Search Results - "Peters, Matthew F"

Label-free whole-cell assays: expanding the scope of GPCR screening by Scott, Clay W, Peters, Matthew F.

“…A new class of instruments offers an unprecedented combination of label-free detection with exquisite sensitivity to live-cell responses. These instruments can…”
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Deconvoluting Kinase Inhibitor Induced Cardiotoxicity by Lamore, Sarah D, Ahlberg, Ernst, Boyer, Scott, Lamb, Michelle L, Hortigon-Vinagre, Maria P, Rodriguez, Victor, Smith, Godfrey L, Sagemark, Johanna, Carlsson, Lars, Bates, Stephanie M, Choy, Allison L, Stålring, Jonna, Scott, Clay W, Peters, Matthew F

“…Many drugs designed to inhibit kinases have their clinical utility limited by cardiotoxicity-related label warnings or prescribing restrictions. While this…”
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Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs by Peters, Matthew F, Knappenberger, Katharine S, Wilkins, Deidre, Sygowski, Linda A, Lazor, Lois Ann, Liu, Jianwei, Scott, Clay W

“…Cellular dielectric spectroscopy (CDS) is an emerging technology capable of detecting a range of whole-cell responses in a label-free manner. A new CDS-based…”
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Cardiovascular Toxicity Induced by Kinase Inhibitors: Mechanisms and Preclinical Approaches by Lamore, Sarah D, Kohnken, Rebecca A, Peters, Matthew F, Kolaja, Kyle L

“…Kinase inhibitors have transformed the treatment of many cancers and are showing the same promise for other indications including inflammatory diseases. This…”
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Human induced pluripotent stem cells and their use in drug discovery for toxicity testing by Scott, Clay W, Peters, Matthew F., Dragan, Yvonne P.

“…Predicting human safety risks of novel xenobiotics remains a major challenge, partly due to the limited availability of human cells to evaluate tissue-specific…”
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Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems by Peters, Matthew F, Choy, Allison L, Pin, Carmen, Leishman, Derek J, Moisan, Annie, Ewart, Lorna, Guzzie-Peck, Peggy J, Sura, Radhakrishna, Keller, Douglas A, Scott, Clay W, Kolaja, Kyle L

“…Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials. High prevalence of DI-GIT has persisted among…”
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An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of cardiac contractility by Scott, Clay W, Zhang, Xiaoyu, Abi-Gerges, Najah, Lamore, Sarah D, Abassi, Yama A, Peters, Matthew F

“…Cardiovascular toxicity, a prominent reason for late-stage failures in drug development, has resulted in a demand for in vitro assays that can predict this…”
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Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs by Belair, David G., Visconti, Richard J., Hong, Miyoun, Marella, Mathieu, Peters, Matthew F., Scott, Clay W., Kolaja, Kyle L.

“…Drug-induced gastrointestinal toxicity (GIT) is a common treatment-emergent adverse event that can negatively impact dosing, thereby limiting efficacy and…”
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Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea by Peters, Matthew F, Landry, Tim, Pin, Carmen, Maratea, Kim, Dick, Cortni, Wagoner, Matthew P, Choy, Allison L, Barthlow, Herb, Snow, Deb, Stevens, Zachary, Armento, Alex, Scott, Clay W, Ayehunie, Seyoum

“…Abstract Drug-induced gastrointestinal toxicities (GITs) rank among the most common clinical side effects. Preclinical efforts to reduce incidence are limited…”
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Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line by Peters, Matthew F., Lamore, Sarah D., Guo, Liang, Scott, Clay W, Kolaja, Kyle L.

“…Cardiovascular (CV) toxicity is a leading cause of drug attrition and withdrawal. Introducing in vitro assays with higher throughput should permit earlier CV…”
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Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity by Peters, Matthew F, Scott, Clay W

“…G-protein-coupled receptors can couple to different signal transduction pathways in different cell types (termed cell-specific signaling) and can activate…”
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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity by Lamore, Sarah D, Kamendi, Harriet W, Scott, Clay W, Dragan, Yvonne P, Peters, Matthew F

“…Cardiovascular (CV) toxicity is a leading contributor to drug attrition. Implementing earlier testing has successfully reduced human Ether-à-go-go-Related…”
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Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications by Peters, Matthew F, Scott, Clay W, Ochalski, Rafal, Dragan, Yvonne P

“…Cardiovascular toxicity is a leading contributor to drug withdrawal and late-stage attrition. Earlier and broader screening is a validated approach to build-in…”
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Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity by Nucifora, Frederick C., Sasaki, Masayuki, Peters, Matthew F., Huang, Hui, Cooper, Jillian K., Yamada, Mitsunori, Takahashi, Hitoshi, Tsuji, Shoji, Troncoso, Juan, Dawson, Valina L., Dawson, Ted M., Ross, Christopher A.

“…Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington's disease (HD) and related disorders, through abnormal…”
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Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity by Peters, Matthew F., Zacco, Anna, Gordon, John, Maciag, Carla M., Litwin, Linda C., Thompson, Carolann, Schroeder, Patricia, Sygowski, Linda A., Piser, Timothy M., Brugel, Todd A.

“…The κ-opioid receptor plays a central role in mediating the response to stressful life events. Inhibiting κ-opioid receptor signaling is proposed as a…”
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Comparing label-free biosensors for pharmacological screening with cell-based functional assays by Peters, Matthew F, Vaillancourt, François, Heroux, Madeleine, Valiquette, Manon, Scott, Clay W

“…The diversity and impact of label-free technologies continues to expand in drug discovery. Two classes of label-free instruments, using either an electrical…”
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Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains by Brenman, Jay E, Chao, Daniel S, Gee, Stephen H, McGee, Aaron W, Craven, Sarah E, Santillano, Daniel R, Wu, Ziqiang, Huang, Fred, Xia, Houhui, Peters, Matthew F, Froehner, Stanley C, Bredt, David S

“…Neuronal nitric oxide synthase (nNOS) is concentrated at synaptic junctions in brain and motor endplates in skeletal muscle. Here, we show that the N-terminus…”
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Preparation of human cDNAs encoding expanded polyglutamine repeats by PETERS, M. F, ROSS, C. A

“…At least eight neurodegenerative diseases result from expansions of polyglutamine tracts encoded by CAG trinucleotide repeats. Although polyglutamine diseases…”
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Differential Association of Syntrophin Pairs with the Dystrophin Complex by Peters, Matthew F., Adams, Marvin E., Froehner, Stanley C.

“…The syntrophins are a multigene family of intracellular dystrophin-associated proteins comprising three isoforms, α1, β1, and β2. Based on their domain…”
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SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2 by Brugel, Todd A., Smith, Reed W., Balestra, Michael, Becker, Christopher, Daniels, Thalia, Koether, Gerard M., Throner, Scott R., Panko, Laura M., Brown, Dean G., Liu, Ruifeng, Gordon, John, Peters, Matthew F.

“…Additional SAR for an extended set of structural modification to key moieties of a novel series of selective kappa opioid receptor antagonists based on a…”
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