, Starkie, Laura E., Barry, Emily M. C., Peters, Shirley J., Kamal, Ahmad M., Finney, Helene M.

“…Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging. Here we…”
Get full text